A5036829953- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Pancreatitis Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- NF-κB Signaling Pathways
- Cancer Mechanisms and Therapy
- Helicobacter pylori-related gastroenterology studies
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Ginkgo biloba and Cashew Applications
Harbin Medical University
2016-2025
Third Affiliated Hospital of Harbin Medical University
2013-2025
Heilongjiang Academy of Sciences
2021-2022
Chinese Academy of Sciences
2012
Institute of Biophysics
2012
Abstract Breast cancer is the worldwide leading cause of mortality in women. The majority deaths from breast arise metastasis local tumors. Cancer cells support their rapid proliferation by diverting metabolites into anabolic pathways, but during metastasis, proliferative program invasive suspended for a migratory phenotype. In this study, we demonstrated that both mature forms miRNA-485, miR-485-3p and miR-485-5p were involved regulating mitochondrial respiration, cell migration invasion...
Epithelial to mesenchymal transition (EMT) promotes cellular motility, invasiveness and metastasis during embryonic development tumorigenesis. Transforming growth factor-β (TGF-β) signaling pathway is a key regulator of EMT. A lot evidences suggest that this process Smad3-dependent. Herein we showed exposure aspc-1 panc-1 pancreatic cancer cells TGF-β1 resulted in characteristic morphological alterations EMT, enhancement cell motility gemcitabine (Gem) resistance along with an up-regulation...
Systemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine compare prognostic value neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), fibrinogen-to-albumin (FAR) in resectable PC locally advanced or metastatic PC.Three hundred fifty-three patients with 807 advan-ced were recruited this study. These classified into training...
Gastric cancer (GC) remains a leading cause of cancer-related mortality in the United States and China, there is an urgent need to discover novel non-invasive biomarkers for early diagnosis GC improve prognosis patients. Exosomal miRNAs are considered promising diagnosis. Using next-generation sequencing (NGS), bioinformatics further validation, we identified evaluated exosomal serum as diagnostic markers GC. NGS revealed that average mappable reads RNA libraries were about 6.5 million per...
Abstract Pancreatic cancer (PC) is one of the top two most fatal cancers, with poorest survival rate among all human malignancies. Increasing evidence suggests involvement long noncoding RNAs (lncRNAs) in initiation and progression various cancers. Herein, we investigated role lncRNA LINC01559 PC. Several online databases indicated that was at a low expression normal pancreatic tissues but obviously upregulated PAAD tissues. Further, our results showed stimulated PC cell lines relative to...
There is a lack of useful biomarkers for predicting the efficacy anti–programmed death-1 (PD-1) therapy advanced gastric and colorectal cancer. To address this issue, in study we investigated correlation between inflammatory marker expression survival patients with Data 111 cancer treated anti–PD-1 regimens were retrospectively analyzed. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), clinical characteristics each patient selected as main...
Homeobox B9 (HOXB9) is involved in the occurrence and development of malignant tumors. However, functions underlying molecular mechanisms HOXB9 pancreatic cancer have yet to be identified. In this study, we find that both mRNA protein levels are down-regulated tissues cell lines. Kaplan-Meier survival plots 150 cases show higher expression patients associated with rates. We also over-expression inhibits proliferation lines nude mouse xenograft as well PDX models. Applying cycle PCR array...
Abstract Forkhead box protein M1 (FOXM1) was identified as an oncogenic transcription factor and master regulator of tumor progression metastasis. FOXM1 expression often correlates with poor prognosis chemotherapy resistance. In the present study, we investigated association chemoresistance in pancreatic cancer. Elevated levels were associated gemcitabine patients resistance cell line models cancer, increased, which induced vitro. cancer cells treated gemcitabine, affected nuclear κB (NF-κB)...
A common event upon receptor–ligand engagement is the formation of receptor clusters on cell surface, in which signaling molecules are specifically recruited or excluded to form hubs regulate cellular events. These often transient and can be disassembled terminate signaling. Despite general relevance dynamic clustering signaling, regulatory mechanism underlying dynamics still poorly understood. As a major antigen immune system, T receptors (TCR) spatiotemporally mediate robust yet temporal...
Triple-negative breast cancer (TNBC) is prone to metastasis and has a poor prognosis, with lower survival rates than other subtypes. MicroRNAs have recently emerged as powerful regulators of processes become promising target in therapy.Expression miR-128 was examined invasive ductal cancer, its relationship clinicopathological features analysed. A series vitro vivo experiments were performed investigate the function mechanism development cancer.A cohort 110 women TNBC 117 non-TNBC included...
Gemcitabine resistance will occur by time after the initial response in pancreatic cancer. Ginkgolide B (GB), a major terpene lactone component of Ginkgo biloba leaves, is highly selective and competitive inhibitor for platelet-activating factor (PAF) receptor. In present study, we evaluated effect GB on gemcitabine sensitivity cancer cell lines vitro vivo. Cell viability assay, flow cytometry, dual luciferase reporter assay tumor xenograft model were used to evaluate proliferation,...
To assess the efficacy and safety of lenvatinib/bevacizumab combined with programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors gemcitabine/oxaliplatin (GEMOX) as first-line treatments in patients advanced biliary tract cancer (BTC). Patients BTC who received PD-1/PD-L1 plus chemotherapy were retrospectively screened. The primary endpoints overall survival (OS) progression-free (PFS), whereas secondary objective response rate (ORR), disease control (DCR), safety. Prognostic...
Tumour necrosis factor alpha-induced protein 8 (TNFAIP8) is implicated in the progression of several human malignancies, but its role gastric adenocarcinoma unknown. TNFAIP8 expression and correlation with clinical significance are evaluated this study.The was determined primary tissues using immunohistochemistry (IHC) Western blotting analysis. higher tissues. Elevated associated significantly depth invasion (P = 0.024), lymph node metastasis 0.038) Lauren classification 0.048). Patients...
Purpose: Comparing the efficacy and safety of programmed cell death protein-1 (PD-1) inhibitors combined with tyrosine kinase (TKIs) or without hepatic artery infusion chemotherapy (HAIC) in HBV-related advanced HCC exploring prognostic predictors regimen. Patients Methods: A total 194 patients diagnosed between 2020 2022 were included study, including 99 HAIC PD-1 plus TKIs (HPT group) 95 (PT group). The was evaluated according to tumor response rate survival, adverse events. Results: HPT...
To analyze the effectiveness of combining immune checkpoint inhibitors (ICIs) with first-line therapy in patients advanced biliary tract cancer (BTC) and explore biomarkers affecting prognosis immunotherapy, to construct a nomogram for prediction survival.A retrospective study was conducted include total 209 BTC treated first line from 2018 2022, divided into combination group (n = 129) chemotherapy-only 80) according whether ICIs were applied combination. Univariate multifactorial COX...
The present study aimed to compare the outcome of percutaneous cryosurgery (PC) with surgical resection (SR) in treatment solitary, small hepatocellular carcinoma (HCC), by performing a retrospective cohort on 82 patients solitary HCCs who had received either PC (24 patients) or SR (58 patients). All underwent pretreatment blood chemistry tests and an imaging evaluation were regularly followed up radiological following at Third Affiliated Hospital Harbin Medical University, Harbin,...
Signal transducers and activators of transcription 5 (STAT5) has been shown to be involved in a variety cellular processes, including survival, proliferation, invasion, angiogenesis immune evasion is frequently overexpressed human solid tumors blood malignancies. The aim this study was investigate the role STAT5a colorectal cancer (CRC) progression. We inhibited expression using lentivirus-mediated artificial microRNA (miRNA) interference vitro investigated viability CRC cells by CCK-8...
Systemic inflammation is important in the development of extrahepatic cholangiocarcinoma (ECC). The aim this study was to compare prognostic power preoperative peripheral blood inflammatory markers and novel FLR-N score patients with resectable ECC. A total 140 ECC healthy controls (HCs) were recruited for study. Mann-Whitney U test used evaluate differences between groups. Kaplan-Meier Cox regression analyses fibrinogen, albumin, prealbumin, bilirubin, neutrophils, lymphocytes, monocytes,...
To investigate the efficacy and safety differences between cisplatin + paclitaxel (TP) fluorouracil (PF) regimens in combination with or without immune checkpoint inhibitors (ICIs) advanced esophageal squamous cell carcinoma (ESCC) first-line treatment prognostic factors.We selected medical records of patients late stage ESCC admitted to hospital 2019 2021. Based on regimen, control groups were divided into chemotherapy plus ICIs (n = 243) non-ICIs 171), 119 (49%) TP group, 124 (51%) PF 83...
Constitutive photomorphogenesis 9 (COP9) signalosome 6 (CSN6) plays an essential role in tumor development. The present study aims to demonstrate that CSN6 is important biomarker and has prognostic value for patients with pancreatic ductal adenocarcinoma (PDAC). We analyzed expression levels PDAC adjacent non-cancerous tissues using immunohistochemistry (IHC) quantitative real-time PCR (qPCR) analysis. found was highly expressed tissues, contrasting tissues. Interestingly, positively...