A5101756755- Psoriasis: Treatment and Pathogenesis
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Fungal Biology and Applications
- Cardiac Ischemia and Reperfusion
- interferon and immune responses
- T-cell and B-cell Immunology
- 3D Printing in Biomedical Research
- Bone health and treatments
- Circular RNAs in diseases
- Wound Healing and Treatments
- MicroRNA in disease regulation
- Dermatology and Skin Diseases
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Optical Imaging and Spectroscopy Techniques
- Alkaline Phosphatase Research Studies
- Cardiac Arrest and Resuscitation
- Biocrusts and Microbial Ecology
- Seaweed-derived Bioactive Compounds
- Fibroblast Growth Factor Research
- Inflammasome and immune disorders
Shanghai Jiao Tong University
2014-2024
Shanghai Ninth People's Hospital
2024
Shanghai First People's Hospital
2022-2024
Dongbei University of Finance and Economics
2024
Peking University
2015-2024
North China University of Science and Technology
2024
Shanghai Academy of Agricultural Sciences
2022
Shanghai Clinical Research Center
2022
Shanghai Institute of Hematology
2015-2021
Massachusetts Institute of Technology
2020
Abstract NF-κB is constitutively activated in psoriatic epidermis. However, how promotes keratinocyte hyperproliferation psoriasis largely unknown. Here we report that the activation triggered by inflammatory cytokines induces transcription of microRNA (miRNA) miR-31, one most dynamic miRNAs identified skin patients and mouse models. The genetic deficiency miR-31 keratinocytes inhibits their hyperproliferation, decreases acanthosis reduces disease severity Furthermore, protein phosphatase 6...
Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading frames (sORFs), but the coding capacities of these sORFs and functions resulting micropeptides remain elusive. Here, we report that human lncRNA MIR155HG encodes a 17-amino acid micropeptide, which termed miPEP155 (P155). is highly expressed by inflamed antigen-presenting cells, leading to discovery P155 interacts with adenosine 5'-triphosphate binding domain heat shock cognate protein 70 (HSC70), chaperone...
Abstract Peripherally derived regulatory T (pT reg ) cell generation requires T-cell receptor (TCR) signalling and the cytokines TGF-β1 IL-2. Here we show that TCR induces microRNA miR-31, which negatively regulates pT -cell generation. miR-31 conditional deletion results in enhanced induction of cells, decreased severity experimental autoimmune encephalomyelitis (EAE). Unexpectedly, identify Gprc5a as a direct target miR-31. is known retinoic acid-inducible protein 3, its deficiency leads...
Abstract Micropeptides encoded by short open reading frames (sORFs) within long noncoding RNAs (lncRNAs) are beginning to be discovered and characterized as regulators of biological pathological processes. Here, we find that lncRNA Dleu2 encodes a 17-amino-acid micropeptide, which name Dleu2-17aa, is abundantly expressed in T cells. Dleu2-17aa promotes inducible regulatory (iTreg) cell generation interacting with SMAD Family Member 3 (Smad3) enhancing its binding the Foxp3 conserved...
Abstract Psoriasis is a chronic recurrent inflammatory skin disorder characterized by the dysregulated cross-talk between epidermal keratinocytes and immune cells, leading to keratinocyte hyperproliferation. Several studies demonstrated that Wnt pathway genes were differentially expressed in psoriatic plaques likely involved pathophysiology of disease. However, molecular mechanisms underlying signaling regulation hyperplasia psoriasis remain largely unknown. We report expression secreted...
Research Article4 April 2017Open Access Source DataTransparent process RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease Huiyuan Zhu Key Laboratory of Cell Differentiation Apoptosis Chinese Ministry Education, Department Immunology Microbiology, Shanghai Institute Immunology, Jiao Tong University School Medicine (SJTU-SM), Shanghai, China Search for more papers by this author Fangzhou Lou Qianqian Yin Yuanyuan Gao Yang Sun Jing Bai Zhenyao Xu Zhaoyuan...
Abstract Previous studies on the molecular classification of cholangiocarcinoma (CCA) focused certain anatomical sites, and disregarded tissue contamination biases in transcriptomic profiles. We aim to provide universal scheme prognostic biomarker CCAs across locations. Comprehensive bioinformatics analysis is performed data from 438 CCA cases various After excluding tumors showing normal expression patterns, we identify two subtypes subtypes, explore molecular, clinical, microenvironmental...
T helper 17 (Th17) cells play an important role in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Th17 cell differentiation from naïve can be induced vitro by the cytokines transforming growth factor β1 interleukin-6. However, it remains unclear whether other regulatory factors control of cells. Mesenchymal stem (MSCs) have emerged as a promising candidate for inhibiting diseases. Despite fact that several molecules been linked to...
Abstract Protein Phosphatase 6 down-regulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits psoriasis, indicating restoration of protein phosphatase can be rational strategy for psoriasis treatment. Through phenotypic screen, we here identify L-menthol ameliorates psoriasis-like skin inflammation by increasing keratinocytes. Target identification approaches reveal an indispensable role transcription factor hairy and enhancer split 1 governing 6-upregulating...
Low temperature is an important environmental factor that restricts the growth of Stropharia rugosoannulata; however, molecular mechanisms underlying S. rugosoannulata responses to low-temperature stress are largely unknown. In this study, we performed a transcriptome analysis high-sensitivity strain (DQ-1) and low-sensitivity (DQ-3) under stress. The liquid hyphae treated at 25 °C 10 were analyzed by RNA-Seq, total 9499 differentially expressed genes (DEGs) identified. GO KEGG enrichment...
Alzheimer's disease (AD) is a significant global health concern, and it crucial that we find effective methods to prevent or slow down AD progression. Recent studies have highlighted the essential role of blood vessels in clearing Aβ, protein contributes AD. Scientists are exploring biomarkers as potential tool for future diagnosis. One promising method may help remote ischemic conditioning (RIC). RIC involves using sub-lethal ischemic-reperfusion cycles on limbs. However, comprehensive...
BackgroundPsoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) most bioactive ingredient of boswellic acids, group anti-inflammatory and anti-cancer properties. Target identification AKBA metabolomics analysis psoriasis helped elucidate molecular mechanism underlying its effect, provide...
ABSTRACT Objectives The identification of structural variants and single‐nucleotide is essential in finding molecular etiologies monogenic genetic disorders. Whole‐genome sequencing (WGS) becoming more widespread disease diagnosis. However, data on its clinical utility remain limited prenatal practice. We aimed to expand our understanding implementing WGS the diagnosis fetal anomalies. Methods employed trio with a minimum coverage 40× MGI DNBSEQ‐T7 platform cohort 17 fetuses presenting...
Abstract Mesenchymal stem cells (MSCs) have demonstrated promising therapeutic potential for a variety of diseases including autoimmune disorders. A fundamental requirement MSC-mediated in vivo immunosuppression is their effective trafficking. However the mechanism underlying MSC trafficking remains elusive. Here we report that skin-derived MSCs (S-MSCs) secrete high levels interleukin-6 (IL-6) inflammatory conditions. Disruption il6 or its signaling transducer gp130 blocks voltage-gated...
Although accumulating evidence has demonstrated the key roles of enhancers in gene expression regulation, contribution genome-wide enhancer-enhancer interactions to developmental decisions remains unclear. Here we explored cooperative regulation patterns among understand their regulatory mechanism. We first filtered robust embryonic stem cells (ESCs) through integrating bidirectional transcription, genomic location, and epigenetic modification. Genome-wide were then identified based on...
Regulatory T (Treg) cells constitute a dynamic population that is critical in autoimmunity. Treg cell therapies for autoimmune diseases are mainly focused on enhancing their suppressive activities. However, recent studies demonstrated certain inflammatory conditions induce instability with diminished FoxP3 expression and convert them into pathogenic effector cells. Therefore, the identification of novel targets crucial to both function plasticity vital importance development therapeutic...