A5041739072- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Medicinal Plants and Neuroprotection
- Acute Kidney Injury Research
- Dermatology and Skin Diseases
- Reproductive Biology and Fertility
- Immune Response and Inflammation
- RNA Research and Splicing
- Petroleum Processing and Analysis
- Cancer, Lipids, and Metabolism
- Hemodynamic Monitoring and Therapy
- Drug Transport and Resistance Mechanisms
- Ginger and Zingiberaceae research
- Allergic Rhinitis and Sensitization
- Spine and Intervertebral Disc Pathology
- Industrial Technology and Control Systems
- Respiratory Support and Mechanisms
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Medical Imaging and Analysis
- Healthcare and Venom Research
- Prostate Cancer Treatment and Research
- Alkaloids: synthesis and pharmacology
- Dialysis and Renal Disease Management
Chinese University of Hong Kong
2011-2024
Shanxi Medical University
2021-2024
Shaanxi Provincial People's Hospital
2021-2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
First Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
Hebei Medical University
2020-2022
Wuhan Third Hospital
2022
Tongren Hospital
2022
Abstract Mitochondrial metabolic capacity and DNA replication have both been shown to affect oocyte quality, but it is unclear which one more critical. In this study, immature oocytes were treated with FCCP or ddC independently inhibit the respective mitochondrial of during in vitro maturation. To differentiate their roles, we evaluated various parameters related maturation (germinal vesicle break down nuclear maturation), quality (spindle formation, chromosome alignment, distribution...
Uncaria rhynchophylla is a component herb of many Chinese herbal formulae for the treatment neurodegenerative diseases. Previous study in our laboratory has demonstrated that an ethanol extract ameliorated cognitive deficits mouse model Alzheimer's disease induced by D-galactose. However, active ingredients responsible anti-Alzheimer's activity have not been identified. This aims to identify bioassay-guided fractionation approach and explore acting mechanism these using well-established...
The present study was designed to determine whether controlled ovarian hyperstimulation (COH) and in vitro maturation (IVM), two common clinical procedures human IVF treatment, have an impact on mitochondrial DNA (mtDNA) copy number function oocytes. Matured mouse oocytes recovered following COH, IVM natural cycles (NC), which simulated those treatments clinic treatment. copies of mtDNA, the activity mitochondria as determined by inner membrane potential oocyte adenosine trisphosphate (ATP)...
Abstract Background Uncaria tomentosa , which has similar chemical constituents with rhynchophylla, been reported to alleviate cognitive impairments in Alzheimer’s disease (AD) animal models. This study aimed compare the and anti-AD effect of ethanol extracts U. (UTE) rhynchophylla (URE). Methods The high-performance liquid chromatography (HPLC) was used UTE URE. Streptozotocin (STZ) intracerebroventricularly (ICV) injected into adult male Sprague–Dawley (SD) rats establish AD model. (400...
Abstract Background Psoriasis is a long-term inflammatory skin disease. A novel herbal formula containing nine Chinese medicines, named Inflammation Skin Disease Formula (ISDF), has been prescribed in clinics for decades. Aims To investigate the efficacy and action mechanisms of ISDF on psoriasis using imiquimod (IMQ) Interleukin-23 (IL-23)-induced models mice reveal pharmacokinetics profile rats. Methods Topical administration IMQ intradermal injection with IL-23 respectively induced...
α-Solanine, the most important and active component of Solanum nigrum, was found to have anti-cancer activity on multiple cancer cells. However, its effects colorectal (CRC) associated molecular mechanisms remain be further elucidated.In this study, we investigated α-solanine against CRC cells in vitro vivo.Cell viability measured using Cell Counting Kit-8 (CCK-8) assay; cell cycle analyzed with a Cycletest Plus DNA Reagent Kit; apoptosis detected by flow cytometer; migration invasive...
Ibuprofen, a medication in the nonsteroidal anti-inflammatory drug class, is widely used for treating inflammatory diseases such as osteoarthritis. It has been shown recent years that ibuprofen strong effect on Ras homolog gene family, member A (RhoA) inhibition multiple cell types. Our previous finding also demonstrated interleukin-1β (IL-1β) increases filamentous actin (F-actin) of chondrocytes via RhoA pathway. Therefore, we hypothesized may suppress IL-1β-induced F-actin upregulation by...
The circular RNA, hsa_circ_0057452, is highly expressed in keloids, but its specific mechanism of action remains unknown. levels microRNA (miR)-1225-3p, and AF4/FMR2 family member 4 (AFF4) keloid tissues fibroblasts (KFs) were determined using quantitative reverse transcription-polymerase chain reaction. Changes KFs viability, proliferation, apoptosis, migration investigated the cell counting kit-8, bromodeoxyuridine, flow cytometry, Transwell assays. Luciferase, RNA immunoprecipitation,...
Abstract Background Qing-Zao-Jiu-Fei Decoction (QZJFD) is a famous herbal formula commonly prescribed for the treatment of lung-related diseases in ancient and modern times. Trichosanthis Fructus (TF) Fritillariae Thunbergii Bulbus (FTB) are widely used cough pulmonary disease. In order to identify more effective fibrosis, we intend add TF FTB QZJFD form modified (MQZJFD). this study, aims explore MQZJFD as an innovative therapeutic agent fibrosis using bleomycin (BLM)-treated rats unravel...
Thymosin beta 10 (TMSB10) overexpression is a general characteristic in human carcinogenesis. It involved the malignant process of generating multiple cancers. However, there are only few reports about TMSB10 colorectal cancer (CRC) and mechanism its carcinogenetic effect still poorly understood. The present study intends to clarify biological roles carcinogenic CRC explore possibility whether might be useful as non-invasive serum tumor biomarker detecting CRC. Immunohistochemical results...
As a newly discovered cancer-related molecule, we explored the unreported mechanism of LINC01615 intervention in colon cancer.LINC01615 expression clinical samples and cells were detected. Effects silencing/overexpression on malignant development cancer analyzed through cell function experiments. Changes at level molecular biology detected by quantitative real-time polymerase chain reaction Western blot. Bioinformatics analysis dual luciferase reporter assay involved display verification...
Objective To investigate the diagnostic performances of renal resistive index (RRI) and semiquantitative power Doppler ultrasound (PDU) scores in predicting acute kidney injury (AKI) stage 3 critically ill patients.Methods This prospective observational study included 148 patients (80 with reduced cardiac [CI], 68 maintained CI). RRI PDU were measured within 6 h after intensive care unit admission. AKI was defined according to Kidney Disease Improving Global Outcomes criteria.Results A...
Our previous study revealed that Epimedii Folium (EF) and Codonopsis Radix (CNR) significantly promoted tumor growth on a subcutaneous mouse model of prostate cancer (PCa) via enhancing the mRNA protein expressions androgen receptor (AR), while Astragali (AGR) inhibited suppressing expression AR. In present study, we aimed to investigate potential interactions between EF, CNR or AGR AR antagonist (abiraterone acetate [ABI]) using orthotopic PCa models. CNR, ABI were intragastrically given...