A5021750559- Cancer Cells and Metastasis
- Zebrafish Biomedical Research Applications
- Pregnancy-related medical research
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Effects and risks of endocrine disrupting chemicals
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- RNA Research and Splicing
- Reproductive biology and impacts on aquatic species
- Glycosylation and Glycoproteins Research
- Synthesis and biological activity
- Environmental Toxicology and Ecotoxicology
- Diabetes and associated disorders
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Reproductive Physiology in Livestock
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Multiple Myeloma Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Molecular Biology Techniques and Applications
- Synthesis and Reactions of Organic Compounds
Yichang Central People's Hospital
2018-2024
China Three Gorges University
2018-2024
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2019-2024
Tianjin Institute of Pharmaceutical Research (China)
2010-2024
Wenzhou Medical University
2013-2023
National Time Service Center
2019-2021
Chinese Academy of Sciences
2019-2021
Xi'an Institute of Optics and Precision Mechanics
2020-2021
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2019
Tianjin University
2016-2017
Abstract Mitochondrial metabolic capacity and DNA replication have both been shown to affect oocyte quality, but it is unclear which one more critical. In this study, immature oocytes were treated with FCCP or ddC independently inhibit the respective mitochondrial of during in vitro maturation. To differentiate their roles, we evaluated various parameters related maturation (germinal vesicle break down nuclear maturation), quality (spindle formation, chromosome alignment, distribution...
ABSTRACT Cardiovascular toxicity is a major challenge for the pharmaceutical industry and predictive screening models to identify eliminate pharmaceuticals with potential cause cardiovascular in humans are urgently needed. In this study, taking advantage of transparency larval zebrafish, Danio rerio , we assessed seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine verapamil hydrochloride) two non‐cardiovascular...
Resolvin D1 (7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid) (RvD1), generated from ω-3 fatty docosahexaenoic acids, is believed to exert anti-inflammatory properties including inhibition of neutrophil activation and regulating inflammatory cytokines. In this study, we sought investigate the effect RvD1 in modulating alveolar fluid clearance (AFC) on LPS-induced acute lung injury. vivo, was injected i.v. (5 μg/kg) 8 h after LPS (20 mg/kg) administration, which markedly...
Retinitis pigmentosa (RP) is characterized by degeneration of the retinal photoreceptors and leading cause inherited blindness worldwide. Although few genes are known to autosomal recessive RP (arRP), a large proportion disease-causing remain be revealed. Here we report identification SLC7A14, potential cationic transporter, as novel gene linked arRP. Using exome sequencing direct screening 248 unrelated patients with arRP, find that mutations in SLC7A14 account for 2% cases We further...
Antibody-drug conjugate (ADC) is a novel class of therapeutics for cancer target therapy. This study assessed antitumor activity ADC with an antimitotic agent, monomethyl auristatin E (MMAE) and humanized monoclonal anti-HER2 antibody, hertuzumab, in gastric cancer. The efficacy hertuzumab-MC-Val-Cit-PAB-MMAE (hertuzumab-vcMMAE) on human epidermal growth factor receptor 2 (HER2) positive cells, NCI-N87, was evaluated vitro vivo. cytotoxicity hertuzumab significantly enhanced after...
The islet in type 2 diabetes (T2DM) and the brain neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (IAPP) T2DM). Excessive activation Ca(2+)-sensitive protease calpain-2 has been implicated as a mediator oligomer-induced death dysfunction diseases. To establish if human IAPP toxicity is mediated by comparable mechanism, we overexpressed rat insulinoma cells freshly isolated...
Type 2 diabetes involves aberrant misfolding of human islet amyloid polypeptide (h-IAPP) and resultant pancreatic deposits. Curcumin, a biphenolic small molecule, has offered potential benefits in other protein diseases, such as Alzheimer's disease. Our aim was to investigate whether curcumin alters h-IAPP protects from cellular toxicity at physiologically relevant concentrations. The effect on vitro investigated by electron paramagnetic resonance spectroscopy, ThT fluorescence microscopy....
Edema fluid resorption is critical for gas exchange, and both alveolar epithelial sodium channel (ENaC) Na,K-ATPase are accredited with key roles in the resolution of pulmonary edema. Alveolar clearance (AFC) was measured situ ventilated lungs by instilling isosmolar 5% BSA solution Evans Blue-labeled albumin tracer (5 ml/kg) measuring change concentration over time. Treatment lipoxin A4 receptor agonist (5(S), 6(R)-7-trihydroxymethyl 17 heptanoate) significantly stimulated AFC oleic acid...
// Chaolin Huang 1 , Yuanhong Chen Hang Liu Jing Yang Xuejing Song Junping Zhao Na He Chengji J. Zhou 2 Yongping Wang Changjiang and Qiaoxiang Dong Institute of Environmental Safety Human Health, School Laboratory Medicine Life Science, Wenzhou Medical University, 325035, P.R. China Department Biochemistry Molecular Medicine, University California at Davis, Sacramento, CA 95817, USA Correspondence to: Dong, email: dqxdong@163.com Huang, cjhuang5711@163.com Keywords: CSCs; celecoxib; PGE ;...
Multiple myeloma (MM) is still an incurable malignancy of plasma cells. Proteasome inhibitors (PIs) work as the backbone agent and have greatly improved outcome in majority newly diagnosed patients with myeloma. However, drug resistance remains major obstacle causing treatment failure clinical practice. Here, we investigated effects Indirubin-3'-monoxime (I3MO), one derivatives Indirubin, MM.MM patient primary samples human cell lines were examined. I3MO on underling molecular mechanisms via...
Bisphenol A (BPA) is widely acknowledged as an endocrine disruptor, and its toxicological effects have garnered considerable research interest. In this investigation, a soil pot experiment was conducted to examine the consequences of sustained BPA exposure on growth soybean seedlings, transcriptome, endophytic bacterial community. We observed substantial inhibition in seedling growth. Transcriptome analysis showed that growth-related genes both leaves roots were markedly downregulated...
Abstract Bifenthrin (BF) is a synthetic pyrethroid that targets the nervous system of insects and may have adverse effects on behavior development nontarget organisms. However, no reports been issued different enantiomers locomotor for pyrethroids (SPs) in zebrafish, whether activity associated with developmental toxicities remains unclear. In this study, enantioselectivity BF (1 S 1 R ) acute embryonic–larval zebrafish were first evaluated. The results indicated ‐BF was more toxic, causing...
Cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 has recently been linked to type 2 diabetes by genome-wide association studies. While CDK5 and its p35 are both expressed display enzymatic activity in pancreatic β-cells, their precise role the β-cell remains unknown. Because is characterized a deficit mass increased apoptosis, we investigated of survival.We used INS 832/13 cells, rat islets isolated from wild-type or human islet amyloid polypeptide (h-IAPP)...
Retinoic signaling plays an important role in cell proliferation and differentiation. Disruption of retinoic via excessive or deficient acid can cause teratogenic effects on developing embryos. Similar to acid, many xenobiotic environmental pollutants have been found disrupt through binding eliciting agonistic activity receptors. Currently, studies acid-like compounds aquatic organisms mainly focused teratogenicity few explored their neurobehavioral toxicity. In the present study, authors...