A5082713628- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- melanin and skin pigmentation
- Syphilis Diagnosis and Treatment
- Skin and Cellular Biology Research
- Dermatological and COVID-19 studies
- Acne and Rosacea Treatments and Effects
- NF-κB Signaling Pathways
- Systemic Sclerosis and Related Diseases
- Lymphatic System and Diseases
- Allergic Rhinitis and Sensitization
- Cancer and Skin Lesions
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- Dermatologic Treatments and Research
- Nail Diseases and Treatments
- IL-33, ST2, and ILC Pathways
- Mast cells and histamine
- Skin Diseases and Diabetes
- T-cell and B-cell Immunology
Qufu Normal University
2025
Second Affiliated Hospital of Zhejiang University
2016-2025
Shandong Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Creative Commons
2020-2023
Zhejiang University
2007-2023
University of South China
2023
Weatherford College
2023
Health First
2022
Barro Colorado Island
2020
Vascular endothelial growth factor (VEGF) plays an important role in normal and pathological angiogenesis. VEGF receptors (VEGFRs, including VEGFR-1, VEGFR-2, VEGFR-3) neuropilins (NRPs, NRP-1 NRP-2) are high-affinity for typically considered to be specific cells. Here we showed expression of VEGFRs NRPs on cultured epidermal keratinocytes at both mRNA protein levels. We further localized these by immunofluorescence (IF) staining the epidermis surgical skin specimens. found positive all...
Abstract Background: Atopic dermatitis (AD) affects approximately 10% of adults worldwide. CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks and interleukin-13 signaling. This trial aimed to evaluate the efficacy safety in Chinese with moderate-to-severe AD. Methods: multicenter, randomized, double-blind, placebo-controlled, phase 2b was conducted 21 medical institutions China from February November 2021. Totally 120 eligible patients were enrolled...
While epidemiological data suggest a connection between atopic dermatitis (AD) and COVID-19, the molecular mechanisms underlying this relationship remain unclear. To investigate whether COVID-19-related CpGs may contribute to AD development association is mediated through regulation of specific genes' expression. We combined Mendelian randomization transcriptome analysis for data-driven explorations. Among 172 -associated with COVID-19 infection, merely 3 them exhibited significant impacts...
Introduction Under the background of COVID-19, people’s mental health problems are concerned by researchers. Network analysis is a new method exploring interactions between issues at symptom level. This study investigates network structure generalized anxiety symptoms among Chinese residents during COVID-19 pandemic from perspective “society-family-personality,” and explores its relationship with Big Five personality traits perceived social support. Methods A multi-stage random sampling...
Co-infection with Novel Duck Orthoreovirus (N-DRV) and Salmonella Typhimurium (S. Typhimurium) poses significant threats to duck health. The disease associated N-DRV is characterized by epizootic outbreaks featuring hepatosplenomegaly, hemorrhage, necrosis. Ducklings infected STM primarily exhibit symptoms such as fibrinous pericarditis, perihepatitis, intestinal hemorrhage. In recent years, China has experienced involving mixed infections of these two pathogens in various regions, leading...
<title>Abstract</title> Psoriasis is a chronic, complex immune-mediated inflammatory disorder with cutaneous and systemic manifestations in which keratinocytes, dendritic cells T have central roles. UBE2L3 may be protective biomarker that regulates the pathogenesis of psoriasis. Here, we identified IL-17A signaling similarity between human psoriatic skin <italic>Ube2l3</italic> conditional knockout mouse epidermis rather than dermis. was regulated by CXCR6<sup>+</sup> Vγ2<sup>+ </sup>γδT...
Abstract Tissue-resident memory T (TRM) cells are a recently defined subtype of non-recirculating with longevity and protective functions in peripheral tissues. As an essential frontline defense against infections, TRM have been reported to robustly patrol the tissue microenvironment malignancies. Accumulating evidence also implicates that relapse chronic inflammatory skin diseases such as psoriasis vitiligo. In light these developments, this review aims synthesize recent findings enhance...
Background: GR1802 is a newly developed, fully humanized monoclonal antibody targeting the interleukin‐4 receptor alpha (IL‐4Rα) subunit, which component common to both IL‐4 and IL‐13 complexes. Objectives: Our objective was assess efficacy of in adult patients presenting with moderate‐to‐severe atopic dermatitis. Methods: In this clinical trial, dermatitis were randomly assigned receive either 300 mg GR1802, 150 or placebo every 2 weeks for 16 weeks. Primary endpoints Eczema Area Severity...
Background: The current management for prurigo nodularis (PN) is challenging. Tofacitinib may emerge as a promising treatment PN. Aim: This study aimed to assess the efficacy and safety of tofacitinib in treating refractory Design methods: A 16‐week prospective observational pilot was conducted patients with moderate‐to‐severe enrolled received oral tofacitinib. primary endpoints included improvement pruritus quality life, measured by investigator’s global assessment (IGA), activity score...
Abstract: Background: Stapokibart has been approved for the treatment of adults with atopic dermatitis (AD) in China.
Abstract Psoriasis is a common chronic inflammatory disease of the skin characterized by epidermal hyperplasia and angiogenesis. Recently, vascular endothelial growth factor receptors (VEGFRs, including VEGFR‐1, VEGFR‐2 VEGFR‐3) were found to be expressed in normal human epidermis associated with proliferation migration keratinocytes. The purpose this study investigate expression VEGFRs on psoriatic keratinocytes roles calcium VEGF regulating VEGFR expression. Skin samples from 17 patients...
Vascular endothelial growth factor (VEGF) promotes angiogenesis and plays important roles in neovascularization development of tissues. VEGF receptors (VEGFRs) are high-affinity for originally considered specific to cells. We have previously shown that keratinocytes from human normal skin express VEGFRs. This poses the question whether these also expressed by epidermal appendages, as appendages lined with epithelial cells.To investigate expression VEGFR-2 compare including hair follicles,...