A5101536869- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Sperm and Testicular Function
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Testicular diseases and treatments
- Thermoregulation and physiological responses
- Cancer-related gene regulation
- Uterine Myomas and Treatments
- Laser Applications in Dentistry and Medicine
- Retinal Diseases and Treatments
- Ovarian cancer diagnosis and treatment
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Anesthesia and Pain Management
- Sexual Differentiation and Disorders
- Nausea and vomiting management
- Circular RNAs in diseases
Wenzhou Medical University
2014-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2024
The First People’s Hospital of Lianyungang
2019
Army Medical University
2015-2018
Southwest Hospital
2015-2018
Zhengzhou University
2008-2017
Huazhong University of Science and Technology
2005
Second Military Medical University
2002-2003
First Affiliated Hospital of Chengdu Medical College
2000
Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that noncoding RNAs, including microRNAs long play important roles in development endometriosis.Expression profiling miRNAs endometrial tissue was using microarrays. The most differentially expressed were confirmed quantitative reverse transcriptase-polymerase chain reaction analysis additional...
Abstract Long noncoding RNA s (lnc s), a novel class of transcripts that have critical roles in carcinogenesis and progression, emerged as important gene expression modulators. Recent evidence indicates lnc taurine‐upregulated 1 ( TUG 1) functions an oncogene numerous types human cancers. However, its function the development cervical cancer remains unknown. The aim this research was to investigate clinical significance biological cancer. found be significantly upregulated tissues four cell...
The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) a promising option diabetes and its complications. In this pilot clinical trial, we evaluated the safety efficacy of intravenous autologous bone marrow MSCs (ABMSC) DR.In total, 34 eyes with non-proliferative or proliferative DR (NPDR, n = 19; PDR, 15) from 17 patients were analyzed. Treatment involved one infusion 3 × 106/kg ABSMCs. patients' vital signs monitored, along immune allergic reactions....
Diabetes triggers abnormal ovarian follicular development and consequently leads to infertility.Here, we established a type 2 diabetes mouse model by feeding with high fat diet (HFD) for 15/20 weeks assessed the effect of on angiogenesis.After fed HFD 15 weeks, mice had characteristics diabetes, which was much more serious after 20 HFD.After HFD, shown morphology hyaline appearance, less blood vessel, arrest granulosa cells (GCs) in mature follicles, but not ovaries from HFD.Elevated makers...
Abstract Single-port laparoscopy has gained more attention, but inherent technical challenges hinder its wider use. To overcome the disadvantage of traditional single-port surgery, robotic laparoendoscopic single-site surgery system was designed and clinically utilized. This multi-center single-arm trial aimed to present clinical outcomes SHURUI endoscopic system. 63 women with ovary cysts, myoma, cervical epithelial neoplasm, or endometrial carcinoma were recruited at 6 academic medical...
Objective To investigate the modulation of microRNAs (miRNAs) upon neuronal differentiation mesenchymal stem cells (MSCs) through targeting RE-1 Silencing Factor (REST), a mature gene suppressor in and un-neuronal cells. Methods Rat bone marrow derived–MSCs were induced into neuron-like (MSC-NCs) by DMSO BHA vitro. The expression neuron specific enolase (NSE), microtubule-associated protein tau (Tau), REST its target genes, including synaptosomal-associated 25 (SNAP25) L1 cell adhesion...
Nucleotide excision repair (NER), the core mechanism of DNA pathway, was commonly used to maintain genomic stability and prevent tumorigenesis. Previous investigations have demonstrated that single nucleotide polymorphisms (SNPs) NER pathway genes were associated with various types cancer. However, there no research elucidating genetic association entire ovarian cancer susceptibility. Therefore, we conducted genotyping for 17 SNPs six (XPA, XPC, XPG, ERCC1, ERCC2, ERCC4) in 89 cases 356...
MicroRNAs (miRNAs) play an important role in drug resistance and modulate the efficiency of chemotherapy. A recent study indicated that miR-340 functions as a tumor suppressor various types cancer. However, chemotherapy has not been reported yet. In this study, we found enhanced cisplatin (CDDP)-induced cell death. Induction miR-340-5p expression decreased IC50 CDDP increased apoptosis CDDP-resistant MG-63 Saos-2 cells. Moreover, accumulation MRP1 MDR1. We further explored mechanism...
Stem Leydig cells (SLCs) play a critical role in the development and maintenance of adult cell (ALC) population. SLCs also are present testis. Their identification, characteristics, regulation testis remain uncertain. Using single-cell RNA-seq, we found that mesenchymal stromal population may be involved ALC regeneration. Upon elimination, fraction begins to proliferate while different differentiate ALCs. Transcriptomic analysis identified five clusters can classified into two major groups...
MicroRNA (miR)-29a has been associated with carcinogenesis in humans; however, its functional significance esophageal squamous cell carcinoma (ESCC) is yet to be determined. In the present study, expression of miR-29a was markedly downregulated ESCC tissue and TE-1 line, compared normal cells. Furthermore, study identified that forced cells significantly reduced proliferation migration. overexpression did not affect Notch1, it increase gene levels hairy enhancer split 1 (Hes1), which key...
Spermatogenesis is an efficient, complex, and highly organized proliferation differentiation process that relies on multiple factors including testosterone produced by the Leydig cells. Although critical role played in spermatogenesis well recognized, mechanism which it works still not completely understood, partially due to inability specifically precisely monitor testosterone-dependent changes within developing germ Here we present single-cell RNA sequencing data from10,983 adult rat...
Background Testosterone plays a critical role in maintaining reproductive functions and well-beings of the males. Adult testicular Leydig cells (LCs) produce testosterone are generated from stem (SLCs) during puberty through adulthood. In addition, macrophages SLC regulatory niche for normal function. Age-related reduction serum contributes to number metabolic quality-of-life changes males, as well age-related immunological functions. How aging may affect function is still unclear. Methods...