To improve the mechanical properties of bone tissue and achieve desired regeneration for orthopedic surgery, newly designed hydroxyapatite/polyurethane (HA/PU) porous scaffolds were developed via in situ polymerization. The results showed that molecular modification PU soft segments by glyceride castor oil (GCO) can increase scaffold compressive strength 48% elastic modulus 96%. When nano-HA (n-HA) particles incorporated into GCO-PU matrix, further increased 49 74%, from 2.91 to 4.34 MPa 95...

The purpose of this study was to fabricate a low-immunogenicity fish collagen (FC) and bioactive nanohydroxyapatite (n-HA) enhanced poly(lactide-co-glycolide) (PLGA) nanofibrous membrane for guided bone regeneration (GBR) via electrospinning. physicochemical properties morphology revealed that FC n-HA particles were homogeneously dispersed in the PLGA fibrous matrix. Notably, formation polymeric chain network due interaction between significantly improved tensile strength membrane....

We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as core significantly improved PLGA-based fibrous scaffold's dimensional maintenance. further utilized fish collagen modify PLGA shell layer (PFC) coaxial fibers loaded baicalin (BA) into PCL (PCL-BA) endow scaffold with more functional biological cues....

The regeneration of oral tissues is a challenging clinical problem because the complex microbial and biological stress environments. Electrospun fibrous scaffolds have attracted significant interest as effective barrier membranes for guided bone (GBR); however, no mature strategy yet exists surface modification fibers to provide versatility satisfy requirements. This study demonstrated practical biosafety strategy: combined use plant polyphenols LL-37 peptides modify fiber endow scaffold...

Abstract Biomaterials can modulate the local immune microenvironments to promote peripheral nerve regeneration. Inspired by spatial orderly distribution and endogenous electric field of fibers, we aimed investigate synergistic effects electrical topological cues on Nerve guidance conduits (NGCs) with aligned electrospun nanofibers were fabricated using a polyurethane copolymer containing conductive aniline trimer degradable L -lysine (PUAT). In vitro experiments showed that PUAT (A-PUAT)...

Oxidative stress induced by reactive oxygen species (ROS) can adversely affect tissue repair, whereas endowing biomaterials with antioxidant activity improve the in vivo microenvironment, thereby promoting angiogenesis and osteogenesis. Accordingly, this study utilized epigallocatechin-3-gallate (EGCG), a material known for its reducing properties, oxidative self-polymerization capability, strong binding characteristics, to modify bioactive core–shell fibrous membrane (10RP-PG). Compared...

Abstract Reconstruction of bone defects by tissue engineered substitutes requires coordinated coupling between osteogenesis and angiogenesis. Basic fibroblast growth factor (bFGF or FGF‐2) is a protein which acts actively in angiogenesis during skeletal healing development. It hypothesized that BMSCs transfected with bFGF can directly stimulate regeneration vascular tissue, subsequently enhance osseous formation remodeling after implantation the bone. This study was designed to examine...

Natural bone is a complex material with well-designed architecture. To achieve successful integration and regeneration, the constituent structure of bone-repairing scaffolds need to be functionalized synergistically based on biomimetics. In this study, hybrid membrane composed chitosan (CS), sodium carboxymethyl cellulose (CMC), nano-hydroxyapatite (n-HA) was curled in concentric manner generate an anisotropic spiral-cylindrical scaffold, compositional structural properties mimicking natural...

The purpose of this study is to construct a guided bone regeneration membrane that similar components and structurally resembles the native extracellular matrix with sufficient antibacterial properties.A novel type biomimetic bioactive silver ion-loaded calcium phosphate/chitosan (Ag-CaP/CS) ability was successfully developed by incorporation CaP via one-step electrospinning method subsequently crosslinked vanillin.Evaluation physicochemical properties revealed fabricated fibrous membranes...

The study suggests a principle for future design and application of bone scaffolds that must have relatively stable osteogenic space scaffold interface, or degradation speed slower than the time reconstruction completion.

The ideal scaffold for bone repair should have a hierarchical pore structure and gradient degradation performance to satisfy the uniform adhesion proliferation of cells in at early stage implantation, as well providing space subsequent regeneration tissue.

Abstract Building of multifunctional coatings in a more effective way is crucial for meeting the multilevel requirements regenerative medicine. Herein, inspired by diatom and mussel, specific but universal approach proposed building on slow‐degradable fast‐degradable scaffolds or various substrates using epigallocatechin gallate (EGCG) polyethyleneimine (PEI) as bridges silicon coupling. The results reveal that polyphenol EGCG facilitates silica precipitation coating topological morphology...

Abstract Nanohydroxyapatite (n‐HA)/zinc oxide (ZnO) complex was synthesized by a direct precipitation method, and the antibacterial capability mechanism of this were investigated in article. Transmission electron microscope (TEM), Fourier transform infrared, X‐ray photoelectronic spectroscopy (XPS), diffraction (XRD) used to analyze materials. In addition, capacity n‐HA/ZnO examined bacteriolytic plate, inhibition effect, rate assays under light or without light. Furthermore, agarose gel...

Abstract This study was to evaluate enhanced bone formation by morphogenetic protein‐7 (BMP‐7) transduced MSCs on nano‐hydroxyapatite/polyamide (n‐HA/PA) composite scaffolds for tissue engineering in repair of mandibular defect. n‐HA/PA were prepared and rabbit separated expanded; then infected with adenoviral‐mediated BMP‐7 vitro . The MSCs‐BMP‐7 seeded the porous scaffolds. Scaffold/MSCs‐BMP‐7 constructs scaffold/MSCs implanted defects rabbits' mandible as experimental groups A ( n = 18) B...

Abstract The purpose of this study is to explore and develop biodegradable scaffold for bone regeneration or tissue engineering with the capacity controlled drug delivery. Ceftazidime as a model was encapsulated in ethyl cellulose (EC) microspheres, which were subsequently incorporated hydroxyapatite/polyurethane (HA/PU) composite generate an antibiotic delivery system. HA/PU scaffolds had interconnected pore network average porosity about 83%. presence microspheres confirmed by scanning...

This study describes a new drug-loaded coating scaffold applied in infection therapy during bone regeneration. Chitosan (CS) containing antibacterial berberine was coated on nano-hydroxyapatite/polyamide66 (n-HA/PA66) to realize regeneration together with antimicrobial properties. The porous fabricated using the phase-inversion method porosity of about 84% and macropore size 400–600 μm. morphology, mechanical properties drug-release behavior were investigated at different ratios chitosan...

Biomaterial scaffolds meant to function as supporting structures osteogenic cells play a pivotal role in bone tissue engineering. Recently, we synthesized an aliphatic polyurethane (PU) scaffold via foaming method using non-toxic components. Through this procedure uniform interconnected porous structure was created. Furthermore, hydroxyapatite (HA) particles were introduced into process increase the bioactivity of PU matrix. To evaluate biological performances these PU-based scaffolds, their...