A5101617919- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Venous Thromboembolism Diagnosis and Management
- Gestational Diabetes Research and Management
- Hormonal and reproductive studies
- Assisted Reproductive Technology and Twin Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Maternal and fetal healthcare
- Menopause: Health Impacts and Treatments
- Aldose Reductase and Taurine
- Network Security and Intrusion Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Ion channel regulation and function
- Prenatal Screening and Diagnostics
- Ovarian function and disorders
- Quinazolinone synthesis and applications
- Viral Infections and Outbreaks Research
- Tea Polyphenols and Effects
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
- Thermoregulation and physiological responses
- Animal Nutrition and Physiology
- Connexins and lens biology
University Hospital Galway
2025
Wenzhou Medical University
2012-2024
West China Second University Hospital of Sichuan University
2023-2024
Sichuan University
2023-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2024
Harbin Veterinary Research Institute
2022
Chinese Academy of Agricultural Sciences
2022
Peking University
2003-2021
Harbin Medical University
2021
Third Affiliated Hospital of Harbin Medical University
2021
Abstract Mitochondrial metabolic capacity and DNA replication have both been shown to affect oocyte quality, but it is unclear which one more critical. In this study, immature oocytes were treated with FCCP or ddC independently inhibit the respective mitochondrial of during in vitro maturation. To differentiate their roles, we evaluated various parameters related maturation (germinal vesicle break down nuclear maturation), quality (spindle formation, chromosome alignment, distribution...
An increase in cytosolic Ca2+ via a capacitative calcium entry (CCE)-mediated pathway, attributed to members of the transient receptor potential (TRP) superfamily, TRPC1 and TRPC3, has been reported play an important role regulating cardiomyocyte hypertrophy. Increased also plays critical mediating cell death response ischemia-reperfusion (I/R). Therefore, we tested hypothesis that overexpression TRPC3 cardiomyocytes will sensitivity I/R injury. Adult isolated from wild-type (WT) mice...
The present study was designed to determine whether controlled ovarian hyperstimulation (COH) and in vitro maturation (IVM), two common clinical procedures human IVF treatment, have an impact on mitochondrial DNA (mtDNA) copy number function oocytes. Matured mouse oocytes recovered following COH, IVM natural cycles (NC), which simulated those treatments clinic treatment. copies of mtDNA, the activity mitochondria as determined by inner membrane potential oocyte adenosine trisphosphate (ATP)...
UCP2 plays a physiological role by regulating mitochondrial biogenesis, maintaining energy balance, ROS elimination, and cellular autophagy in numerous tissues. But the exact roles of cumulus cells are still not clear. Genipin, special inhibitor, was added into cultural medium to explore human cells. There were no significant differences ATP membrane potential levels from inhibiting groups as compared with control. The Mn-SOD markedly elevated after inhibited Genipin. However, ratio reduced...
Severe acute respiratory syndrome (SARS) is a highly contagious zoonotic disease caused by SARS coronavirus (SARS-CoV). Since its outbreak in Guangdong Province of China 2002, has 8096 infections and 774 deaths December 31st, 2003. Although there have been no more cases reported human populations since 2004, the recent emergence novel (COVID-19) indicates potential recurrence other among humans. Thus, developing rapid response vaccine to provide protection for still needed. Spike (S) protein...
The primary function of testicular Leydig cells (LCs) is to produce testosterone (T). In vitro culture the represents a very important approach study androgen production and its regulations. Various methods have been developed for enrichment from testes. However, getting in large numbers with high purity viability still challenging. Here, we describe new way isolate LCs rat testes quantity viability.Enzymatic digested adult rats were labelled prolactin receptor (PRLR) antibody. positive...
Abstract Background The objective of this study was to analyze the accuracy gadolinium–ethoxybenzyl–diethylenetriamine penta–acetic acid enhanced magnetic resonance imaging (Gd–EOB–DTPA–MRI) for predicting microvascular invasion (MVI) in patients with small hepatocellular carcinoma (sHCC) preoperatively. Methods A total 60 sHCC performed preoperative Gd–EOB–DTPA–MRI Harbin Medical University Cancer Hospital from October 2018 2019 were involved study. Univariate and multivariate analyses by...
Testosterone deficiency, or hypogonadism, occurs when the body does not produce enough testosterone, primary male sex hormone. This can lead to physical, emotional, and cognitive symptoms that affect quality of life, including decreased libido, erectile dysfunction, fatigue, depression, reduced muscle mass. Causes include ageing, specific medical conditions such as diabetes, obesity, systemic diseases, damage testes. Numerous studies have indicated testosterone levels start decrease in men...
Background The basal luteinizing hormone (LH) and the prior LH to follicle-stimulating (FSH) ratio (LH/FSH) in polycystic ovarian syndrome (PCOS) are generally higher than those non-PCOS patients general population. potential negative effects of elevated on human reproductive function highly controversial, as down-regulation function. purpose this study was evaluate effect LH/FSH live birth rate PCOS undergoing vitro fertilization (IVF) cycles. Methods A retrospective analysis conducted 698...
Deficient spermatozoon motility is one of the main causes male infertility. However, there are still no accurate and effective treatments in a clinical setting for asthenospermia. Exploring genes mechanism asthenospermia has become hot topics reproductive medicine. Our aim to study effect SLRIP on human oxidative stress.Sperm samples were collected including normospermia group (60 cases) an (50 cases). SLIRP protein expression spermatozoa was examined by western blotting, relative mRNA...
Abstract Objective : To determine the gene sequence and tissue distribution of uncoupling protein 3 ( Ucp 3) in collared lemming, we quantified mRNA expression under known states altered energy expenditure (photoperiod‐induced weight gain loss, cold exposure, fasting) measured mitochondrial oxygen consumption to assess possible functional changes expenditure. Research Methods Procedures The information was obtained using reverse transcription‐polymerase chain reaction rapid amplification...
Background. The effects of different testicular sperm extraction methods on the embryonic development and clinical outcome azoospermic men in intracytoplasmic injection (ICSI) cycles have not been researched. Our goal was to evaluate effect retrieval used for patients with OA or NOA outcomes during ICSI cycles. Methods. This a retrospective cohort study. A total 530 who underwent 570 met study criteria. performed using by TESA 282 (TESA group); mTESE due 90 (mTESE MESA 198 (MESA group)....
Recent studies suggest that autophagy plays an important role in the response of heart to increased stress including pressure overload hypertrophy. As diabetic patients exhibit a higher incidence failure and mortality than non‐diabetics, particularly presence hypertension, we hypothesized this might be due abnormal autophagic response. Therefore, young male rats were divided into control (CON; 12% kcal fat/19% protein/69% carbohydrate), high fat diet (HF; 60/19/21%) type 2 (DIA; + low dose...