A5042177314- Alzheimer's disease research and treatments
- Effects and risks of endocrine disrupting chemicals
- Aluminum toxicity and tolerance in plants and animals
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Inflammatory Bowel Disease
- Cancer Cells and Metastasis
- Effects of Radiation Exposure
- Sulfur Compounds in Biology
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Fluoride Effects and Removal
China Medical University
2016-2025
Galapagos (France)
2020-2021
Hainan Medical University
2018
State Council of the People's Republic of China
2018
Harbin Medical University
2015-2016
Hubei University of Arts and Science
2015
Xiangyang Central Hospital
2015
Third Affiliated Hospital of Harbin Medical University
2015
Leiden University Medical Center
2013
Radboud University Nijmegen
2008
Abstract Breast cancer is the worldwide leading cause of mortality in women. The majority deaths from breast arise metastasis local tumors. Cancer cells support their rapid proliferation by diverting metabolites into anabolic pathways, but during metastasis, proliferative program invasive suspended for a migratory phenotype. In this study, we demonstrated that both mature forms miRNA-485, miR-485-3p and miR-485-5p were involved regulating mitochondrial respiration, cell migration invasion...
Phosphoglycerate kinase-1 (PGK1) has been recently documented in various malignancies; however, the molecular mechanisms of variable PGK1 expression and its clinical significance terms survival status remain unclear. Real-time quantitative PCR (real-time qPCR) western blotting were used to verify 46 fresh breast cancer tissues matched normal tissues. A tissue microarray (TMA) comprising 401 123 was investigated by immunohistochemistry for expression. Then, correlation between...
Abstract Background N 6‐methyladenosine (m6A) modification may participate in the regulation of occurrence and development tumors. However, m6A level potential regulatory mechanism gastric cancer (GC) remain uncertain. Methods RNA quantification assay was conducted to detect GC tissues cell lines. Methyltransferase‐like 14 (METTL14) expression explored by bioinformatics immunohistochemistry. Then, function METTL14 cells examined CCK‐8, colony formation assay, wound healing Transwell assay....
Bisphenol A (BPA) and di-(2-ethylhcxyl) phthalate (DEHP) are exist widespread in the environment produce adverse effect to human as environmental disruptors (EDCs). Epidemiological studies have found that exposure of DEHP BPA could increase susceptibility thyroid diseases including cancer benign nodules. Due existence multiple pollutants our daily life, mixed toxic effects their interrelationships may distinguish from a single chemical, so it is great significance explore co-exposure....
Breast cancer (BrCa) as one of the major malignancies threatening women's health worldwide occurs due to genetic and environmental interactions. Epidemiological studies have suggested that exposure endocrine disrupting chemicals (EDCs) can elevate risk breast cancer. Di-(2-ethylhexyl)-phthalate (DEHP) bisphenol A (BPA) are known two typical EDCs. Although several implied there appear adverse effects BPA or DEHP alone on development, no study date has demonstrated exact toxic effect combined...
The prevalence of lung cancer in women currently merits our attentions. However, cigarette exposure alone does not tell the whole story that is more prevalent among non-smoking women. Since female closely linked to estrogen levels, many endocrine disrupting chemicals (EDCs), as substances similar estrogen, affect hormone levels and become a potential risk cancer. Additionally, combined toxicity EDCs daily environment has only been discussed on limited scale. Consequently, this study explored...
Activator protein-1 (AP-1) represents a transcription factor family that has garnered growing attention for its extensive involvement in tumor biology. However, the roles of AP-1 evolution lung cancer remain poorly characterized. FBJ Murine Osteosarcoma Viral Oncogene Homolog B (FOSB), classic member, was previously reported to play bewilderingly two-polarized non-small cell (NSCLC) as an enigmatic double-edged sword, which reasons and significance warrant further elucidation.
Epidemiological investigations have indicated that aluminum (Al), as an important environmental neurotoxicant, could cause damage to the cognitive function which was closely related with neurodegenerative diseases. Long-term potentiation (LTP) is one form of synaptic plasticity in association function. Previous studies demonstrated Al impaired early phase long-term (E-LTP) vivo and vitro. However, Al-induced late (L-LTP) has poorly been studied. The present study designed observe effects...
Lanthanum (La) can cause central nervous system damage in rats and lead to learning memory impairment, but the relevant mechanisms have not been fully elucidated.
Abstract Lanthanum exerts adverse effects on the central nervous system. However, mechanism underlying these has not been clarified. It is known that oxidative stress plays an important role in neurological injuries induced by harmful factors. Nuclear factor erythroid 2‐related (Nrf2) very response to tissues and cells. The purpose of this study was explore effect lanthanum chloride (LaCl 3 ) spatial learning memory rats determine whether Nrf2/antioxidant element pathway acts hippocampus....
Lanthanum (La) is a kind of rare earth element (REE) widely found in nature. La has neurotoxicity and can impair learning memory, but the underlying mechanism still not completely clear. The mitochondrial calcium uniporter (MCU) complex cause uptake cytoplasmic ([Ca2+]c) into mitochondria thereby resist [Ca2+]c overload. However, abnormal increase matrix ([Ca2+]m) also disturb fission-fusion balance, then induce excessive mitophagy, disrupt quality control (MQC). It unclear whether interfere...
Epidemiological investigations have shown that aluminium (Al) is an important neurotoxicant which can be absorbed by organisms via various routes. Previous studies confirmed exposure to Al could cause neurodegenerative diseases, decline CREB phosphorylation and then down-regulate the transcription protein expression of its target genes including BDNF. However, recent revealed activation alone was far from enough activate long-term memory (LTM)-related genes; there might other regulatory...