A5102898523- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Inhalation and Respiratory Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- interferon and immune responses
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
Shanghai Xuhui Central Hospital
2024
Institute of Biophysics
2023-2024
Chinese Academy of Sciences
2023-2024
A common event upon receptor–ligand engagement is the formation of receptor clusters on cell surface, in which signaling molecules are specifically recruited or excluded to form hubs regulate cellular events. These often transient and can be disassembled terminate signaling. Despite general relevance dynamic clustering signaling, regulatory mechanism underlying dynamics still poorly understood. As a major antigen immune system, T receptors (TCR) spatiotemporally mediate robust yet temporal...
Abstract The immune checkpoint molecule, programmed cell death 1 (PD-1), plays a pivotal role in regulating T-cell function. Upon binding to its ligands, PD-L1 or PD-L2, PD-1 suppresses receptor signaling, thereby preventing activation, making it critical target cancer immunotherapy. Although extensively studied, the molecular mechanism of PD-1’s inhibitory function is still not fully understood, especially at atomic level. Using biomembrane force probe (BFP), we discovered that interactions...