A5048916697- Retinoids in leukemia and cellular processes
- Carbon Nanotubes in Composites
- Estrogen and related hormone effects
- Digestive system and related health
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Diamond and Carbon-based Materials Research
- Face and Expression Recognition
- Endoplasmic Reticulum Stress and Disease
- Clinical Nutrition and Gastroenterology
- Cancer, Hypoxia, and Metabolism
- Advanced Clustering Algorithms Research
- Advanced Neural Network Applications
- Handwritten Text Recognition Techniques
- IL-33, ST2, and ILC Pathways
- Complex Network Analysis Techniques
- Metaheuristic Optimization Algorithms Research
- Mechanical and Optical Resonators
- Amino Acid Enzymes and Metabolism
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Ion-surface interactions and analysis
- Ubiquitin and proteasome pathways
- Data Stream Mining Techniques
Washington University in St. Louis
2008-2024
Third Xiangya Hospital
2020-2024
Central South University
2020-2024
Chongqing University
2005-2022
University of Electronic Science and Technology of China
2020-2022
Huzhou University
2021
Xiamen University
2018
University of Georgia
1996
Cellular retinol-binding protein II (CRBP II) is a member of the cellular family, which expressed primarily in small intestine. To investigate physiological role CRBP II, gene encoding was inactivated. The saturable component intestinal retinol uptake impaired <i>CRBP II</i> <sup>−/−</sup> mice. knockout mice, while maintained on vitamin A-enriched diet, have reduced (40%) hepatic A stores but grow and reproduce normally. However, reducing maternal dietary to marginal levels during latter...
Clustering analysis has the very broad applications on data analysis, such as mining, machine learning, and information retrieval. In practice, most of clustering algorithms suffer from effects noises, different densities shapes, cluster overlaps, etc. To solve problems, in this paper, we propose a simple but effective density-based framework (DCF) implement algorithm based DCF. DCF, raw set is partitioned into core points non-core by neighborhood density estimation model, then are clustered...
Retinoid X receptors (RXRs) are nuclear that can activate transcription as homodimers or obligate heterodimeric partners of other receptors. While the crystal structures RXR ligand-binding domains (LBD) have been previously determined, dynamics activation is less well characterized at an atomic level. To probe effect ligand binding on LBD dynamics, we initiated magnetic resonance studies recombinant human RXRα (T223−T462) with and without bound 9-cis-retinoic acid (9cRA). The 1HN, 15N, 13Cα,...
NOD2 single nucleotide polymorphisms have been associated with increased risk of ileal Crohn's disease (CD). This exploratory study was conducted to compare mucosal gene expression in CD patients and without alleles. Ileal samples were prospectively collected from 18 nonsmoking not treated anti-TNF-α biologics 9 control inflammatory bowel undergoing initial resection genotyped for the 3 major alleles (Arg702Trp, Gly908Arg, Leu1007fs). Microarray analysis performed 4 NOD2R (at least 1 allele)...
This paper focuses on traffic sign spotting (TSS which automatically recognizes not only the conventional signs but also information, facility and service signs, lights. TSS is divided into two sequential tasks: detecting candidate regions in an image recognizing regions. It a very challenging task. We make following contributions: 1) we create collection from driverless car. The are shot under natural environment covers large variation illuminance weather conditions. contains common called...
Abstract The effect of retinoid X receptor (RXR) antagonists on the conformational exchange RXR ligand‐binding domain (LBD) remains poorly characterized. To address this question, we used nuclear magnetic resonance spectroscopy to compare chemical shift perturbations induced by and agonists RXRα LBD when partnered with itself as a homodimer heterodimeric partner peroxisome proliferator‐activated γ (PPARγ) LBD. Chemical mapping crystal structure showed that agonist binding abolished...
FMX101 4%, as a topical foam formulation of minocycline, has been approved by US Food and Drug Administration for the treatment moderate-to-severe acne vulgaris (AV).
Effective therapies are limited for patients with parenteral nutrition-dependent short bowel syndrome. We previously showed that intestinal expression of the transcriptional coregulator tetradecanoyl phorbol acetate-induced sequence 7 (tis7) is markedly increased during adaptive response following massive small resection and tis7 plays a role in normal gut lipid metabolism. Here, we further explore functional implications deletion metabolism resection. Intestinal transgenic (tis7(tg)),...
Interactions between the epithelium and surrounding mesenchyme/stroma play an important role in normal gut morphogenesis, epithelial response to injury, carcinogenesis. The tumor microenvironment, composed of stromal cells including myofibroblasts immune cells, regulates growth cancer stem cell niche. Deletion epimorphin (Epim), a syntaxin family member expressed macrophages, results partial protection from colitis inflammation-induced colon mice. We sought determine whether deletion...
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Stem cell therapy is a potential therapeutic approach for disorders characterized by intestinal injury or loss of functional surface area. function and proliferation are mediated the stem niche. Stromal cells such as subepithelial myofibroblasts (ISEMFs) important but poorly studied components To examine role ISEMFs, we have previously generated mice with deletion epimorphin ( Epim), an ISEMF protein member syntaxin family intracellular vesicle docking proteins that regulate secretion....
Recently, Local Binary Pattern (LBP) operator has been applied into face recognition successfully. Center-symmetric is a variation of LBP, which can not only reduce the dimensionality LBP features, but also capture gradient information better than basic LBP. In this paper, an algorithm proposed for based on center-symmetric The main idea using three times extracting three-level features with assumption that gray image encoded by still image. Since different level make contributions to...
The strain-induced resistance changes of both SWNT and MWNT films have been studied. Carbon nanotubes in this study were synthesized by hot filament chemical vapor deposition. Experimental results showed that there is a striking piezoresistive effect carbon nanotube films. relative change was increased with the increasing strain. In same strain, exceed origin may be caused bandgap intertube contact resistance.
Mining feature evolvable streams has gained increasing attention in recent years. However, most existing approaches are designed for stationary data (i.e., without concept drifts) and often work with high time complexity due to the time-consuming optimization procedure. The two deficiencies thus largely limit its applications real-world stream scenarios. In this paper, we consider a more difficult but practical streaming setting: both drifts features. To end, propose general framework mining...
Benign prostatic hyperplasia (BPH) increasingly becomes a common factor affecting the quality of life aging men. Its pathogenesis has not yet been fully elucidated. Ultra-high pressure liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was employed to detect changes serum metabolites in normal mice, benign model mice and BPH with finasteride intervention. The metabolite profiles three groups were analyzed. Partial least squares-discriminant analysis (PLS-DA)...