A5101653586- Galectins and Cancer Biology
- Wound Healing and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Signaling Pathways in Disease
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Antimicrobial agents and applications
- Stoma care and complications
- Management of metastatic bone disease
- Anorectal Disease Treatments and Outcomes
- NF-κB Signaling Pathways
- Macrophage Migration Inhibitory Factor
- Sirtuins and Resveratrol in Medicine
- Graphene and Nanomaterials Applications
- Colorectal and Anal Carcinomas
Yangzhou University
2015-2025
Tongji University
2025
Shaanxi Provincial People's Hospital
2021
Shanxi Medical University
2021
Taizhou People's Hospital
2020
Nantong University
2020
Harbin Medical University
2014-2018
First Affiliated Hospital of Harbin Medical University
2014-2018
People's Hospital of Kaizhou District
2016
Union Hospital
2013
Galectin-1, an evolutionarily conserved glycan-binding protein with angiogenic potential, was recently identified as being overexpressed in cancer-associated fibroblasts (CAFs) of gastric cancer. The role endogenous CAF-derived galectin-1 on angiogenesis cancer and the mechanism involved remain unknown.Immunohistochemical staining used to investigate correlation between vascular endothelial growth factor (VEGF) CD31 expression tissues normal tissues. Galectin-1 knocked down CAFs isolated...
Integrins are heterodimers composed of non-covalently associated alpha and beta subunits that mediate the dynamic linkage between extracellular adhesion molecules intracellular actin cytoskeleton. present in various tissues organs involved different physiological pathological molecular responses vivo . Wound healing is an important process recovery from traumatic diseases consists three overlapping phases: inflammation, proliferation, remodeling. Integrin regulation acts throughout wound to...
Deregulated microRNAs and their roles in tumorigenesis have attracted much attention recent years. Although miR-503 was shown to be important tumorigenesis, its role osteosarcoma remains unknown. In this study, we focused on the expression mechanisms of development. We found that down-regulated cell lines primary tumor samples, restoration reduced proliferation, migration invasion. Low level patients with associated considerably shortened disease-free survival. Furthermore, bioinformatic...
Gastric cancer (GC) is characterized by the excessive deposition of extracellular matrix, which thought to contribute this tumor's malignant behavior. Epithelial-mesenchymal transition (EMT) regarded as a crucial contributing factor progression. Galectin-1 (Gal-1), β-galactoside-binding protein abundantly expressed in activated cancer-associated fibroblasts (CAFs), has been reported be involved GC progression and metastasis binding β1 integrin, which, turn, can bind matrix proteins activate...
Galectin-1, a β-galactoside-binding protein implicated in cancer cell immune privilege, was highly expressed activated pancreatic stellate cells (PSCs). This study designed to investigate the relationship between PSC-derived galectin-1 and tumor immunity cancer. Isolated PSCs were identified as normal pancreas (hNPSCs) or (hCaPSCs) by immunohistochemical staining for α-SMA vimentin, expression evaluated Western blotting quantitative RT-PCR. Apoptosis, caspase activity, cytokine production...
// Yang Chong 1 , Dong Tang Jun Gao Xuetong Jiang Chuanqi Xu Qingquan Xiong Yuqin Huang Jie Wang Huaicheng Zhou Youquan Shi Daorong Department of Gastrointestinal Surgery, Clinical Medical College Yangzhou University, Subei People's Hospital Jiangsu Province, 225001, China Correspondence to: Wang, email: daorong666@sina.com Keywords: galectin-1, epithelial-mesenchymal transition, hedgehog signaling, Gli-1, gastric cancer Received: May 20, 2016 Accepted: October 21, Published: November 08,...
The treatment of osteoporosis typically inhibits the activity osteoclasts, which subsequently results in suppression bone formation and maintenance, however underlying mechanism remains to be elucidated. receptor activator nuclear factor κ‑B ligand (RANKL)‑receptor (RANK) signaling axis is important osteoblast regulation osteoclasts. RANKL surface‑bound molecules expressed on T cells stimulate a reverse transduction order regulate cells, therefore present study hypothesized that osteoblasts...
Hypertension is the most prevalent chronic disease globally and treatment control ratio of hypertension patients are still low. The function lncRNA MIR210HG in has not yet been announced. Eighty-three 79 healthy individuals were enrolled. Human Umbilical Vein Endothelial Cells (HUVECs) treated with Ang II employed to imitate hypertension. relative expression miR-125b-5p evaluated by qRT-PCR while ROC curve was applied assess diagnostic performance MIR210HG. CCK-8 assay performed detect...
// Dong Tang 1, * , Jingqiu Zhang Zhongxu Yuan 2, Hongpeng 1 Yang Chong Yuqin Huang Jie Wang Qingquan Xiong Sen 3 Qi Wu 4 Ying Tian Yongdie Lu Xiao Ge Wenjing Shen and Daorong Department of General Surgery, Institute Northern Jiangsu Province Hospital, Clinical Medical College, Yangzhou University, Yangzhou, P.R. China 2 Anhui No. Provincial People’s Hefei, Province, The First Affiliated Hospital Nanjing Nanjing, Medicine, College These authors have contributed equally to this work...
Galectin-1 (GAL-1), which is encoded by LGALS1, promotes vasculogenic mimicry (VM) in gastric cancer (GC) tissue. However, the underlying mechanism remains unclear.Immunohistochemical (IHC) and CD34-periodic acid-Schiff (PAS) double staining were used to investigate Glioma-associated oncogene-1(GLI1) expression VM paraffin-embedded sections from 127 patients with GC of all tumor stages. LGALS1 or GLI1 stably transduced into MGC-803 cells AGS cells, western blotting, IHC, CD34-PAS...
Deregulated expression of miRNAs contributes to the development osteosarcoma. Our previous study has showed that miR-503 was downregulated in osteosarcoma tissues. However, mechanism still remains largely undefined. In our study, we found overexpression suppressed cell invasion and migration inhibited epithelial-to-mesenchymal transition (EMT) MG-63. Furthermore, identified c-myb, an oncogene, a direct target miR-503. Moreover, c-myb could rescue miR-503-suppressed EMT. The upregulated...
Abstract Osteosarcoma is the most common malignant bone cancer that mainly affects children and young adults. Recently, NAD + ‐dependent deacetylase, sirtuin 1 (SIRT1), has been reported to play a key role in development of tumors. The study aimed investigate SIRT1 osteosarcoma explore its underlying oncogenic mechanisms. prognostic value was assessed through detection expression based on biopsy tissue. Then, further effect osteosarcoma, cells were treated with small interfering RNA...
Gastric cancer ranks as one of the most prevalent cancers worldwide. While incidence gastric in Western countries has notably diminished over past century, it continues to be a leading cause cancer‑related mortality on global scale. The majority humans are attributed chronic <em>Helicobacter pylori</em> infection and progression is often preceded by gastritis, atrophy, metaplasia dysplasia. However, precise mechanisms underlying development remain ambiguous, including formation polyps...
As a newly discovered cancer-related molecule, we explored the unreported mechanism of LINC01615 intervention in colon cancer.LINC01615 expression clinical samples and cells were detected. Effects silencing/overexpression on malignant development cancer analyzed through cell function experiments. Changes at level molecular biology detected by quantitative real-time polymerase chain reaction Western blot. Bioinformatics analysis dual luciferase reporter assay involved display verification...
Objective To explore the optimal management strategies for unresectable advanced pancreatic head carcinoma without preoperative gastric outlet obstruction(GOO).Methods Clinical data of 441 cases GOO undergoing surgery from Jan 2001 to Dec 2010 were analyzed retrospectively.Results Among GOO,101 patients received simple Roux-en-Y cholecystojejunostomy (group A),133 choledochojejunostomy B),83 combined gastrojejunostomy(group C) and other 124 gastrojejunostomy D).The postoperative recurrent...
Objective To investigate factors associated with postoperative recurrence and prognosis in gastric gastrointestinal stromal tumors(gastric GIST). Methods Clinical data of 107 patients GIST who underwent surgical resection at the Zhejiang Province Hospital Integrated Traditional Chinese Western Medicine between January 1987 December 2008 were analyzed retrospectively. Factors explored. Results Surgery was radical 83 patients(radical group) palliative 24 patients(palliative group). Thirty-one...
Objective To investigate the safety and feasibility of reversed π-shaped esophagojejunal anastomosis in laparoscope-assisted total gastrectomy (LATG) for gastric cancer (GC). Methods The retrospective corss-sectional study was conducted. The clinicopathological data 18 GC patients who were admitted to Subei People′s Hospital Jiangsu Province between January 2015 October 2016 collected. All underwent LATG, surgical procedures included free stomach lymph node dissection firstly,...