A5015215985- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- Hippo pathway signaling and YAP/TAZ
- Retinal Development and Disorders
- Calpain Protease Function and Regulation
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Corneal Surgery and Treatments
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Heavy Metal Exposure and Toxicity
- Neurogenesis and neuroplasticity mechanisms
- Retinopathy of Prematurity Studies
- Advanced Nanomaterials in Catalysis
- Dental Implant Techniques and Outcomes
- Air Quality and Health Impacts
- Olfactory and Sensory Function Studies
- Dental materials and restorations
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Connexins and lens biology
- Wnt/β-catenin signaling in development and cancer
- Nanoparticles: synthesis and applications
- Endodontics and Root Canal Treatments
- Cancer, Hypoxia, and Metabolism
Army Medical University
2016-2024
Southwest Hospital
2016-2024
Modifications of protein post-translation are critical modulatory processes, which alters target biological activity，function and/or location, even involved in pathogenesis some diseases. So far, there at least 16 types modifications identified, particularly through recent mass spectrometry analysis. Among them, succinylation (Ksuc) on lysine residues causes a variety changes. Succinylation proteins contributes to many cellular processes such as proliferation, growth, differentiation,...
The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) a promising option diabetes and its complications. In this pilot clinical trial, we evaluated the safety efficacy of intravenous autologous bone marrow MSCs (ABMSC) DR.In total, 34 eyes with non-proliferative or proliferative DR (NPDR, n = 19; PDR, 15) from 17 patients were analyzed. Treatment involved one infusion 3 × 106/kg ABSMCs. patients' vital signs monitored, along immune allergic reactions....
It aims to explore the toxicity and mechanism of large-surface-area MSiNPs MSiNPs-Ag<sup>+</sup> exposed hCEC cells cornea. A protein corona-based therapy was proposed treat induced corneal damage dry eye.
Retinitis pigmentosa initially presents as night blindness owing to defects in rods, and the secondary degeneration of cones ultimately leads blindness. Previous studies have identified active roles microglia pathogenesis photoreceptor RP. However, contribution remains controversial, partly due limited knowledge microglial phenotypes during Rationale: In this study, we investigated pathways activation its Methods: A classic RP model, Royal College Surgeons rat, was used explore process...
Regeneration/repair after injury can be endowed by adult stem cells (ASCs) or lineage restricted and even terminally differentiated cells. In corneal epithelium, regeneration a large wound depends on ASCs (limbal epithelial cells, LESCs), whereas repair small is LESCs-independent. Here, using rat wounds with different sizes, we show that YAP activation promotes the expansion of LESCs wound, as well reprogramming local (repairing cells) which contributes to LESCs-dependent -independent...
Diabetic retinopathy (DR), one of the leading causes vision loss worldwide, is characterized by neurovascular disorders. Emerging evidence has demonstrated retinal neurodegeneration in early pathogenesis DR, and no treatment been developed to prevent neurodegenerative changes that precede detectable microvascular Bone marrow CD133 + stem cells with revascularization properties exhibit neuroregenerative potential. However, whether can ameliorate at stage DR remains unclear. In this study,...
Background aimsMesenchymal stromal cells (MSCs) hold great promise in the treatment of diabetic retinopathy (DR), as evidenced by increasing preclinical and clinical studies. However, absence standardized industrialized clinical-grade donor hampers continued development large-scale application MSCs-based therapies for DR. Previously, we have identified a unique population MSCs generated from human embryonic stem cell (hESC) line under Good Manufacturing Practice conditions that could be...
Olfactory ensheathing cells (OECs) are heterogeneous in morphology, antigenic profiles and functions, these OEC subpopulations have shown different outcomes following transplantation for central nervous system (CNS) injuries. Morphologically, OECs divided into two subpopulations, process-bearing (Schwann cells-like) flattened (astrocytes-like) OECs, which could switch between each other affected by extracellular intracellular factors. However, neither the relationship morphology function of...
To explore the effects of αA-crystallin in astrocyte gliosis after optic nerve crush (ONC) and mechanism α-crystallin neuroprotection axon regeneration.ONC was established on Sprague-Dawley rat model (10(-4) g/L, 4 µL) intravitreously injected into model. Flash-visual evoked potential (F-VEP) examined 14d ONC, glial fibrillary acidic protein (GFAP) levels retina site were analyzed 1, 3, 5, 7 ONC by immunohistochemistry (IHC) Western blot respectively. The beta Tubulin (TUJ1),...
Remodeling of extracellular matrix (ECM) components endothelial cells is the main cause retinal vascular basement membrane (BM) thickening, which leads to initiation and perpetuation microvasculopathy diabetic retinopathy (DR). Excessive amounts glucocorticoids (GCs) are related presence severity DR, however transcriptional effects GCs on biology human capillary (HRCECs) its impacts DR still unclear. Here, we showed that GC (hydrocortisone) treatment induced ECM component [fibronectin (FN)...
Background Glial scaring induced by the activation and proliferation of astrocytes after optical nerve damage is one causes neural axons difficult to regeneration.Researches showed that α-crystallin can promote regeneration pass through zone retinal ganglion cells (RGCs) axons, we speculate protect tissue against process. Objective This study was investigate influence for secretion inflammatory factors astrocytes. Methods Optical nerver isolated from 3-5 day-old SPF Long Evans...