A5100461665- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Photoacoustic and Ultrasonic Imaging
- Advancements in Solid Oxide Fuel Cells
- Nanopore and Nanochannel Transport Studies
- Quantum Dots Synthesis And Properties
- Supramolecular Self-Assembly in Materials
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Graphene and Nanomaterials Applications
- Electronic and Structural Properties of Oxides
- Nonlinear Optical Materials Studies
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Photochromic and Fluorescence Chemistry
- Extracellular vesicles in disease
- Carbon and Quantum Dots Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Fuel Cells and Related Materials
- Advanced Biosensing Techniques and Applications
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- Micro and Nano Robotics
- Catalysis and Oxidation Reactions
Wuhan National Laboratory for Optoelectronics
2016-2025
Huazhong University of Science and Technology
2016-2025
Lanzhou University
2024
Union Hospital
2024
First Affiliated Hospital of Xinjiang Medical University
2024
Xinjiang Medical University
2024
Changzhou No.2 People's Hospital
2024
Lanzhou University Second Hospital
2024
Jinggangshan University
2024
Southwest Medical University
2024
Non-invasive sonodynamic therapy (SDT) was developed because of its advantages high penetration depth and low side effects; however, tumor hypoxia greatly restricts therapeutic effect. In this study, we aimed to develop ideal O2 self-supplementing nanoparticles for imaging-guided enhanced tumors with the adept coalescence biology nanotechnology. Methods: Based on natural enzyme system red blood cells (RBC), biomimetic (QD@P)Rs were fabricated by encapsulating Ag2S quantum dots (QD) in RBC...
Chemodynamic therapy (CDT) is widely explored for tumor-specific by converting endogenous H2O2 to lethal ·OH destroy cancer cells. However, scavenging glutathione (GSH) and insufficient intratumoral levels seriously hinder the application of CDT. Herein, we reported fabrication copper ion-doped ZIF-8 loaded with gold nanozymes doxorubicin hydrochloride (DOX) chemotherapy CDT synergistic treatment tumors assistance tumor microenvironment (TME)-activated fluorescence imaging. The Cu2+-doped...
Abstract Slow oxygen reduction reaction (ORR) involving proton transport remains the limiting factor for electrochemical performance of proton-conducting cathodes. To further reduce operating temperature protonic ceramic fuel cells (PCFCs), developing triple-conducting cathodes with excellent is required. In this study, K-doped BaCo 0.4 Fe Zr 0.2 O 3− δ (BCFZ442) series were developed and used as PCFCs, their crystal structure, conductivity, hydration capability, characterized in detail....
Metal "X" Frameworks (MXFs) constructed from metal ions and biomacromolecules ("X components") via coordination interactions show crystalline structures diverse functionalities. Here, a series of MXFs composed various (e.g., Zn2+, Hf4+, Ca2+) DNA oligodeoxynucleotides were reported. With MXF consisting Hf4+ CpG as the example, we that such Hf-CpG can achieve high-Z elements-enhanced photon radiotherapy further trigger robust tumor-specific immune responses, thus showing efficient tumor...
Abstract Inefficient tumour treatment approaches often cause fatal metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and macrophage membrane. Co-MOF degradation in the microenvironment releases Co 2+ , which results downregulation of HSP90 expression inhibition cellular heat resistance, thereby improving photothermal therapy effect PDA. H 2 S...
Accurate analysis of microRNAs (miRNAs) at the single-cell level is extremely important for deeply understanding their multiple and intricate biological functions. Despite some advancements in analyzing miRNAs, challenges such as intracellular interferences insufficient detection limits still remain. In this work, an ultrasensitive nanopore sensor quantitative miRNA-155 constructed based on ionic current rectification (ICR) coupled with enzyme-free catalytic hairpin assembly (CHA)....
We functionalized double-walled carbon nanotubes (DWCNTs) as artificial water channel proteins. For the first time, molecular dynamics simulations show that bilayer structure of DWCNTs is advantageous for nanotube based transmembrane channels. The shielding amphiphilic outer layer could guarantee biocompatibility synthetic and protect inner tube (functional part) from disturbance membrane environment. This novel design promote more sophisticated nanobiodevices which function in a...
A high quantum yield (4.3%) hybrid nanogel system based on engineered polypeptides and Ag2S dots has been developed as a multifunctional diagnostic therapeutic agent for targeted second near-infrared fluorescence, photoacoustic imaging, photothermal therapy.
Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as susceptible agent is introduced for enhancing selectivity targeting MWTT. ILs/PDA nanocomposites have an excellent heating efficiency under ultralow power irradiation. Encouraging antitumor effect was observed when tumor bearing mice received...
This work introduces a significant Co-free cathode material for proton-conducting solid oxide fuel cells (H-SOFCs) and offers deep understanding of the effect K-doping on ability absorption transportation oxygen ions protons.
Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by cells resist under specific mechanisms. Inhibiting copper transporter ATPase (ATP7A) was found to disrupt ion homeostasis, thereby enhancing the effect cuproptosis and eventually inhibiting invasion metastasis. In this study, we develop a multifunctional nanoplatfrom based on Cu9S8 (CAPSH), designed enhance in specifically targeting ATP7A interference, while combining thermodynamic...
A new type of multifunctional quantum dot (QD)-polypeptide hybrid nanogel with targeted imaging and drug delivery properties has been developed by metal-affinity driven self-assembly between artificial polypeptides CdSe-ZnS core-shell QDs. On the surface QDs, a tunable sandwich-like microstructure consisting two hydrophobic layers one hydrophilic layer them was verified capillary electrophoresis, transmission electron microscopy, dynamic light scattering measurements. Hydrophobic drugs can...
Safe multifunctional nanoplatforms that have multiple therapeutic functions integrated with imaging capabilities are highly desired for biomedical applications. In this paper, targeted chemo-photothermal synergistic therapy and photoacoustic/computed tomography of tumors were achieved by one novel nanoprobe (GMS/DOX@SLB-FA); it was composed a gold nanostar core doxorubicin (DOX)-loaded mesoporous silica shell (GMS), which coated folic acid (FA)-modified thermosensitively supported lipid...
Abstract High‐security nanoplatform with enhanced therapy compliance is extremely promising for tumor. Herein, using a simple and high‐efficient self‐assembly method, novel active‐targeting nanocluster probe, namely, Ag 2 S/chlorin e6 (Ce6)/DOX@DSPE‐mPEG 2000 ‐folate (ACD‐FA) synthesized. Experiments indicate that ACD‐FA capable of specifically labeling tumor guiding targeting ablation the via precise positioning from fluorescence photoacoustic imaging. Importantly, probe endowed...
Currently, a large number of anti-tumor drug delivery systems have been widely used in cancer therapy.However, due to the molecular complexity and multidrug resistance tumors, monotherapies remain suboptimal.Thus, this study aimed develop multifunctional theranostic nanoplatform for effective therapy.Methods: Folic acid-modified silver sulfide@mesoporous silica core-shell nanoparticle was first modified with desthiobiotin (db) on surface, then doxorubicin (DOX) loaded into pore.Avidin...
Doxorubicin-loaded ionic liquid–polydopamine (IL–PDA–DOX) nanocomposites were obtained with high antitumor efficacy for combined chemotherapy and microwave thermal therapy of cancer.
Abstract Multifunctional nanoprobes that can be applied for real‐time monitoring or precision treatment of tumors have received wide interest among researchers. However, most these are obtained through chemical synthesis, and thereby may contain toxic residues harmful reagents. In this article, a nano‐bismuth‐sphere‐cluster (Bi) is synthesized via one‐step method (after an irradiation with ultra‐violet) then in dual‐mode computed tomography/photoacoustic imaging. Bismuth potassium citrate...