A5064557092- Microfluidic and Capillary Electrophoresis Applications
- Nanopore and Nanochannel Transport Studies
- Electrospun Nanofibers in Biomedical Applications
- Microfluidic and Bio-sensing Technologies
- Tissue Engineering and Regenerative Medicine
- Histone Deacetylase Inhibitors Research
- Parkinson's Disease Mechanisms and Treatments
- Hormonal and reproductive studies
- Pharmacological Effects and Assays
- Nerve injury and regeneration
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Neurological disorders and treatments
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Sperm and Testicular Function
- Long-Term Effects of COVID-19
- Graphene and Nanomaterials Applications
- Membrane Separation Technologies
- Wound Healing and Treatments
- Mass Spectrometry Techniques and Applications
Cornell University
2021-2025
Weill Cornell Medicine
2022-2025
Yale University
2018-2019
NanoMedical Systems (United States)
2010-2015
This manuscript demonstrates a mechanically robust implantable nanofluidic membrane capable of tunable long-term zero-order release therapeutic agents in ranges relevant for clinical applications. The membrane, with nanochannels as small 5 nm, allows the independent control both dosage and mechanical strength through integration high-density short parallel to surface perpendicular micro- macrochannels interfacing ambient solutions. These membranes are created using precision silicon...
Aggregates of α-synuclein (αS) are hallmarks synucleinopathies, including Parkinson's Disease (PD) and Multiple System Atrophy (MSA). We have recently shown that αS lysine acetylation in the soluble monomer pool varies between healthy controls, PD, MSA patients. To study effects at all disease-relevant sites αS, we first compared production acetylated through either native chemical ligation or non-canonical amino acid (ncAA) mutagenesis. Since yields were comparable, ncAA mutagenesis was...
Hydrogels composed of solubilized decellularized extracellular matrix (ECM) are attractive materials because they combine the complexity native ECM with injectability and ease use. Nevertheless, these typically only tunable by altering concentration, which alters ligand landscape, or incorporating synthetic components, can result in an unfavorable host response. Herein, we demonstrate fabrication genetically ECM-derived materials, utilizing wild type (WT) (thrombospondin-2 knockout) TSP-2 KO...
Primary or secondary hypogonadism results in a range of signs and symptoms that compromise quality life requires life‐long testosterone replacement therapy. In this study, an implantable nanochannel system is investigated as alternative delivery strategy for the long‐term sustained constant release testosterone. vitro tests are performed using dissolution set up, with testosterone:2‐hydroxypropyl‐β‐cyclodextrin (TES:HPCD) 1:1 1:2 molar ratio complexes from quantify by HPLC. TES:HPCD complex...
The misfolding and aggregation of the protein α-synuclein (aSyn) into potentially neurotoxic oligomers is believed to play a pivotal role in neuropathogenesis Parkinson's disease (PD). Herein, we explore how apomorphine (Apo), nonselective dopamine D1 D2 receptor agonist utilized therapy for PD, affects toxicity aSyn vitro. Our data indicated that Apo inhibits fibrillation leading formation large oligomeric species (Apo-aSyn-O), which exhibit remarkable mesencephalic dopaminergic neurons...