A5091559007- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Orthopaedic implants and arthroplasty
- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Geochemistry and Elemental Analysis
- Silk-based biomaterials and applications
- Protein Hydrolysis and Bioactive Peptides
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Antimicrobial Peptides and Activities
- 3D Printing in Biomedical Research
- Orthopedic Infections and Treatments
- MXene and MAX Phase Materials
- Bone and Dental Protein Studies
- Osteoarthritis Treatment and Mechanisms
- Hydrogels: synthesis, properties, applications
- Periodontal Regeneration and Treatments
- Soil Carbon and Nitrogen Dynamics
- Advanced Nanomaterials in Catalysis
- Coal and Its By-products
- Bone Metabolism and Diseases
Chengdu Medical College
2025
Chengdu University
2024-2025
Sichuan University
2022-2024
West China Hospital of Sichuan University
2023
The regeneration of oral tissues is a challenging clinical problem because the complex microbial and biological stress environments. Electrospun fibrous scaffolds have attracted significant interest as effective barrier membranes for guided bone (GBR); however, no mature strategy yet exists surface modification fibers to provide versatility satisfy requirements. This study demonstrated practical biosafety strategy: combined use plant polyphenols LL-37 peptides modify fiber endow scaffold...
Oxidative stress induced by reactive oxygen species (ROS) can adversely affect tissue repair, whereas endowing biomaterials with antioxidant activity improve the in vivo microenvironment, thereby promoting angiogenesis and osteogenesis. Accordingly, this study utilized epigallocatechin-3-gallate (EGCG), a material known for its reducing properties, oxidative self-polymerization capability, strong binding characteristics, to modify bioactive core–shell fibrous membrane (10RP-PG). Compared...
Abstract Building of multifunctional coatings in a more effective way is crucial for meeting the multilevel requirements regenerative medicine. Herein, inspired by diatom and mussel, specific but universal approach proposed building on slow‐degradable fast‐degradable scaffolds or various substrates using epigallocatechin gallate (EGCG) polyethyleneimine (PEI) as bridges silicon coupling. The results reveal that polyphenol EGCG facilitates silica precipitation coating topological morphology...
Effective tissue repair relies on the orchestration of different macrophage phenotypes, both M2 phenotype (promotes repair) and M1 (pro-inflammatory) deserve attention. In this study, we propose a sequential immune activation strategy to mediate bone regeneration, by loading lipopolysaccharide (LPS) onto surface strontium (Sr) ions -contained composite scaffold, which was fabricated combining Sr-doped micro/nano-hydroxyapatite (HA) dual degradable matrices polycaprolactone (PCL) poly...
Integrating the therapeutic efficacy of early bacterial clearance, midstage inflammatory remission, and late-stage effective tissue healing is considered a pivotal challenge in symptomatic treatment infected bone defects (IBDs). Herein, microenvironment-adaptive nanoplatform based on sulfur quantum dot (SQD) nanozyme was proposed for whole-stage therapy IBDs by mediating sequence enzyme cascade reactions. The SQD prepared size-engineering modification strategy exhibits enhanced multienzyme...
Abstract The combined design of scaffold structure and multi‐biological factors is a prominent strategy to promote bone regeneration. Herein, composite mesoporous hydroxyapatite (HA) microspheres loaded with the morphogenetic protein‐2 (BMP‐2) poly(DL‐lactic‐co‐glycolic acid) (PLGA) matrix constructed by 3D printing. Furthermore, chemokine stromal cell‐derived factor‐1 α (SDF‐1 ) adsorbed on surface achieve sequential release dual‐biofactors. results indicate that rapid SDF‐1 effectively...
The promotion of vascular network formation in the early stages implantation is considered a prerequisite for successful functional bone regeneration.
Microbial remediation of heavy metals in soil has been widely studied. However, bioremediation efficiency is limited practical applications because nutritional deficiency, low efficiency, and competition with indigenous microorganisms. Herein, we prepared a biochar-based microbial agent (BMA) by immobilizing the (MA) on biochar for U Cd soil. The results showed that BMA amendment significantly enhance organic matter, cation exchange capacity, enzyme activities. availability markedly...