A5069680463- Peptidase Inhibition and Analysis
- Wnt/β-catenin signaling in development and cancer
- Angiogenesis and VEGF in Cancer
- Pneumocystis jirovecii pneumonia detection and treatment
- Biochemical and Molecular Research
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Lymphatic System and Diseases
- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Metabolism and Genetic Disorders
- Botany, Ecology, and Taxonomy Studies
- Axon Guidance and Neuronal Signaling
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Protease and Inhibitor Mechanisms
- Lysosomal Storage Disorders Research
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Cellular transport and secretion
- Yeasts and Rust Fungi Studies
- Hippo pathway signaling and YAP/TAZ
Boston Children's Hospital
2020-2023
Harvard University
2020-2022
University of Massachusetts Lowell
2014-2021
Boston Children's Museum
2020
University of Hawaii System
1997
Abstract We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong anticancer activity in multiple types cancer cells, especially colorectal cancer. In this report, we provide evidence that OBD9 suppresses growth by interfering Wnt signaling pathway, a main driver cell Specifically, find induces autophagic degradation TNIK (traf2 Nck-interacting kinase), which promotes T-cell factor-4 (TCF4)/beta-catenin–mediated gene...
The progression of cancer from localized to metastatic disease is the primary cause morbidity and mortality. interplay between tumor its microenvironment key driver in this process progression. In order for tumors progress metastasize they must reprogram cells that make up promote growth suppress endogenous defense systems, such as immune inflammatory response. We have previously demonstrated stimulation Tsp-1 (TME) potently inhibits Here, we identify a novel tumor-mediated mechanism...
Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by the side effect. Inhibitors targeting specific Wnt-FZD pair(s) enriched cancer cells may effect, effect narrow-spectrum inhibitors remains to be established vivo. Here, we developed a fragment C . difficile toxin B (TcdB FBD ), which recognizes inhibits subclass FZDs,...
Human endoplasmic reticulum aminopeptidase 1 (ERAP1) is one of two ER luminal aminopeptidases that participate in the final processing peptide precursors and generates N-termini MHC class I-restricted epitopes. In order to investigate interactions its binding site with substrate peptides, X-ray crystallographic analyses have been carried out study structures ERAP1 regulatory (ERAP1_R) domain complex antigenic peptides. Single-chain bimodular constructs various peptides linked C-terminal end...
Abstract Current treatment of triple negative breast cancer patients is hindered by a high incidence chemoresistance (30-50%). The prevailing theory that resistance and subsequent recurrence driven stem cells. Unfortunately, the functional characterization cells at molecular level still incomplete. We show here, within canonical cell population, subset characterized Notch1 expression possesses tumor-initiating property associated with Moreover, tumor initiating these Notch1-expressing...
Abstract In the earliest stages of tumor development, epithelial tumors (carcinomas) are physically confined to area tissue in which they form. These nascent lesions (carcinomas situ) sequestered from parenchyma by basement membrane. Within lie a myriad cell types comprised fibroblasts, immune and inflammatory cells endothelial cells. Upon invasion across membrane into parenchyma, must manipulate expression pro- anti-tumorigenic proteins such that pro-tumorigenic factors produced excess...
Insulin-regulated aminopeptidase (IRAP) in humans is a membrane bound enzyme that has multiple functions. It was first described as companion protein of the insulin-responsive glucose transporter, Glut4, specialized vesicles. The subsequently been shown to be identical oxytocinase/aminopeptidase or angiotensin IV (Ang IV) receptor (AT4 receptor). Some AT4 ligand peptides, such Ang and LVV-hemorphin-7, have act IRAP inhibitors exert memory-enhancing properties. As target for developing...
Abstract BRCA1 germ-line mutations are a major cause of hereditary breast cancer and BRCA1-deficient shares many characteristics as sporadic basal-like (BLBC). Effective therapeutic targets for BLBC remain lacking. By utilizing mouse model based on intraductal injection Krt8-Cre adenovirus to inactivate Brca1 Trp53 in luminal mammary epithelial cells, here we report that the Wnt receptor Frizzled 7 (FZD7) serves biomarker target resulting tumor cells is particularly enriched stem /...
<p>Supplementary figures and table</p>
<p>Supplementary figures and table</p>
<div>Abstract<p>We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong anticancer activity in multiple types cancer cells, especially colorectal cancer. In this report, we provide evidence that OBD9 suppresses growth by interfering Wnt signaling pathway, a main driver cell Specifically, find induces autophagic degradation TNIK (traf2 Nck-interacting kinase), which promotes T-cell factor-4...
<div>Abstract<p>We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong anticancer activity in multiple types cancer cells, especially colorectal cancer. In this report, we provide evidence that OBD9 suppresses growth by interfering Wnt signaling pathway, a main driver cell Specifically, find induces autophagic degradation TNIK (traf2 Nck-interacting kinase), which promotes T-cell factor-4...
Oral squamous cell carcinoma (OSCC) accounts for the majority of all oral malignancies. The overall survival rate patients diagnosed with advanced‐stage OSCC (with metastasis) is only 39%, and prognosis these has not improved dramatically despite advances in chemotherapeutic, radiotherapeutic, surgical protocols. As such, there remains an urgent need to develop new therapies improve outcome. Recently, our laboratory identified Neuropilin‐2 (NRP2) transmembrane receptor as a novel target its...
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. The majority (67%) of patients with this aggressive already exhibit local or distant metastases at time initial diagnosis. Understanding molecular mechanisms that regulate OSCC progression and metastasis paramount to developing novel therapeutic strategies for disease. Enhanced tumor‐associated lymphangiogenesis correlates increased lymph node adversely affects prognosis in OSCC. Neuropilin 2 (NRP2) an endothelial...
Abstract Current treatment of triple negative breast cancer is hindered by a high incidence chemoresistance (30-50%). The prevailing theory that resistance and subsequent recurrence driven stem cells. Unfortunately, the functional characterization cells at molecular level still incomplete. We show here, within canonical cell population (CD24low/CD44+/ESA+) cells, subset characterized Notch1 expression possesses tumor-initiating properties associated with Moreover, tumor initiating property...