A5006078152- Advanced Cellulose Research Studies
- Pluripotent Stem Cells Research
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Polysaccharides and Plant Cell Walls
- Nail Diseases and Treatments
- Laser Applications in Dentistry and Medicine
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
California NanoSystems Institute
2018-2021
University of California, Los Angeles
2018-2021
Center for Special Minimally Invasive and Robotic Surgery
2021
Abstract Tissue engineering approaches, with the goals of replacing or recovering damaged diseased tissues, reconstituting tissues in vitro for disease modeling and drug development, have potential to make significant contributions medicine. Advances stem cell biology, biomaterial synthesis characterization, microscale technologies made engineered a reality. However, classic tools used build lab do not allow complete control behaviors. More recently, synthetic biology principles developed...
The existing approaches to onychomycosis demonstrate limited success since the commonly used oral administration and topical cream only achieve temporary effective drug concentration at fungal infection sites. An ideal therapeutic approach for should have (i) ability introduce antifungal drugs directly infected sites; (ii) finite intradermal sustainable release maintain levels over prolonged time; (iii) a reporter system monitoring maintenance of level; (iv) minimum level inflammatory...
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (CRISPR/Cas9) is an efficient and precise gene-editing technology that offers a versatile solution for establishing treatments directed at genetic diseases. Currently, CRISPR/Cas9 delivery into cells relies primarily on viral vectors, which suffer from limitations in packaging capacity safety concerns. These issues with nonviral strategy are addressed, where Cas9•sgRNA ribonucleoprotein (RNP)...
In article number 1909882, Samad Ahadian, Leonardo Morsut, Ali Khademhosseini, and co-workers highlight the great potential of tissue engineering approaches synthetic biology principles to fabricate biological tissues cellular constructs in a biomimetic precise manner via manipulation cell behavior function. Advanced biomaterials biofabrication tools can also be employed improve functionality engineered for therapeutic vitro applications.