A5100661728- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Fish Biology and Ecology Studies
- Galectins and Cancer Biology
- ATP Synthase and ATPases Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Esophageal Cancer Research and Treatment
- Extracellular vesicles in disease
- Uterine Myomas and Treatments
- Macrophage Migration Inhibitory Factor
- Eating Disorders and Behaviors
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- RNA Research and Splicing
- Signaling Pathways in Disease
- Enzyme Structure and Function
Soochow University
2014-2025
Ningxia Medical University
2025
Second Affiliated Hospital of Soochow University
2024
First Affiliated Hospital of Soochow University
2014-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Zunyi Medical University
2023
Abstract Background Circular RNAs (circRNAs) are regarded as vital regulatory factors in various cancers. However, the biological functions of circDNER paclitaxel (PTX) resistance lung cancer remain largely unexplored. Methods Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) was used to analyze circDNER, miR‐139‐5p, and ITGB8. Cell proliferation assessed via colony formation MTT assays. apoptosis evaluated by flow cytometry. Western blot performed assess protein...
Current research underscores the need to better understand pathogenic mechanisms and treatment strategies for idiopathic pulmonary fibrosis (IPF). This study aimed identify key targets involved in progression of IPF. We employed Mendelian randomization (MR) with three genome-wide association studies four quantitative trait loci datasets driver genes Prioritized were evaluated respiratory insufficiency transplant-free survival. The therapeutic efficacy core gene was validated cellular animal...
Background It is well known that abnormal dietary behavior increases the risk for cardiovascular disease especially if person depressed and/or anxious. The purpose of this study was to construct a moderated mediation model explore roles and family health in mechanism through which depression/anxiety influences Quality life (QoL) patients with disease. Methods A field survey conducted China ultimately included 730 aged 20–60 years. Data were collected using Europe five-dimensional five-level...
Abstract AMP‐activated protein kinase (AMPK) serves as a “supermetabolic regulator” that helps maintain cellular energy homeostasis. However, the role of AMPK in glucose metabolism reprogramming lung cancer remains unclear. Here, our study shows low expression correlates with metastasis and clinicopathologic parameters non–small‐cell cancer. Low significantly enhances Warburg effect HBE A549 cells, which turn induces mesenchymal markers their invasion migration. At mechanistic level,...
To explore the immunoregulatory effects of circ_CELF1 in non-small cell lung cancer (NSCLC).The mRNA level primary tissue samples was analyzed by qRT-PCR. The assays CCK-8, colony formation, wound healing as well Transwell were employed for measurement malignant transformation. murine subcutaneous tumor model used to assess tumorigenesis NSCLC vivo. circRNA precipitation, RNA immunoprecipitation, and luciferase reporter performed study relationship between circ_CELF1, miR-491-5p,...
Understanding the stepwise progression of esophageal squamous cell carcinoma (ESCC) is crucial for developing customized strategies early detection and optimal clinical management. Herein, we aimed to unravel transcriptional immunologic alterations occurring during malignant transformation identify clinically significant biomarkers ESCC. Digital spatial profiling (DSP) was performed on 11 patients with early-stage ESCC (pT1) explore in epithelial, immune cell, non-immune stromal compartments...
Lung adenocarcinoma (LUAD) accounts for ~40% of lung cancer cases, and the 5‐year relative survival rate is no more than 1%. Dysregulation components striatin‐interacting phosphatase kinase (STRIPAK) complexes associated with various diseases, including cancer. Striatin‐interacting protein 2 (STRIP2), also called Fam40b, has been reported to regulate tumor cell growth migration. Here, we investigated role STRIP2 in LUAD growth, migration underlying mechanisms. Analysis data from The Cancer...
Esophageal cancer (ESCC) is reported to be the eighth most common malignant tumors worldwide with high mortality. However, functions of majority circRNAs in ESCC requires further explored.This study identified differently expressed 3 paired using RNA-sequencing method. The interactions among circRNAs, miRNAs, and mRNAs were predicted bioinformatics analysis.In this study, method integrated analysis, 418 overexpressed 637 reduced sample identified. Based on mechanism that could play as ceRNAs...
The aim of the present study was to address effects heat shock protein B6 (HspB6) on tumor growth and metastasis in BALB/c mice. Lewis lung carcinoma (LLC) cells were subcutaneously injected into mice followed by intraperitoneal injection recombinant HspB6 (HspB6 groups) or phosphate‑buffered saline (control groups). Tumor assessed size measurement weighing tumors cervical lymph nodes, respectively. Chemokine expression masses quantified quantitative polymerase chain reaction western...
BACKGROUND: Lung adenocarcinoma (LUAD) is a prevalent form of malignancy globally. Disulfidptosis novel programmed cell death pathway based on disulfide proteins, may have positive impact the development LUAD treatment strategies. OBJECTIVE: To investigate disulfidptosis-related genes (DRGs) prognosis LUAD, developed risk model to facilitate diagnosis and prognostication patients. We also explored ACTN4 as new therapeutic biomarker for LUAD. METHODS: investigated expression patterns DRGs in...
In recent years, there have been increasing reports that dysregulated circular RNAs (circRNAs) play a key role in the carcinogenesis of lung adenocarcinoma (LUAC). However, circRNAs early-stage LUAC is poorly understood.The Gene Expression Omnibus (GEO) database and qRT-PCR were used to verify abnormal expression circRNAs, miRNAs genes tissues. shRNA miRNA inhibitor are designed synthesized knock down circ_104640 microRNA (miR)-145-5p expression. CCK-8 assay, colony formation assay flow...
RIPK1/TAK1 are important for programmed cell death, including liver necroptosis and apoptosis. However, there have been few published reports on the functions of in invertebrates. In this study, full-length ChRIPK1 ChTAK1 were cloned from C. hongkongensis through rapid amplification cDNA ends (RACE) technology. has almost no homology with human RIPK1 lacks a kinase domain at N-terminus but DD RHIM domain. is conserved throughout evolution. qRT‒PCR was used to analyze mRNA expression patterns...
Idiopathic pulmonary fibrosis (IPF) leads to excessive fibrous tissue in the lungs, increasing risk of lung cancer (LC) due heightened fibroblast activity. Advances nucleotide point mutation studies offer insights into fibrosis-to-cancer transitions.
Lung cancer is associated with the greatest number of cancer-related deaths worldwide. adenocarcinoma (LUAD) accounts for 85% all cases lung cancer. Despite recent advances in treatment, 5-year survival rate remains less than 15%. Thus, diagnostic and therapeutic role LUAD remain to be further studied. The prolyl 3-hydroxylase family member 4 (P3H4) involved various cancers, but little known about its LUAD. Our study demonstrated that P3H4 gene was upregulated Clinically, expression...
Lung cancer is one of the most common types and a major contributor to cancer-associated mortalities worldwide. The aim present study was investigate function epididymal protein 3A (EDDM3A) in non-small cell lung (NSCLC). Data from patients with NSCLC were retrieved Cancer Genome Atlas analyzed, differences EDDM3A expression level between 30 tissues matched adjacent non-tumor (>5 cm) assessed via tissue microarray analysis. It revealed that, compared tissues, significantly increased...
Most lung cancer deaths are caused by a distant disseminated disease rather than primary tumors.Understanding the biology behind metastasis (DM) is crucial for effective prediction and reduction of recurrence rates.Genomewide analysis tumor provides new way to explore pathogenesis molecular diagnosis in adenocarcinoma.In our study, total 215 eligible adenocarcinoma patients were enrolled.The DNA was extracted from formalin-fixed paraffin-embedded (FFPE) samples tumors these...
EC (esophageal cancer) is a common cancer among people in the world. The molecular mechanism of FAM196B (family with sequence similarity 196 member B) still unclear. This article aimed to clarify role EC.The expression tissues was detected using qRT-PCR. prognosis patients determined by log-rank kaplan-Meier survival analysis and Cox regression analysis. Furthermore, shRNA used knockdown cell lines. MTT, wound healing assays western blot were determine cells.In our research, we found that...