A5103268614- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Skin Protection and Aging
- Cytokine Signaling Pathways and Interactions
- Mast cells and histamine
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- COVID-19 Clinical Research Studies
- Oral Health Pathology and Treatment
- Dermatologic Treatments and Research
- Antifungal resistance and susceptibility
- Chronic Kidney Disease and Diabetes
- Circadian rhythm and melatonin
- Long-Term Effects of COVID-19
- Renal Diseases and Glomerulopathies
- Urticaria and Related Conditions
- melanin and skin pigmentation
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Acute Kidney Injury Research
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
- Exercise and Physiological Responses
People's Hospital of Shiyan
2018-2024
Hubei University of Medicine
2018-2024
Hubei University
2023
Zhongnan Hospital of Wuhan University
2015
Wuhan University
2015
Background: GR1802 is a newly developed, fully humanized monoclonal antibody targeting the interleukin‐4 receptor alpha (IL‐4Rα) subunit, which component common to both IL‐4 and IL‐13 complexes. Objectives: Our objective was assess efficacy of in adult patients presenting with moderate‐to‐severe atopic dermatitis. Methods: In this clinical trial, dermatitis were randomly assigned receive either 300 mg GR1802, 150 or placebo every 2 weeks for 16 weeks. Primary endpoints Eczema Area Severity...
Dual specificity phosphatase 22 (DUSP22) plays an important role in the regulation of immune and inflammation, but its correlation with clinical features treatment outcome psoriasis patients is still unclear. This study was to investigate longitudinal change DUSP22 time, as well association disease activity response patients.Totally, 120 patients, 50 other skin inflammations controls (DCs), health (HCs) were recruited. Serum samples collected from at baseline, month (M)1, M3, M6 after...
Psoriasis, a chronic and recurrent inflammatory skin disease, current treatments can only alleviate its symptoms. There is still no complete cure. Although increasing research supports the therapeutics to be better, common mechanism of occurrence not fully elucidated. Our study about further explore molecular this disease.
A 73-year-old nephrotic female developed acute renal failure (ARF) with serum creatinine to 586 umol/l after 4 days of therapy hydroxyethyl starch (HES). Renal biopsy demonstrated that the histopathological appearance was mesangioproliferative glomerulonephritis tubulointerstitial changes resembling nephritis. "Pulse" methylprednisolone, hemodialyses and other symptomatic treatment were performed in patient during oliguric phase disease. There no worsening her function, subsequently it...
Abstract Contact urticaria is recognized as the wheal and flare reaction at a site from direct contact with chemical or protein agent. Ongoing studies have proposed that gene silencing may promising future in finding optimal treatment of variety disease; hence, aim study was to investigate effect RNA interference–mediated E‐selectin ( SELE ) on cell adhesion molecule expression cell‐cell vascular endothelial cells (VECs) mouse model immunologic (ICU). Following successful establishment...
Background: Ustekinumab, as a monoclonal antibody against interleukin (IL)-12 and IL-23, gets approved in China since 2019, therefore fewstudies report the application of ustekinumab treating Chinese psoriasis patients real clinical settings until now. Aims: Thus, this study aimed to evaluate treatment efficacy, response–related factors, safety patients. Materials Methods: Totally, 72 moderate-to-severe plaque who underwent were analyzed. Their data recorded. Furthermore, improvement area...