A5076774917- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Immune Cell Function and Interaction
- Congenital heart defects research
- Traumatic Brain Injury and Neurovascular Disturbances
- Sirtuins and Resveratrol in Medicine
- RNA and protein synthesis mechanisms
- Advanced Neuroimaging Techniques and Applications
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Retinoids in leukemia and cellular processes
- RNA regulation and disease
- Chemokine receptors and signaling
- Neurological disorders and treatments
- Bone and Joint Diseases
Southeast University
2022-2025
East China Normal University
2024
Guangzhou Institutes of Biomedicine and Health
2024
Chinese Academy of Sciences
2010-2024
Nanjing Drum Tower Hospital
2024
Shanghai East Hospital
2024
Nantong University
2024
Sun Yat-sen University
2013-2024
Qilu University of Technology
2023-2024
Third Affiliated Hospital of Zhengzhou University
2022
Background Tumor-associated macrophages (TAMs) remodel the colorectal cancer (CRC) microenvironment. Yet, findings on role of TAMs in CRC seem to be contradictory compared with other cancers. FoxP3+ regulatory T (Treg)-cells dominantly infiltrate CRC. However, underlying molecular mechanism which may contribute trafficking Treg-cells tumor mass remains unknown. Methodology/Principal Findings was either induced by N-methyl-N-nitrosourea (MNU) and H. pylori or established subcutaneous...
Abstract NF-κB is constitutively activated in psoriatic epidermis. However, how promotes keratinocyte hyperproliferation psoriasis largely unknown. Here we report that the activation triggered by inflammatory cytokines induces transcription of microRNA (miRNA) miR-31, one most dynamic miRNAs identified skin patients and mouse models. The genetic deficiency miR-31 keratinocytes inhibits their hyperproliferation, decreases acanthosis reduces disease severity Furthermore, protein phosphatase 6...
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great importance in different cell contexts. However, only a very small number lncRNAs have been experimentally validated and functionally annotated during human hematopoiesis. Here, we report an lncRNA, HOTAIRM1, which is associated with myeloid differentiation pivotal roles the degradation oncoprotein PML-RARA by regulating autophagy pathways. We first revealed HOTAIRM1 variants expressed at levels cells expression...
Abstract Peripherally derived regulatory T (pT reg ) cell generation requires T-cell receptor (TCR) signalling and the cytokines TGF-β1 IL-2. Here we show that TCR induces microRNA miR-31, which negatively regulates pT -cell generation. miR-31 conditional deletion results in enhanced induction of cells, decreased severity experimental autoimmune encephalomyelitis (EAE). Unexpectedly, identify Gprc5a as a direct target miR-31. is known retinoic acid-inducible protein 3, its deficiency leads...
Abstract Background MicroRNA-133b (miR-133b), which is a muscle-specific microRNA, has been reported to be downregulated in human colorectal carcinoma (CRC) when compared adjacent non-tumor tissue. However, its diagnostic value and role CRC have yet described. CXC chemokine receptor-4 (CXCR4), participates multiple cell processes such as invasion-related signaling pathways, was predicted potential target of miR-133b. The aim this study investigate the associations functions miR-133b CXCR4...
Abstract Background Circular RNAs (circRNAs) represent a type of endogenous noncoding that are generated by back-splicing events and favor repetitive sequences. Recent studies have reported cancer-associated chromosomal translocations could juxtapose distant complementary intronic sequences, resulting in the aberrant formation circRNAs. However, among fusion genes, only small number circRNAs were found to originate from regions during gene translocation. We question if also partners Methods...
Abstract Background Mixed-lineage leukemia ( MLL ) gene rearrangements trigger aberrant epigenetic modification and expression in hematopoietic stem progenitor cells, which generates one of the most aggressive subtypes with an apex self-renewal. It remains a challenge to directly inhibit rearranged itself because its multiple fusion partners poorly annotated downstream genes proteins; therefore, novel therapeutic targets are urgently needed. Methods qRT-PCR, receiver operating characteristic...
Small nucleolar RNAs (snoRNAs) are commonly acknowledged as a class of homogeneous non-coding that guide ribosomal RNA modifications. However, snoRNAs referred to orphans have largely unknown functions. Here, we systematically profile chromatin-associated (casnoRNAs) in mammalian cells and identify subgroup orphan casnoRNAs responding DNA damage stress, among which SNORA73 shows the most marked reduction chromatin enrichment. Downregulated maintains cancer genome stability differentiation...
Abstract Purpose To characterize and compare histological MRI‐based changes within the corpus callosum (CC) in cuprizone mouse model of multiple sclerosis (MS). Materials Methods A total 12 C57/BL6 mice were fed from eight weeks age for four weeks. One cohort six two control scanned with a T2‐weighted (T2W) sequence. The other using dual‐echo sequence T2‐mapping diffusion‐weighted orthogonal diffusion encoding directions to calculate water diffusivities parallel perpendicular CC fiber...
Abstract Psoriasis is a chronic recurrent inflammatory skin disorder characterized by the dysregulated cross-talk between epidermal keratinocytes and immune cells, leading to keratinocyte hyperproliferation. Several studies demonstrated that Wnt pathway genes were differentially expressed in psoriatic plaques likely involved pathophysiology of disease. However, molecular mechanisms underlying signaling regulation hyperplasia psoriasis remain largely unknown. We report expression secreted...
Research Article4 April 2017Open Access Source DataTransparent process RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease Huiyuan Zhu Key Laboratory of Cell Differentiation Apoptosis Chinese Ministry Education, Department Immunology Microbiology, Shanghai Institute Immunology, Jiao Tong University School Medicine (SJTU-SM), Shanghai, China Search for more papers by this author Fangzhou Lou Qianqian Yin Yuanyuan Gao Yang Sun Jing Bai Zhenyao Xu Zhaoyuan...
Long noncoding RNAs (lncRNAs) are usually 5' capped and 3' polyadenylated, similar to most typical mRNAs. However, recent studies revealed a type of snoRNA-related lncRNA with unique structures, leading questions on how they processed work. Here, we identify novel named LNC-SNO49AB containing two C/D box snoRNA sequences, SNORD49A SNORD49B; show that represents an unreported 5'-end m7G 3'-end structure. was found highly expressed in leukemia patient samples, silencing dramatically suppressed...
10-Hydroxy-2-decenoic acid (10-HDA) is an important component of royal jelly, known for its antimicrobial, anti-inflammatory, blood pressure-lowering, and antiradiation effects. Currently, 10-HDA biosynthesis limited by the substrate selectivity acyl-coenzyme A dehydrogenase, which restricts technique to a two-step process. This study aimed develop efficient simplified method synthesizing 10-HDA. In this study, ACOX from Candida tropicalis 1798, catalyzes 10-hydroxydecanoyl coenzyme...
Long non-coding RNAs (lncRNAs) have been recently found to be pervasively transcribed in human genome and link diverse diseases. However, the expression patterns regulatory roles of lncRNAs hematopoietic malignancies not reported. Here, we carried out a genome-wide lncRNA study MLL-rearranged acute lymphoblastic leukemia (MLL-r ALL) established lncRNA/messenger RNA coexpression networks gain insight into biological these dysregulated lncRNAs. We detected number that were differentially...
Despite many attempts to understand mixed-lineage leukemia (MLL leukemia), effective therapies for this disease remain limited. We identified a lysosome-associated membrane protein (LAMP) family member, LAMP5, that is specifically and highly expressed in patients with MLL leukemia. The purpose of the study was demonstrate functional relevance clinical value LAMP5 disease.We first recruited large cohort validate expression evaluate its value. then performed vitro vivo experiments investigate...
Abstract Aberrant chromosomal translocations leading to tumorigenesis have been ascribed the heterogeneously oncogenic functions. However, how fusion transcripts exporting remains be declared. Here, we showed that nuclear speckle-specific long noncoding RNA MALAT1 controls chimeric mRNA export processes and regulates myeloid progenitor cell differentiation in malignant hematopoiesis. We demonstrated mRNAs an m6A-dependent manner thus hematopoietic differentiation. Specifically, reducing or...