Rapid and effective bone defect repair remains a challenging issue for clinical treatment. Applying biomaterials with endogenous surface potential has been widely studied to enhance regeneration, but how regulate the electric morphology of implanted materials precisely achieve an optimal bioelectric microenvironment is still major challenge. The aim this study develop electroactive that better mimic extracellular regeneration. Hence, MXene/polyvinylidene fluoride (MXene/PVDF) ferroelectric...

Promoting wound repair by external electric field is a proved effective adjuvant but with single effect and needs additional devices. We designed MXene (Ti3C2Tx)-dominated electroactive nanoplatform (named as PM) which could respond to the natural physiological signals in site convert them into microcurrents of multi-intensity. optimized electrical properties charged surface, superior conductivity permittivity. In vitro studies have demonstrated that PM promotes activity functional cells...

The importance of miRNAs in the progression prostate cancer (PCa) has further been supported by finding that have identified as potential oncogenes or tumor suppressors PCa. Indeed, eukaryotes, found to regulate and control gene expression degrading mRNA at post-transcriptional level. In this study, we investigated miR-34 family members, miR-34b miR-34c, different PCa cell lines, discussed molecular mechanism invasion migration cells vitro. difference analyses transcriptome between DU145 PC3...

This study aimed to evaluate the osteogenic performance of allograft particulate bone and cortical blocks combined with xenograft under bovine pericardium membranes, for treating different degrees labial defects in aesthetic zone. Twenty-four patients were divided into two groups based on defect severity (Terheyden 1/4 2/4 groups). The Terheyden group received granular grafts alone, while grafts. Cone beam computed tomography scans taken preoperatively, immediately postoperatively, six...

The oleanane-type triterpene 18β-glycyrrhetinic acid (1) was modified chemically through the introduction of a trihydroxylated A ring and an ester moiety at C-20 to enhance its antibacterial activity. Compounds 22, 23, 25, 28, 29, 31, 32 showed more potent inhibitory activity against Streptomyces scabies than positive control, streptomycin. Additionally, most compound, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant aureus greater that controls. mode action active derivatives...

Multidrug resistance (MDR) is one of the main reasons for tumor chemotherapy failure. Podophyllotoxin (PPT) has been reported that can suppress MDR cancer cell growth; however, effective delivery PPT to cells challenged by cascaded bio-barriers. To effectively deliver cells, a polymeric prodrug micelle (PCDMA) with charge-conversion capability and self-acceleration drug release function are fabricated, which composed pH reactive oxygen species (ROS) sequentially responsive PPT-polymeric an...

The friend leukemia integration 1 (Fli-1) gene is involved in the expression control of key genes multiple pathogenic/physiological processes, including cell growth, differentiation, and apoptosis; this implies that Fli-1 a strong candidate for drug development. In our previous study, 3′,5′-diprenylated chalcone, (E)-1-(2-hydroxy-4-methoxy-3,5-diprenyl) phenyl-3-(3-pyridinyl)-propene-1-one (C10), was identified as novel anti-prostate cancer (PCa) agent. Here, we investigated molecular...

Globally, the incidence and mortality of pancreatic adenocarcinoma (PAAD) have constantly increased. Long non-coding RNAs (lncRNAs) are considered as vital regulators in human cancers. This study aims to elucidate role LINC00941 regulating PAAD progression molecular mechanism.Through database analyses, expression pattern tissues its prognostic value were uncovered. Its level cell lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR). After knockdown LINC00941,...

Skin injuries and drug-resistant bacterial infections pose serious challenges to human health. It is essential establish a novel multifunctional platform with good anti-infection wound-healing abilities. In this study, new MXene-doped composite microneedle (MN) patch excellent mechanical strength photothermal antibacterial ROS removal properties has been developed for infected wound healing. When the MN tips carrying MXene nanosheets are inserted into cuticle of skin, they will quickly...

Esophageal cancer (ESCC) is reported to be the eighth most common malignant tumors worldwide with high mortality. However, functions of majority circRNAs in ESCC requires further explored.This study identified differently expressed 3 paired using RNA-sequencing method. The interactions among circRNAs, miRNAs, and mRNAs were predicted bioinformatics analysis.In this study, method integrated analysis, 418 overexpressed 637 reduced sample identified. Based on mechanism that could play as ceRNAs...

To get inside the properties of N,N-disubstituted Schiff bases, we synthesized three high-yielding benzaldehyde bases. We used reaction between salicylaldehyde and different diamine compounds, including diamine, ethanediamine, o -phenylenediamine, determining structure obtained molecules by nuclear magnetic resonance spectroscopy electrospray ionization mass spectroscopy. thus evaluated microbicidal antitumor activity these showing that salicylaldehyde-hydrazine hydrate base (compound 1a )...

Rate-distortion (R-D) optimization has been widely adopted to improve the coding efficiency on video encoder side. However, there are few studies related modeling R-D characteristics of latest Versatile Video Coding (VVC) reference software. In this paper, we investigate intra-frame VVC by utilizing four traditional machine learning algorithms. We extract highly descriptive features capture relationship between content and model. Moreover, it is applied initial rate control VVC. Experimental...

Glucagon-like peptide 1 receptor (GLP-1R) is an important biomarker for diagnosis and therapy of the endocrine cancers due to overexpression. Recently, in human prostate cancer cell lines was also observed, therefore it may be a potential target disease. 18F-Al-NOTA-MAL-Cys39- exendin-4 holds great promise GLP-1R. Therefore, feasibility 18F-labeled analog imaging investigated.New probe 18F-Al-NOTA-MAL-Cys39-exendin-4 made through one-step fluorination. Prostate PC3 xenograft model mice were...

Nowadays, network security problems are emerging one after another. In the face of these problems, various products have appeared. At same time, deployed in generate a large number events (log files) every day, and how to extract valuable information has become an urgent problem be solved. The purpose this article is study application data mining fusion technology management sensitive center. This first summarizes basic theories fusion, then extends core side-by-side combined with current...

Projective non-negative matrix factorization (PNMF) as a variant of NMF has received considerable attention. However, the existing PNMF methods can be further improved from two aspects. On one hand, square loss function that is intended to measure reconstruction error sensitive noise. other it non-trivial estimate intrinsic manifold feature space in principal manner. So current paper an attempt proposed new method named robust ensemble projective (REPNMF) for image representation....

/melanoma differentiation-associated gene-7 (mda-7), a novel tumor suppressor/cytokine, exerts tumor-selective inhibition of cells growth, induction apoptosis, and suppression angiogenesis in broad spectrum cancer cell types without harming the equivalent normal cells.Moreover, low transcript levels protein expression IL-24 have been found to be significantly associated with unfavorable pathological phenotypes breast tissues.Furthermore, ectopic via transfection plasmid comprising cDNA or...