A5100321388- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Pregnancy and preeclampsia studies
- Photoacoustic and Ultrasonic Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Bladder and Urothelial Cancer Treatments
- Microfluidic and Capillary Electrophoresis Applications
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Drug Transport and Resistance Mechanisms
- RNA regulation and disease
- Epigenetics and DNA Methylation
- Biosensors and Analytical Detection
- Advanced Data Compression Techniques
- Adenosine and Purinergic Signaling
- Hydrogen Storage and Materials
- Advanced Nanomaterials in Catalysis
- Ammonia Synthesis and Nitrogen Reduction
- Digital Filter Design and Implementation
- Parallel Computing and Optimization Techniques
- Hydrogels: synthesis, properties, applications
- HER2/EGFR in Cancer Research
- Ferroptosis and cancer prognosis
Fudan University
2014-2023
Tongji University
2023
Tongji Hospital
2023
Sichuan University
2019-2022
Eye & ENT Hospital of Fudan University
2022
State Key Laboratory of Medical Neurobiology
2022
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2021
Wuhu No 1 People's Hospital
2021
State Key Laboratory of Biotherapy
2019
California NanoSystems Institute
2018
Programmable RNA editing tools enable the reversible correction of mutant transcripts, reducing potential risk associated with permanent genetic changes use DNA tools. However, these to treat disease remains unknown. Here, we evaluated therapy Cas13-based base editors in myosin VI p.C442Y heterozygous mutation (Myo6C442Y/+) mouse model that recapitulated phenotypes human dominant-inherited deafness. We first screened several variants and guide RNAs (gRNAs) targeting Myo6C442Y cultured cells...
Abstract CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various disorders by downregulation of related gene expression. Here, we tested this RNA-editing approach on Beethoven ( Bth ) mice, an animal model human DFNA36 due to point mutation in Tmc1 . We first screened 30 sgRNAs cell cultures found that CasRx with sgRNA3 reduced the transcript 90.8%, wild type + 44.3%. then injected newly developed AAV vector...
Large Language Models (LLMs) have achieved impressive results across numerous domains, yet they experience notable deficiencies in legal question-answering tasks. LLMs often generate generalized responses that lack the logical specificity required for expert advice and are prone to hallucination, providing answers appear correct but unreliable. Retrieval-Augmented Generation (RAG) techniques offer partial solutions address this challenge, existing approaches typically focus only on semantic...
Li<sub>3</sub>VO<sub>4</sub> doped MgH<sub>2</sub> exhibits excellent hydrogen storage performance, in which the existence of Li stimulates catalytic activity V, and simultaneously suppresses O.
Functional polymeric microgels have great potential for biomedical applications owing to the outstanding advantages of their well-defined structures and tunable surface properties. However, traditional polymerization methods lack efficient techniques needed fabrication microgels. Herein, we developed a novel technique, reflux-precipitation polymerization, preparation new type monodisperse poly(ethylene glycol methacrylate phosphate) (PEGMP) microgel with spherical structure abundant...
Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure. Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery PPT to cells challenged by cascaded bio-barriers. To effectively deliver cells, a polymeric prodrug micelle (PCDMA) with charge-conversion capability and self-acceleration drug release function are fabricated, which composed pH reactive oxygen species (ROS) sequentially responsive PPT-polymeric an...
Pelitinib is a potent irreversible EGFR TK inhibitor currently in clinical trials for the treatment of lung cancer. Hyperthermia has been applied concomitantly with chemotherapy and radiotherapy to enhance outcome. In this study, we investigated ability combination pelitinib other conventional anticancer drugs specifically target cancer cells up-regulated efflux transporters ABCB1/ABCG2 after hyperthermia as novel way eradicate stem-like responsible recurrence.Alterations intracellular...
Nanorattles, as promising functional hollow nanomaterials, show considerable advantages in a variety of applications for drug delivery, biosensors, and biomedical imaging because their tailored ability both the movable core shell. In this study, we formulate facile controllable route to synthesize monodisperse magnetic nanorattle with an Fe3O4 superparticle poly(vinylsilane) (PVS) outer shell (Fe3O4@air@PVS) using polymer-backbone-transition strategy. process synthesis, besides acting...
The existing approaches to onychomycosis demonstrate limited success since the commonly used oral administration and topical cream only achieve temporary effective drug concentration at fungal infection sites. An ideal therapeutic approach for should have (i) ability introduce antifungal drugs directly infected sites; (ii) finite intradermal sustainable release maintain levels over prolonged time; (iii) a reporter system monitoring maintenance of level; (iv) minimum level inflammatory...
PTX-loaded comblike polymer PAsp-<italic>g</italic>-(PEG-ICG) micelles can effectively kill cancer cells <italic>via</italic> elevated endoplasmic reticulum stress under laser irradiation.
Bladder cancer (BCa) is the most common of human urinary system, and associated with poor patient prognosis a high recurrence rate. Cancer stem cells (CSCs) are primary cause tumor metastasis, possessing self‑renewal properties resistance to radiation therapy. Our previous studies indicated that phosphorylated signal transduction transcription activator 3 (STAT3) may be potential biomarker predict tolerance in patients BCa, following conventional radiotherapy. The aim present study was...
As a bladder-preserving therapy, radiation therapy (RT) has been widely used in the treatment of bladder cancer (BCa) and made great progress past few decades. However, some BCa patients have low RT responsiveness local recurrence rate after could reach 50%. Acquired radio-resistance (ARR) is one important reasons for failure RT. Unfortunately, these ARR cells also lack sensitivity to chemotherapy cause tumor metastasis.
A norepinephrine-loaded nano-system can serve as an effective auxiliary agent for reducing nanodrug clearance by the liver and enhancing tumor therapy.
Background. This study investigated an association between systemic absolute neutrophil count (ANC) and albuminuria in elderly Chinese people. Methods. A cross-sectional was conducted on 2265 participants attending a routine medical examination Minhang District as part of Platform Chronic Disease program. Their drug history, waist circumference, height, blood pressure, fasting glucose, ANC, urine albumin levels were recorded. conformed to the requirements STROBE statement. Results. Of...
Liposomes have been widely used in drug delivery systems because the encapsulation of liposomes changes biological distribution profile and improves therapeutic indices various drugs. Thermosensitive proven to be a precise effective method for cancer therapy many preclinical studies. However, lack specific targeting ability cells limited their application safe efficient chemotherapy.In present study, an ovarian ligand namely WSGFPGVWGASVK (WSG) screened by phage display vivo was grafted on...
Abstract Objective Placenta-derived inflammation plays a vital role in the pathophysiology of gestational diabetes mellitus (GDM). IL-32 is novel pro-inflammatory cytokine and metabolic regulator involved development disease. We investigated effect GDM. Materials Methods First-trimester C-reactive protein (CRP) level was monitored case-control study 186 women with GDM without. Placental tissue lysed analyzed by high-resolution liquid chromatography-tandem mass spectrometry. Circulating...
In this paper, we propose an efficient accelerating architecture for tier-1 coding in JPEG2000. The coding-passes-parallel method is introduced our to accelerate the encoding. A novel named scan-window employed make it convenient encode three passes parallel mode. Therefore, can be encoded using one time of bit-plane scan. processing reduced by more than 70% compared traditional serial architecture. Additionally, a pipelined MQ coder proposed improve throughout. has been implemented SMIC...