A5077661600- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Kruppel-like factors research
- Glutathione Transferases and Polymorphisms
- Cancer Mechanisms and Therapy
- Fibroblast Growth Factor Research
- Thyroid and Parathyroid Surgery
- Flavonoids in Medical Research
- Pituitary Gland Disorders and Treatments
- PARP inhibition in cancer therapy
- Computational Drug Discovery Methods
- Pancreatic and Hepatic Oncology Research
- Nanoparticle-Based Drug Delivery
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Head and Neck Anomalies
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
Chinese Academy of Sciences
2023-2024
University of Chinese Academy of Sciences
2023-2024
Institute of Biophysics
2023-2024
The First Hospital of Changsha
2024
North China University of Science and Technology
2023
North China University of Science and Technology Affiliated Hospital
2023
University of Wisconsin–Madison
2004-2014
Northwest A&F University
2011
Beijing Tongren Hospital
2005
A common event upon receptor–ligand engagement is the formation of receptor clusters on cell surface, in which signaling molecules are specifically recruited or excluded to form hubs regulate cellular events. These often transient and can be disassembled terminate signaling. Despite general relevance dynamic clustering signaling, regulatory mechanism underlying dynamics still poorly understood. As a major antigen immune system, T receptors (TCR) spatiotemporally mediate robust yet temporal...
T cell receptor (TCR) plays a fundamental role in adaptive immunity, and TCR-T therapy holds great promise for treating solid tumors other diseases. However, there is noticeable absence of chemical tools tuning TCR activity. In our study, we screened natural sterols their regulatory effects on function identified 7-alpha-hydroxycholesterol (7a-HC) as potent inhibitor signaling. Mechanistically, 7a-HC promoted membrane binding CD3ε cytoplasmic domain, crucial signaling component the TCR-CD3...
The role of arbuscular mycorrhizal fungi (AMF) in assisting the growth different fruit tree species is well-established, yet impact loquat cultivation under long-term human management on rhizosphere soil characteristics and AMF community structure remains unresolved. To address this knowledge gap, we collected roots samples from 20-year-old a germplasm resources nursery with consistent water nutrient conditions including one wild (YS), three pure (GXQH, MHH, DWX), four hybrid (ZJ90, JT, JTH,...
Summary The origins of the domestic water buffalo remain contentious. To better understand Chinese buffalo, we sequenced complete mitochondrial cytochrome b ( MT‐CYB ) gene from 270 individuals representing 13 swamp populations. We found genetic evidence introgression river into herds. Swamp haplotypes can be divided two highly divergent lineages (A and B), suggesting that native have maternal origins. A→G transition in stop codon resulted being terminated by one codons: AGA or AGG. is...
Abstract The immune checkpoint molecule, programmed cell death 1 (PD-1), plays a pivotal role in regulating T-cell function. Upon binding to its ligands, PD-L1 or PD-L2, PD-1 suppresses receptor signaling, thereby preventing activation, making it critical target cancer immunotherapy. Although extensively studied, the molecular mechanism of PD-1’s inhibitory function is still not fully understood, especially at atomic level. Using biomembrane force probe (BFP), we discovered that interactions...