A5071837187- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Histone Deacetylase Inhibitors Research
- Assisted Reproductive Technology and Twin Pregnancy
- Developmental Biology and Gene Regulation
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Congenital Heart Disease Studies
- Iron Metabolism and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gestational Diabetes Research and Management
- Hedgehog Signaling Pathway Studies
- Thyroid Cancer Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Echinoderm biology and ecology
- Pancreatic and Hepatic Oncology Research
- Cancer-related gene regulation
- Erythropoietin and Anemia Treatment
University of Wisconsin–Madison
2013-2020
Marshfield Clinic
2019
Center for Human Genetics
2019
UnityPoint Health Meriter
2018
Abstract Medullary thyroid cancer ( MTC ) is an aggressive neuroendocrine tumor NET ). Previous research has shown that activation of N otch signaling a suppressor role in s. The potential therapeutic effect thiocoraline on the pathway cell line TT was investigated. Thiocoraline isolated from marine bacterium V errucosispora sp. MTT assay (3‐[4, 5‐dimethylthiazole‐2‐yl]‐2, 5‐diphenyltetrazolium bromide) used to determine IC 50 value and measure proliferation. W estern blot revealed...
Objective Obesity during pregnancy impedes fetal iron endowment. In adults, both depletion and hypoxia stimulate erythropoietin (Epo) production, while hepcidin, the primary regulator, is inhibited by Epo stimulated obesity. To understand this relationship in fetuses, we investigated obesity, inflammation, status on hepcidin levels. Study Design Epo, C-reactive protein (CRP), ferritin levels were measured 201 newborns of 35 to 40 weeks' gestation with historical risk factors for a low...
Elizabeth McPherson, MD*, Colin Korlesky, BS† and Scott Hebbring, PhD* *Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, Wisconsin USA †Department of Pediatrics, University School Medicine Public Health, Madison, Wisconsin, Corresponding Author: MD, Center 1000 N. Oak Avenue, WI 54449, Tel: (715) 615-5522, Email: mcpherson.elizabeth{at}marshfieldresearch.org
Abstract Introduction: Carcinoids are neuroendocrine (NE) tumors that secrete hormones causing the carcinoid syndrome. Metastatic carcinoids not amenable to curative surgery. Our previous research has shown Notch signaling a tumor suppressor role in NE tumors. In present study, we sought examine Thailandepsin A (TDP-A), newly discovered HDAC inhibitor as activating drug and cancer agent. Methods: TDP-A is bacterial natural product isolated from fermentation broth of Burkholderia...