A5020757248- Neurobiology and Insect Physiology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Cancer-related gene regulation
- Olfactory and Sensory Function Studies
- Physiological and biochemical adaptations
- RNA modifications and cancer
- Circular RNAs in diseases
- Animal Vocal Communication and Behavior
- Psoriasis: Treatment and Pathogenesis
- Retinoids in leukemia and cellular processes
- Antimicrobial Peptides and Activities
- Amphibian and Reptile Biology
- Insect Resistance and Genetics
- HVDC Systems and Fault Protection
- Plant and animal studies
- Receptor Mechanisms and Signaling
- Ultrasound and Hyperthermia Applications
- Radiation Therapy and Dosimetry
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
Second Affiliated Hospital of Zhejiang University
2025
China Medical University
2020-2024
First Hospital of China Medical University
2020-2024
Chinese Institute for Brain Research
2023-2024
Peking University
2022-2024
Institute of Biophysics
2024
Chinese Academy of Sciences
2024
China Agricultural University
2016-2023
McGovern Institute for Brain Research
2022
King University
2022
Abstract Background N 6‐methyladenosine (m6A) modification may participate in the regulation of occurrence and development tumors. However, m6A level potential regulatory mechanism gastric cancer (GC) remain uncertain. Methods RNA quantification assay was conducted to detect GC tissues cell lines. Methyltransferase‐like 14 (METTL14) expression explored by bioinformatics immunohistochemistry. Then, function METTL14 cells examined CCK‐8, colony formation assay, wound healing Transwell assay....
<title>Abstract</title> Psoriasis is a chronic, complex immune-mediated inflammatory disorder with cutaneous and systemic manifestations in which keratinocytes, dendritic cells T have central roles. UBE2L3 may be protective biomarker that regulates the pathogenesis of psoriasis. Here, we identified IL-17A signaling similarity between human psoriatic skin <italic>Ube2l3</italic> conditional knockout mouse epidermis rather than dermis. was regulated by CXCR6<sup>+</sup> Vγ2<sup>+ </sup>γδT...
Introduction Gastric cancer, one of the most common cancers digestive tract, has high incidence and mortality rates. Until recently, surgery been effective method treatment for gastric cancer. Surgery, however, inevitably results in dysfunction autonomic nervous system, entry tumor cells into bloodstream, immunosuppression during perioperative period, all which increase risk complications patients with Opioid receptors play an important role proliferation secretion cytotoxic factors by...
Abstract Background Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims explore the effect microRNA-93-5p (miR-93-5p) on epithelial-mesenchymal transition (EMT) GC, via AHNAK Wnt signaling pathway. Methods Microarray-based gene expression analysis was performed identify GC-related differentially expressed miRNAs genes. Then miR-93-5p examined tissues cell lines. The...
Serotonin (5-hydroxytryptamine; 5-HT) and GABA (γ-aminobutyric acid) are involved in the regulation of behaviors central nervous system. However, it remains unclear whether they modulate olfaction peripheral system, how olfaction.One 5-HT receptor sequence (Lmig5-HT2) one (LmigGABAb) were identified locust antennae by transcriptome analysis polymerase chain reaction experiments. In situ hybridization localized Lmig5-HT2 to accessory cells, while LmigGABAb was olfactory neurons (ORNs)...
Insects have evolved sophisticated olfactory reception systems to sense exogenous chemical signals. Odorant receptors (ORs) on the membrane of chemosensory neurons are believed be key molecules in sensing cues. ORs different species insects diverse and should tune a its own specific semiochemicals relevant their survival. The orthopteran insect, locust (Locusta migratoria), is model hemimetabolous insect. There very limited knowledge functions although many OR genes been identified genomic...
The present study aims to explore the function of human bone marrow mesenchymal stem cell (BMSC)-derived exosomal micro ribonucleic acid (miR)-338-3p in hepatocellular carcinoma (HCC) and further investigate its effect on HCC functions. Firstly, BMSCs were co-cultured with cells, BMSC-derived exosomes identified. Next, Transwell assay methyl thiazolyl tetrazolium (MTT) experiments carried out detect effects miR-338-3p E26 transformation specific-1 (ETS1) viability, invasion, migration,...
Octopamine (OA), analogous to norepinephrine in vertebrates, is an essential monoamine neurotransmitter invertebrates that plays a significant role various biological functions, including olfactory associative learning. However, the spatial and temporal dynamics of OA
Insect defensins are effector components of the innate defense system. During infection, these peptides may play a role in control pathogens by providing protective antimicrobial barriers between epithelial cells and hemocoel. The cDNAs encoding four migratory locust, Locusta migratoria, designated LmDEF 1, 3-5, were identified for first time transcriptome-targeted analysis. Three members this CSαβ defensin family, 3, 5, detected locust tissues. pro regions their sequences have little-shared...
We aimed to reveal if low dose X-rays would induce harmful or beneficial effect dual response on biological cells and whether there are conditions the radiation can enhance gene transfer efficiency promote cell growth but without damage cells.A systematic study was performed effects of Kilo-V Mega-V morphology, viability, membrane permeability, DNA damage, transfection 293 T CHO cells.The very doses from 0.01 0.04 Gray in principle didn't any significant change growth, cause damage. The...
Esophageal cancer (EC) is one of the most common aggressive malignant diseases worldwide. miR-28-5p plays important regulatory roles in many cancers including human EC. However, molecular mechanism and potential role EC remain uncertain. In this study, qRT-PCR western blot analysis revealed that expression was up-regulated metastasis suppressor-1 (MTSS1) down-regulated tissues relative to matched para-cancer tissues. Cell counting kit-8 (CCK-8) assay demonstrated mimics increased cell...
Abstract Temporal coincidence between the conditioned stimulus (CS) and unconditioned (US) is essential for associative learning across species. Despite its ubiquitous presence, mechanism that may regulate this time window duration remains unclear yet. Using olfactory in Drosophila as a model, we find suppressing or promoting serotonin (5-HT) signal could respectively shorten prolong of odor-shock synaptic plasticity mushroom body (MB) Kenyon cells (KCs). Capitalizing on G PC R - ctivation b...
Directional hearing is crucial for animals depending on acoustic signals to locate a mate. We focused crickets explore the reliability of directional information forwarded brain by ascending auditory interneuron AN1, which phonotactic behavior. presented calling song from -45° +45° in steps 3° and compared steering females walking trackball with responses AN1. Forty percent showed good behavior changed their direction when speaker passed body's longitudinal axis. The bilateral latency...
ABSTRACT Octopamine (OA), analogous to norepinephrine in vertebrates, is an essential monoamine neurotransmitter invertebrates that plays a significant role various biological functions, including olfactory associative learning. However, the spatial and temporal dynamics of OA vivo remain poorly understood due limitations associated with currently available methods used detect it. To overcome these limitations, we developed genetically encoded G PC R ctivation- b ased (GRAB) sensor called...