A5010902410- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Dendrimers and Hyperbranched Polymers
- Click Chemistry and Applications
- Graphene and Nanomaterials Applications
- Synthetic Organic Chemistry Methods
- Cancer Research and Treatments
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Biopolymer Synthesis and Applications
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- DNA and Nucleic Acid Chemistry
- Photochromic and Fluorescence Chemistry
- Neurological Disease Mechanisms and Treatments
- Polymer composites and self-healing
- Photodynamic Therapy Research Studies
- Carbon dioxide utilization in catalysis
- Antimicrobial Peptides and Activities
University of Illinois Urbana-Champaign
2016-2025
Westlake University
2023-2025
Second Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2025
Institute for the Future
2025
Institute for Advanced Study
2025
Ningbo Institute of Industrial Technology
2024-2025
Chinese Academy of Sciences
2010-2025
Yunnan University of Traditional Chinese Medicine
2025
Henan University
2024
Targeted uptake of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner represents potentially powerful technology. Using prostate cancer as model, we report docetaxel (Dtxl)-encapsulated formulated with biocompatible and biodegradable poly( d , l -lactic- co -glycolic acid)- block -poly(ethylene glycol) (PLGA- b -PEG) copolymer surface functionalized the A10 2′-fluoropyrimidine RNA aptamers that recognize extracellular domain prostate-specific membrane antigen (PSMA),...
Nanomedicines (NMs) offer new solutions for cancer diagnosis and therapy. However, extension of progression-free interval overall survival time achieved by Food Drug Administration-approved NMs remain modest. To develop next generation to achieve superior anticancer activities, it is crucial investigate understand the correlation between physicochemical properties (particle size in particular) their interactions with biological systems establish criteria NM optimization. Here, we...
Nanomedicine to overcome both systemic and tumor tissue barriers ideally should have a transformable size surface, maintaining certain negative surface charge for prolonged circulation, while reducing smaller switching positive efficient penetration retention in the interstitial space throughout tissue. However, design of such dual-transformable nanomedicine is rarely reported. Here, shell-stacked nanoparticle (SNP) reported, which can undergo remarkable reduction from about 145 40 nm,...
Poly(urea-urethane) thermosets containing the 1-tert-butylethylurea (TBEU) structure feature a reversible dissociation/association process of their covalent linkages under mild conditions. Unlike conventional thermosets, TBEU-based poly(urea-urethane) maintain malleability after curing. Under high temperature (100 °C) and applied pressure (300 kPa), ground TBEU thermoset powder can be remolded to bulk 20 min. As service our authors readers, this journal provides supporting information...
Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolin-aptamer-conjugated, cisplatin-encapsulating liposome system is described. Calcein was incorporated into target MCF-7 cells (see top image) but not LNCaP bottom image). More importantly, extent can be controlled by using complementary DNA aptamer as an antidote. Detailed facts importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, copy-edited or...
Directed differentiation of embryonic stem (ES) cells is useful for creating models human disease and could potentially generate a wide array functional cell types therapeutic applications. Methods to differentiate ES often involve the formation aggregates called embryoid bodies (EBs), which recapitulate early stages development. EBs are typically made from suspension cultures, resulting in heterogeneous structures with range sizes shapes, may influence differentiation. Here, we use...
Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce reticuloendothelial system (RES) clearance during systemic circulation. However, rational design is still needed further improve the in situ penetration efficiency of chemo-drug-loaded delivery-system formulations release profiles at tumor site. Here, a macrophage-membrane-coated nanoparticle developed for tumor-targeted chemotherapy with controlled profile...
When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces targeting capability of surface engineered NPs by screening active sites ligands.
Encapsulation of small-molecule drugs in hydrophobic polymers or amphiphilic copolymers has been extensively used for preparing polymeric nanoparticles (NPs). The loadings and loading efficiencies a wide range NPs, however, tend to be very low. In this Communication, we report strategy prepare NPs with exceptionally high drug (>50%) quantitative efficiency. Specifically, dimeric conjugate bearing trigger-responsive domain was designed as the core-constructing unit NPs. Upon co-precipitation...
Significance Monovalent ions, such as Na + , play important roles in biology, yet few sensors that image intracellular have been reported. Although deoxyribozymes (DNAzymes) shown to be a promising platform for detection of metal most reported DNAzymes require multivalent ions catalytic activity. Existing monovalent ion-responsive poor selectivity low rate, and high ion concentrations function. Here, we report vitro selection the first (to our knowledge) highly selective, sensitive,...
Cell-penetrating peptides (CPPs), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms, from direct entry various endocytotic mechanisms (both receptor independent and dependent), have been observed but how these specific amino acid sequences accomplish effects is unknown. We show CPP can multiplex interactions with membrane, actin cytoskeleton, cell-surface receptors facilitate different translocation pathways under conditions....
Polymers play important roles in the design of delivery nanocarriers for cancer therapies. Polymeric with anticancer drugs conjugated or encapsulated, also known as polymeric nanomedicines, form a variety different architectures including polymer‐drug conjugates, micelles, nanospheres, nanogels, vesicles, and dendrimers. This review focuses on current state preclinical clinical investigations conjugates micelles. Recent progress achieved some promising fields, such site‐specific protein...
Biodegradable electronics represent an emerging class of technology with potential to provide advanced semiconductor functionality in temporary biomedical implants. This work reported a biodegradable primary battery as power source for these systems, which uses metal foils and polyanhydride packages. Monolithically integrating cells yields packs sufficient operate conventional light emitting diodes radio transmitters.
Near-IR fluorescence imaging has great potential for noninvasive in vivo of tumors. In this study, we show the preferential uptake and retention two hepatamethine cyanine dyes, IR-783 MHI-148, tumor cells tissues.IR-783 MHI-148 were investigated their ability to accumulate human cancer cells, xenografts, spontaneous mouse tumors transgenic animals. Time- concentration-dependent dye normal tissues compared, subcellular localization dyes mechanisms evaluated using organelle-specific tracking...
Polymeric micelles are extensively used for the delivery of hydrophobic drugs, which, however, suffer from unsatisfactory drug loading, colloidal uniformity, formulation stability, and release. Herein, we demonstrate a convenient strategy to prepare with ultrahigh loading via incorporation polymer-drug coordination interactions. An amphiphilic copolymer containing pendant phenylboronic acid as electron acceptor unit was synthesized, which afforded donor-acceptor doxorubicin obtain (∼50%),...
Significance Delivery remains a significant challenge for robust implementation of CRISPR/Cas9. We report an efficient CRISPR/Cas9 delivery system comprising PEGylated nanoparticles based on the α-helical polypeptide PPABLG. Assisted by high membrane-penetrating ability polypeptide, P-HNPs achieved cellular internalization and endosomal escape. The could reach 47.3% gene editing in cells, 35% deletion vivo, HeLa tumor growth suppression >71%, demonstrating advantage over existing...