A5074788913- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Colorectal and Anal Carcinomas
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Cancer-related gene regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bariatric Surgery and Outcomes
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Anorectal Disease Treatments and Outcomes
- Stoma care and complications
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Minimally Invasive Surgical Techniques
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Ferroptosis and cancer prognosis
Yangzhou University
2016-2025
Northern Jiangsu People's Hospital
2012-2025
Dalian Medical University
2016-2025
Xuzhou Medical College
2025
Hubei University of Arts and Science
2015-2024
Xiangyang Central Hospital
2015-2024
Nanjing University
2023-2024
Nanjing Medical University
2003-2024
People's Hospital of Kaizhou District
2014-2018
Creative Research Enterprises (United States)
2018
Galectin-1, an evolutionarily conserved glycan-binding protein with angiogenic potential, was recently identified as being overexpressed in cancer-associated fibroblasts (CAFs) of gastric cancer. The role endogenous CAF-derived galectin-1 on angiogenesis cancer and the mechanism involved remain unknown.Immunohistochemical staining used to investigate correlation between vascular endothelial growth factor (VEGF) CD31 expression tissues normal tissues. Galectin-1 knocked down CAFs isolated...
fecal DNA is a novel molecular biomarker of CRC and carries high potential for the remote detection premalignant lesions as noninvasive screening method.
Purpose: The aim of this study was to investigate the diagnostic and prognostic significance methylation status secreted frizzled-related protein 2 (SFRP2) in colorectal cancer (CRC). Methods: Methylation-specific PCR assay performed analyze SFRP2 promoter solid tissue, stool serum samples collected from 169 CRC patients, 63 patients with advanced adenomas, 46 non-adenomatous polyps 30 normal healthy controls. Results: Methylated frequently detected tissues precancerous lesions. sensitivity...
Abstract Background As a novel class of non-coding RNAs, circular RNAs (circRNAs) are key regulators the development and progression different cancers. However, little is known about function biological mechanism circLMTK2, also named hsa_circ_0001725, in gastric cancer (GC) tumourigenesis. Methods circLMTK2 was identified ten paired specimens adjacent normal tissues by RNA sequencing genome-wide bioinformatic analysis verified quantitative real-time PCR (qRT-PCR). Knockdown or exogenous...
Abstract Resistance to oxaliplatin (OXA) is a major cause of recurrence in gastric cancer (GC) patients. Autophagy an important factor ensuring the survival cells under chemotherapeutic stress. We aimed investigate role OXA‐related genes autophagy and chemoresistance cells. established OXA‐resistant used RNA‐seq profile gene expression within GC corresponding parental Immunohistochemistry RT‐qPCR was performed detect tissues two cohorts patients who received OXA‐based chemotherapy. The...
HER-2/neu and VEGF expression is correlated with disease behaviors in various cancers. However, evidence for their colon cancer rather contradictory both the protein status prognostic value. found to participate regulation, has known correlation some tumors. In this study, we investigated Chinese patients explored whether there was any between patterns.HER-2/neu were immunohistochemically using tumor samples obtained from 317 all stages. Correlation of degree staining clinicopathological...
Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which thought to contribute this tumor's malignant behavior. Epithelial-mesenchymal transition (EMT) regarded as a crucial contributing factor progression. Galectin-1 (Gal-1), β-galactoside-binding protein abundantly expressed in activated cancer-associated fibroblasts (CAFs), has been reported be involved GC progression and metastasis binding β1 integrin, which, turn, can bind matrix proteins activate...
Galectin-1, a β-galactoside-binding protein implicated in cancer cell immune privilege, was highly expressed activated pancreatic stellate cells (PSCs). This study designed to investigate the relationship between PSC-derived galectin-1 and tumor immunity cancer. Isolated PSCs were identified as normal pancreas (hNPSCs) or (hCaPSCs) by immunohistochemical staining for α-SMA vimentin, expression evaluated Western blotting quantitative RT-PCR. Apoptosis, caspase activity, cytokine production...
// Yang Chong 1 , Dong Tang Jun Gao Xuetong Jiang Chuanqi Xu Qingquan Xiong Yuqin Huang Jie Wang Huaicheng Zhou Youquan Shi Daorong Department of Gastrointestinal Surgery, Clinical Medical College Yangzhou University, Subei People's Hospital Jiangsu Province, 225001, China Correspondence to: Wang, email: daorong666@sina.com Keywords: galectin-1, epithelial-mesenchymal transition, hedgehog signaling, Gli-1, gastric cancer Received: May 20, 2016 Accepted: October 21, Published: November 08,...
Abstract Colorectal cancer (CRC) is the third most common malignant tumor worldwide and a serious threat to human health. MicroRNAs (miRNAs) play key role in oncogenesis progression. MiRNA-125 (miR-125) an important miRNA that dysregulated several kinds of cancers. Thus, we investigated expression effects miR-125 Transcriptional co-activator with PDZ-binding motif (TAZ) for better understanding underlying mechanism progression CRC, which may provide emerging biomarker diagnosis treatment...