A5066209151- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Nutrition and Physiology
- Livestock Farming and Management
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Animal Genetics and Reproduction
- Silkworms and Sericulture Research
- Bone Metabolism and Diseases
- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Muscle Physiology and Disorders
- Molecular Biology Techniques and Applications
- Parathyroid Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Animal Virus Infections Studies
- Livestock and Poultry Management
- Biochemical Analysis and Sensing Techniques
- Identification and Quantification in Food
- Estrogen and related hormone effects
- Viral Infections and Immunology Research
- Trace Elements in Health
- Bariatric Surgery and Outcomes
- Prenatal Screening and Diagnostics
Chinese Academy of Agricultural Sciences
2014-2025
Institute of Animal Sciences
2015-2024
State Key Laboratory of Animal Nutrition
2018-2023
Ministry of Agriculture and Rural Affairs
2018-2023
Ministère de l'Agriculture et de la Souveraineté alimentaire
2018-2022
Ministry of Agriculture & Farmers Welfare
2018-2022
Northwest A&F University
2022
Chinese Academy of Tropical Agricultural Sciences
2019
Affiliated Zhongshan Hospital of Dalian University
2016
Zunyi Medical University
2015
Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, phenotypes are fine-mapped based on resequencing 1026 ducks from F2 segregating generated by wild × domestic crosses. Interestingly, two key economic traits duck associated with selective sweeps fixed...
Abstract Background The genetic basis of animal domestication remains poorly understood, and systems with substantial phenotypic differences between wild domestic populations are useful for elucidating the adaptation to new environments as well rapid change. Here, we sequenced whole genome 78 individual ducks, from two seven domesticated populations, an average sequencing depth 6.42X per individual. Results Our population demographic analyses indicate a complex history domestication, early...
Abstract Genomic selection (GS) has great potential to increase genetic gain in poultry breeding. However, the performance of genomic prediction duck growth and breast morphological (BM) traits remains largely unknown. The objective this study was evaluate benefits for BM using methods such as GBLUP, single‐step Bayesian models, different marker densities. This collected phenotypic data 14 a crossbreed population 1893 Pekin × mallard, which included 941 genotyped ducks. estimation parameters...
Co-infection with Novel Duck Orthoreovirus (N-DRV) and Salmonella Typhimurium (S. Typhimurium) poses significant threats to duck health. The disease associated N-DRV is characterized by epizootic outbreaks featuring hepatosplenomegaly, hemorrhage, necrosis. Ducklings infected STM primarily exhibit symptoms such as fibrinous pericarditis, perihepatitis, intestinal hemorrhage. In recent years, China has experienced involving mixed infections of these two pathogens in various regions, leading...
Abstract Background Expression quantitative trait loci (eQTL) studies aim to understand the influence of genetic variants on gene expression. The colocalization eQTL mapping and GWAS strategy could help identify essential candidate genes causal DNA vital complex traits in human many farm animals. However, has not been conducted ducks. It is desirable know whether eQTLs within signals contributed duck economic traits. Results In this study, we an analysis using publicly available RNA...
Objective The feed intake (FI) and efficiency are economically important traits in ducks. To obtain insight into this trait, we designed an experiment based on the residual (RFI) conversion ratio (FCR) of a random population Pekin duck. Methods Two thousand twenty pedigreed ducks were established from 90 males mated to 450 females two hatches. Traits analyzed study body weight at 42th day (BW42), 15 42 days average daily gain (ADG), FI, FCR, RFI assess their genetic inter-relationships....
The purpose of this study was to evaluate single nucleotide polymorphism (SNP) variants the estrogen receptor 1 gene (ESR1) at rs2234693 and rs9340799, as well investigate relationship between ESR polymorphisms postmenopausal osteoporosis (OP) spine in Chinese women.We recruited 198 women with OP 276 healthy May 2012 September 2015 Zhongshan Hospital.Dual energy x-ray absorptiometry used measure bone mineral density (BMD) lumbar vertebrae all subjects.In addition, PCR-restriction fragment...
Abstract The thickness of the perimysium has an essential effect on tenderness meat. However, genetic basis underlying perimysial not been determined. objective this study was to explore quantitative trait loci (QTL) that influence in F 2 segregating population generated by Mallard × Pekin duck using genome‐wide association (GWAS) method. Two QTL identified chromosomes 27 and 13 displayed significant associations with traits at level. strongest located chromosome 27, region had contained a...
Abstract Background Carcass traits are crucial for broiler ducks, but carcass can only be measured postmortem. Genomic selection (GS) is an effective approach in animal breeding to improve and reduce costs. However, the performance of genomic prediction duck remains largely unknown. Results In this study, we estimated genetic parameters, performed GS using different models marker densities, compared estimation between conventional BLUP on 35 F 2 population ducks. Most cut weight intestine...
Lean-type Pekin duck is a commercial breed that has been obtained through long-term selection. Investigation of the differentially expressed genes in breast muscle and skin fat at different developmental stages will contribute to comprehensive understanding potential mechanisms underlying lean-type phenotype. In present study, RNA-seq was performed on 2-, 4- 6-weeks age. More than 89% annotated were covered by our dataset. Thousands genes, including many important involved regulation...
Musculoskeletal embryonic nuclear protein 1 (MUSTN1) gene is involved in myogenic fusion and differentiation rats.We previously showed the differential expression of MUSTN1 week (W) 2 W6 breast muscles Pekin ducks.In this study, we further investigated its molecular characteristics profiles different tissues at W7 leg W1, W3, W5, W7, W9.The relationship between muscle development ©FUNPEC-RP www.funpecrp.com.
As a major economic trait in poultry, egg production efficiency attracts widespread interest breeding and production. However, limited information is available about the underlying genetic architecture of traits ducks. In this paper, we analyzed six production-related 352 F2 ducks derived from reciprocal crosses between mallard Pekin ducks.Feed conversation ratio (FCR) was positively correlated with feed intake but negatively egg-related traits, including weight production, both...
Abstract Background Short-term, intense artificial selection drives fast phenotypic changes in domestic animals and leaves imprints on their genomes. However, the genetic basis of this response is poorly understood. To better address this, we employed Pekin duck Z2 pure line, which breast muscle weight was increased nearly 3-fold after 10 generations breeding. We denovo assembled a high-quality reference genome female line (GCA_003850225.1) identified 8.60 million variants 119 individuals...
Abstract Background Phosphorus is essential for bone mineralization in broilers, however, the underlying mechanisms remain unclear. We aimed to investigate whether phosphorus retention and development might be regulated by related hormones local bone-derived regulators broilers. Methods Broilers were fed diets containing different levels of non-phytate (NPP) 0.15%, 0.25%, 0.35%, 0.45% 0.55% or 0.22%, 0.29%, 0.36% 0.43% from 1 21 22 42 days age. Serum tibia samples collected determinations...
As a critical developmental stage in vertebrates, the vertebral column formation process is under strict control; however, we observed variations number of cervical vertebrae duck populations our previous study. Here, further explored two populations: 421 Pekin × mallard F2 ducks and 850 ducks. Using resequencing data 125 with different numbers 352 thoracic vertebrae, detected whole-genome copy (CNVs) implemented genome-wide association study (GWAS) to identify genetic variants related...
This study was conducted to estimate the genetic parameters and breeding values of breast meat related traits Pekin ducks. Selection response also determined by using ultrasound muscle thickness (BMT) measurements in combination with bosom breadth (BB) keel length (KL) values.The analyzed were weight (BMW), body (BW), percentage (BMP) three (BB, KL, BMT). These derived from studying 15,781 ducks selected 10 generations based on weight. Genetic value estimated for analysis process.Estimated...
Lean-type Pekin duck is a breed gained through long-term selection and great effort has been exerted to understand the mechanisms underlying increased muscle yields. However, genes involved in embryonic breast development have not explored date. In this study, we investigated gene expression profiles Duck at hatched day 13 (E13), E19, E27 using RNA-seq. total, produced 519,312,178 raw reads resulting 497,348,158 high-quality after filtering. The mapping, distribution of along annotated...
The bone morphogenetic protein (BMP) and mitogen-activated kinase (MAPK) signaling pathways play an important role in regulation of formation development, however, it remains unclear that the effect dietary different levels non-phytate phosphorus (NPP) on these their correlations with (P) retention development broilers. Therefore, this experiment was conducted to investigate P supplementation BMP MAPK A total 800 one-day-old Arbor Acres male broilers were randomly allotted 1 5 treatments 8...
Summary Egg internal quality traits are important related to egg production in poultry industry. To better understand the genetic architecture of ducks, we performed parameters estimates and a genome‐wide association study (GWAS). The phenotypic values weight, yolk color, albumin height (AH), Haugh unit (HU) were collected individually from 352 F 2 laying ducks produced by reciprocal crosses between mallards Pekin their genotypes assayed whole genome re‐sequencing. results showed that AH HU...
The objective of this study was to investigate the mRNA expression hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM).Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into GBS, sham operation diet restriction (SO), and alone (control) groups (N = per group).Liver specimens from all obtained during 8 weeks operation.Blood lipid levels measured before operation.Fasting blood glucose (FBG),...
Ovulation is a complicated physiological process that regulated by multitude of different pathways. In comparison to mammalian studies, there are few reports ovulation in Muscovy ducks, and the molecular mechanism ovarian development remained unclear. order identify candidate genes metabolites related duck follicular ovulation, study combined Oxford Nanopore Technologies (ONT) full-length transcriptome metabolomics analyze differences gene expression metabolite accumulation ovaries between...
Short tandem repeats (STRs) are usually associated with genetic diseases and gene regulatory functions, also important markers for analysis of evolutionary, diversity forensic. However, the majority STRs in duck genome, their population properties functional impacts remain poorly defined. Recent advent next generation sequencing (NGS) has offered an opportunity profiling large numbers polymorphic STRs. Here, we reported a population-scale STR variation using genome resequencing mallard Pekin...