A5069767459- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Sulfur Compounds in Biology
- Nanoplatforms for cancer theranostics
- Ion Channels and Receptors
- Neurological Disease Mechanisms and Treatments
- Calcium signaling and nucleotide metabolism
- Laser Material Processing Techniques
- Renal Diseases and Glomerulopathies
- Characterization and Applications of Magnetic Nanoparticles
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Endoplasmic Reticulum Stress and Disease
Shanghai Jiao Tong University
2019-2025
Soochow University
2020-2025
First Affiliated Hospital of Soochow University
2020-2025
Renji Hospital
2025
First Affiliated Hospital of Hebei Medical University
2025
Hebei Medical University
2025
Anhui Normal University
2022-2024
Chengdu University of Traditional Chinese Medicine
2024
Shanxi University
2022-2023
Nanjing Medical University
2021-2023
Abstract N 6-Methyladenosine (m6A) is the most abundant modification within diverse RNAs including mRNAs and lncRNAs regulated by a reversible process with important biological functions. Human YTH domain family 2 (YTHDF2) selectively recognized m6A-RNAs to regulate degradation. However, possible regulation of YTHDF2 protein post-translational remains unknown. Here, we show that SUMOylated in vivo vitro at major site K571, which can be induced hypoxia while reduced oxidative stress...
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Introduction Cochlear spiral ganglion neurons (SGNs) could be damaged by ototoxic drug, cisplatin (Cis), during which process autophagy was involved. FAM134B, the first detected endoplasmic reticulum (ER-phagy) receptor, plays an important part in dynamic remodelling of ER, mutation affects sensory and autonomic neurons. However whether FAM134B-mediated ER-phagy involved Cis-induced SGN damage or not unknown. The present study designed to determine FAM134B is expressed SGNs C57BL/6 mice and,...
Abstract Background Circular RNAs (circRNAs) represent a type of endogenous noncoding that are generated by back-splicing events and favor repetitive sequences. Recent studies have reported cancer-associated chromosomal translocations could juxtapose distant complementary intronic sequences, resulting in the aberrant formation circRNAs. However, among fusion genes, only small number circRNAs were found to originate from regions during gene translocation. We question if also partners Methods...
Abstract Background Mixed-lineage leukemia ( MLL ) gene rearrangements trigger aberrant epigenetic modification and expression in hematopoietic stem progenitor cells, which generates one of the most aggressive subtypes with an apex self-renewal. It remains a challenge to directly inhibit rearranged itself because its multiple fusion partners poorly annotated downstream genes proteins; therefore, novel therapeutic targets are urgently needed. Methods qRT-PCR, receiver operating characteristic...
Abstract Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors their downstream genes to promote cancer progression. However, whether how hypoxia regulates overall mRNA homeostasis unclear. Here we show that inhibits global-mRNA decay cells. Mechanistically, interaction AGO2 with LUBAC, linear ubiquitin chain assembly complex, which co-localizes miRNA-induced silencing complex turn catalyzes occurring Met 1 -linked ubiquitination...
// Jianyu Cai 1, * , Xiaohong Xia Yuning Liao Ningning Liu 2 Zhiqiang Guo 1 Jinghong Chen Li Yang Huidan Long Qianqian Xiaolan Zhang Lu Xiao Xuejun Wang 3 Hongbiao Huang and Jinbao Protein Modification Degradation Lab, SKLRD, School of Basic Medical Sciences, The Affiliated Cancer Hospital Guangzhou University, Guangdong 511436, China Institute Cardiovascular Disease, Second Hospital, Guangzhou, 510260, Division Biomedical Sanford Medicine University South Dakota, Vermillion, Dakota 57069,...
Diabetic kidney disease (DKD) is currently one of the leading causes end-stage renal (ESRD). Mitochondrial dysfunction in podocyte involve DKD development. However, whether early mitochondrial stabilization delays or reverses progression has not been elucidated. SS31 a novel tetrapeptide compound that targets inner membrane and protects mitochondria by reducing ROS inhibiting cardiolipin oxidation. Our study discovered might have long-term protection DKD. In this study, we examined...
Polycomb repressive complex 2 (PRC2) is responsible for depositing H3K27me3 and plays essential roles in gene silencing during development cancer. Meanwhile, the nuclear exosome targeting (NEXT) facilitates degradation of numerous noncoding RNAs nucleoplasm. Here we find that functional deficiency NEXT leads to an overall decrease levels. Specifically, ZCCHC8 depletion results significant upregulation nascent long (lncRNAs) containing G-quadruplex (G4) U-Rich motifs (G4/U-Rich lncRNAs). The...
The catalytic efficiency of peroxidase mimic enzymes has not been substantially improved despite the wide variety nanozymes. Here, we report a class highly efficient mimics, platinum Janus nanoparticles (Pt NPs), which are synergy assembled from silica NPs and single-component Pt NPs. exhibit ultrahigh efficiency, with constant (Kcat) as high 5.6 × 105 s–1, is about 50-fold greater than Kcat value traditional 140-fold higher that HRP. Compared NPs, components in could effectively adsorb...
Objective: Investigation of the regulatory mechanisms cell stemness in cholangiocarcinoma (CCA) is essential for developingeffective therapies to improve patient outcomes. The purpose this study was investigate function and mechanismof m6A modifications CCA stemness. Methods: Interleukin 6 (IL-6) treatment used induce an inflammatory response, loss-of-function studies wereconducted using mammosphere culture assays. Chromatin immunoprecipitation, polysome profiling, methylated...
Abstract Triple-negative breast cancer (TNBC) is a heterogeneous malignancy in women. It associated with poor prognosis, aggressive malignant behavior, and limited treatment options. In the ubiquitin‒proteasome system (UPS), deubiquitinases (DUBs) are potential therapeutic targets for various tumors. this study, by performing unbiased siRNA screening, we identified STAMBP, JAMM metalloprotease DUB family, as driver of human TNBC tumor growth. Functionally, knockdown STAMBP inhibited...
CRISPR-mediated epigenome editing enables gene expression regulation without changing the underlying DNA sequence, and thus has vast potential for basic research therapy. Effective selection of a single guide RNA (sgRNA) with high on-target efficiency specificity would facilitate application tools. Here we performed an extensive analysis tools on thousands experimentally examined sites established