A5036595509- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Graphene and Nanomaterials Applications
- Dental Radiography and Imaging
- Orthopaedic implants and arthroplasty
- MXene and MAX Phase Materials
- Oral microbiology and periodontitis research
- Nanoplatforms for cancer theranostics
- Dental materials and restorations
- Electrospun Nanofibers in Biomedical Applications
- Reconstructive Surgery and Microvascular Techniques
- Orthodontics and Dentofacial Orthopedics
- Mesenchymal stem cell research
- Orthopedic Infections and Treatments
- Dental Anxiety and Anesthesia Techniques
- Facial Trauma and Fracture Management
- Salivary Gland Disorders and Functions
- Advanced Nanomaterials in Catalysis
- Anesthesia and Pain Management
- dental development and anomalies
- Extracellular vesicles in disease
- Oral and Maxillofacial Pathology
- Tissue Engineering and Regenerative Medicine
- Oral and gingival health research
Sichuan University
2016-2025
State Key Laboratory of Oral Diseases
2014-2024
Stomatology Hospital
2014-2024
West China Hospital of Sichuan University
2010-2024
Fourth Affiliated Hospital of Guangxi Medical University
2008
Purpose: MXenes are two-dimensional (2D) materials that increasingly being applied in biomedical fields. This is ascribed to their good physiochemical properties, unique structure and high biological compatibility. However, the osteogenic activity suitability of these for bone tissue engineering not clearly understood. Thus, aim this study evaluate biocompatibility, osteoinductivity guided regeneration ability Ti 3 C 2 T x MXene vitro vivo. Methods: Multilayered films were prepared...
Grafting of bone-substitute biomaterials plays a vital role in the reconstruction bone defects. However, design bioscaffolds with osteoinductive agents and biomimetic structures for regeneration critical-sized defects is difficult. Ti3C2MXene-belonging to new class 2D nanomaterials-exhibits excellent biocompatibility, antibacterial properties, promotes osteogenesis. its application preparing 3D-printed tissue-engineered scaffolds repairing has not been explored. In this work, Ti3C2MXene was...
Rapid and effective bone defect repair remains a challenging issue for clinical treatment. Applying biomaterials with endogenous surface potential has been widely studied to enhance regeneration, but how regulate the electric morphology of implanted materials precisely achieve an optimal bioelectric microenvironment is still major challenge. The aim this study develop electroactive that better mimic extracellular regeneration. Hence, MXene/polyvinylidene fluoride (MXene/PVDF) ferroelectric...
Abstarct Odontogenic maxillary sinusitis (OMS) is a subtype of (MS). It actually inflammation the sinus that secondary to adjacent infectious dental lesion. Due lack unique clinical features, OMS difficult distinguish from other types rhinosinusitis. Besides, characteristic pathogeny makes it resistant conventional therapies Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists dentists absolutely urgent settle...
Abstract: The aim of this study was to analyze the behavior porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite grafted for bone defect repair through a series biological safety experiments, animal and more than 5-year long clinical follow-up. carried out in accordance with Chinese Guo Biao Tolerancing (GB/T)16886 GB/T16175, revealed that n-HA/PA66 had no cytotoxicity, sensitization effect, pyrogenic reaction, its hemolysis rate 0.59% (less 5%). Rabbit models tibia defects were...
Zirconia, with its excellent mechanical properties, chemical stability, biocompatibility, and negligible thermal conductivity, is ideal for dental orthopedic applications. In addition, the biocompatibility of zirconia has been studied in vivo , no adverse reactions were observed when samples inserted into bone. However, their use controversial among dentists researchers, especially compared mature implants made titanium alloy. The advantages limitations as biomaterials, such implant...
This study aimed to compare the accuracy of fully guided between dynamic and static computer-assisted implant surgery (CAIS) systems for immediate placement in esthetic zone.A total 40 qualified patients requiring zone were randomly equally assigned either CAIS group (n = 20) or groups 20). Global deviations at entry, apex, angular deviation placed planned position measured compared as primary outcomes. Secondary outcomes mesial-distal, labial-palatal, coronal-apical directions.For...
Methicillin-resistant Staphylococcus aureus (MRSA) has become a serious threat to human's health. Recently, photodynamic/photothermal therapy (PDT/PTT) emerged as promising strategies against antibiotics-resistant pathogens due their broad antibacterial spectrum and negligible resistance. In this work, the photosensitizer indocyanine green (ICG) was loaded on graphene oxide (GO) nanosheets with good encapsulation efficiency high 92.31%. Under near-infrared (NIR) irradiation, anti-MRSA of GO...
Promoting wound repair by external electric field is a proved effective adjuvant but with single effect and needs additional devices. We designed MXene (Ti3C2Tx)-dominated electroactive nanoplatform (named as PM) which could respond to the natural physiological signals in site convert them into microcurrents of multi-intensity. optimized electrical properties charged surface, superior conductivity permittivity. In vitro studies have demonstrated that PM promotes activity functional cells...
This study aimed to evaluate the osteogenic performance of allograft particulate bone and cortical blocks combined with xenograft under bovine pericardium membranes, for treating different degrees labial defects in aesthetic zone. Twenty-four patients were divided into two groups based on defect severity (Terheyden 1/4 2/4 groups). The Terheyden group received granular grafts alone, while grafts. Cone beam computed tomography scans taken preoperatively, immediately postoperatively, six...
Abstract Infectious bone defects represent a substantial challenge in clinical practice, necessitating the deployment of advanced therapeutic strategies. This study presents treatment modality that merges mild photothermal therapy hydrogel with pulsed drug delivery mechanism. The system is predicated on matrix thermally responsive, characteristic defect sites, facilitating controlled and site-specific release. cornerstone this incorporation nanoparticles, which are activated within...
The aim of the study was to investigate a porous nanohydroxyapatite/polyamide 66 (n-HA/PA66) scaffold material that implanted into muscle and tibiae 16 New Zealand white rabbits evaluate biocompatibility osteogenesis osteoinductivity materials in vivo. samples were harvested at 2, 4, 12 26 weeks respectively, subjected histological analysis. At 2 weeks, experiment showed detected n-HA/PA66 composite density new bone formation similar surrounding host weeks. indicated three-dimensional pore...
Abstract Background Maxillary sinus elevation is a predictable procedure to vertically enhance bone volume in the posterior maxilla for successful implant placement. It speculated that graft resorption and remodeling which require angiogenesis may be affected by dimensions of maxillary cavity. Purpose The aim this study investigate effect width (SW) on outcomes transcrestal lift with simultaneous placement based cone beam CT ( CBCT ). Materials Methods A total 57 elevated sites 33 patients...
Marginal bone loss during healing exists around non-submerged dental implants. The aim of this study was to identify the relationship between different degrees marginal and salivary microbiome. One hundred patients were recruited, their implants measured using cone beam computed tomography a 3-month period. divided into three groups according severity loss. Saliva samples collected from all subjected analysed 16S MiSeq sequencing. Although overall structure microbial community not...
Abstract Objective: The biosafety and efficacy of silver–hydroxyapatite–titania/polyamide nanocomposite (nAg–HA–TiO 2 /PA) membrane as a guided bone regeneration (GBR) barrier were investigated based on rat subcutaneous critical‐size calvarial defect model. Material methods: Thirty‐six Sprague–Dawley albino rats divided into nAg–HA–TiO /PA test, expanded polytetrafluoroethylene (e‐PTFE) control blank control. Inflammatory response in each group evaluated using morphological, serological,...