A5015634688- Nanopore and Nanochannel Transport Studies
- Nanoparticle-Based Drug Delivery
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Mathematical Modeling in Engineering
- Composite Material Mechanics
- Nanoplatforms for cancer theranostics
- Microfluidic and Bio-sensing Technologies
- Elasticity and Material Modeling
- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Mathematical Biology Tumor Growth
- Electrochemical Analysis and Applications
- Enzyme-mediated dye degradation
- Microtubule and mitosis dynamics
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Electrostatics and Colloid Interactions
- Polymer Surface Interaction Studies
- Protein Interaction Studies and Fluorescence Analysis
- Lattice Boltzmann Simulation Studies
- Anodic Oxide Films and Nanostructures
- Immune cells in cancer
- NMR spectroscopy and applications
- Electrochemical sensors and biosensors
Houston Methodist
2014-2024
Nanomed (Brazil)
2022
Methodist Hospital
2011-2017
Vilnius University
2007-2015
The University of Texas Health Science Center at Houston
2008-2011
The University of Texas MD Anderson Cancer Center
2010
The University of Texas at Austin
2010
Rice University
2010
University of Houston
2010
Vytautas Magnus University
2000-2006
Hollow gold nanoshells are more efficient in heat generation triggered by near infrared laser when they loaded into porous silicon particles, which results effective cancer-cell killing vitro and vivo. Collective electromagnetic coupling of nanoconfined hollow leads to dramatic enhancement thermal ablation.
The capillary wall is the chief barrier to tissue entry of therapeutic nanoparticles, thereby dictating their efficacy. Collagen fibers are an important component walls, affecting leakiness in healthy or tumor vasculature. Using a computational model along with vivo systems, we compared how collagen structure affects diffusion flux 1-nm chemotherapeutic molecule [doxorubicin (DOX)] and 80-nm chemotherapy-loaded pegylated liposome (DOX-PLD) We found direct correlation between content around...
This manuscript demonstrates a mechanically robust implantable nanofluidic membrane capable of tunable long-term zero-order release therapeutic agents in ranges relevant for clinical applications. The membrane, with nanochannels as small 5 nm, allows the independent control both dosage and mechanical strength through integration high-density short parallel to surface perpendicular micro- macrochannels interfacing ambient solutions. These membranes are created using precision silicon...
Functionalization of nanoparticles with cationic moieties, such as polyethyleneimine (PEI), enhances binding to the cell membrane; however, it also disrupts integrity cell's plasma and vesicular membranes, leading death. Primary fibroblasts were found display high surface affinity for iron oxide greater sensitivity than their immortalized counterparts. Treatment cells in presence incremental increases serum led a corresponding linear decrease The potential decreased linearly increased this...
Immune profiling of tissue through multiplex immunohistochemistry is important for the investigation immune cell dynamics, and it can contribute to disease prognosis evaluation treatment response in cancer patients. However, protocols mouse formalin-fixed, paraffin-embedded have been less successful. Given that formalin fixation paraffin embedding remains most common preparation method processing tissue, this has limited options study system impact novel therapeutics preclinical models. In...
Angiogenesis, a hallmark of cancer, is induced by vascular endothelial growth factor-A (hereafter VEGF). As result, anti-VEGF therapy commonly used for cancer treatment. Recent studies have found that VEGF expression also associated with immune suppression in patients cancer. This connection has been investigated preclinical and clinical evaluating the therapeutic effect combining antiangiogenic reagents therapy. However, mechanisms how strategies enhance are not fully understood. We others...
Transport theories based on the continuum hypothesis may not be appropriate at nanoscale in view of surface effects. We employed molecular dynamics simulations to study effects confinement and concentration diffusive transport glucose silica nanochannels (10 nm or smaller). found that modifies electrical properties that, below 5 channel height, adsorption diffusivity are significantly reduced. With increasing concentration, is reduced linearly bulk, while it nonlinearly interface. The...
Nanoparticles and their derivatives have engendered significant recent interest. Despite considerable advances in nanofluidic physics, control over nanoparticle diffusive transport, requisite for a host of innovative applications, has yet to be demonstrated. In this study, we performed diffusion experiments negatively positively charged fullerene (dendritic fullerene-1, DF-1, amino fullerene, AC60) 5.7 13 nm silicon nanochannels solutions with different ionic strengths. With demonstrated...
Time‐staggered combination chemotherapy strategies show immense potential in cell culture systems, but fail to successfully translate clinically due different routes of administration and disparate formulation parameters that preclude a specific order drug presentation. A novel platform consisting drug‐containing PLGA polymer nanoparticles, stably fashioned with shell composed complexed cationic cyclodextrin, capable releasing drugs time‐ sequence‐specifically within tumors is designed....
Controlling size, shape and uniformity of porous constructs remains a major focus the development materials. Over past two decades, we have seen significant developments in fabrication new, porous-ordered structures using wide range materials, resulting properties well beyond their traditional use. Porous materials been considered appealing, due to attractive such as pore size length, morphology surface chemistry. Furthermore, utilization within life sciences medicine has resulted...
Abstract We report an analysis of the mechanism human group IIA secretory phospholipase A 2 (sPLA ‐IIA) inhibition by natural anti‐inflammatory sesterterpene petrosaspongiolide M (PM). The amphiphilic PM, a γ‐hydroxybutenolide marine terpenoid, selectively reacts with sPLA ‐IIA Lys67 residue, located near enzyme–membrane interfacial binding surface, and covalently modifies enzyme through imine formation. Furthermore, PM is able to target active site several van der Waals/electrostatic...
The diffusivity of glucose was studied in confined environment a 10 nm silica nanochannel to evaluate the influence interface on transport at nano-scale range. Molecular dynamics studies revealed that forms weakly adsorbed layer interface. calculated diffusion coefficients were overestimated by up 30% compared experimental ones, though they follow same dependence concentration. Close interface, radial observed be lower than lateral, while diffusivities affected 3 from it. This slowdown is...
A hierarchical multiscale modeling approach, incorporating molecular dynamics and finite element techniques, is used to study parametrically diffusion regimes through nanoconfined fluid. Novel parameters that determine the character of regime kinetics within nanoscale confined fluids established by exploring where interface effects at solid surface are important. New transport characteristics when nanochannel confining dimension approaches 3--4 sizes diffusing molecules, which also marks...
Mass transport represents the most fundamental process in living organisms. It includes delivery of nutrients, oxygen, drugs, and other substances from vascular system to tissue waste products cells back lymphatic network organs. Furthermore, movement is achieved by mechanical forces generated muscles coordination with nervous system. The signals coming brain, which have character electrical waves, produce activation within muscle cells. Therefore, a physics perspective, there exist number...