A5068560180- Oral and Maxillofacial Pathology
- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- Bone Tumor Diagnosis and Treatments
- Axon Guidance and Neuronal Signaling
- dental development and anomalies
- Oral Health Pathology and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Oral and gingival health research
- Cancer, Hypoxia, and Metabolism
- Nonmelanoma Skin Cancer Studies
- Medicinal Plants and Bioactive Compounds
- Ear and Head Tumors
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Vascular Malformations and Hemangiomas
- Apelin-related biomedical research
- Neuroblastoma Research and Treatments
- Viral-associated cancers and disorders
- Parvovirus B19 Infection Studies
- Vascular Tumors and Angiosarcomas
- Tendon Structure and Treatment
- HIV/AIDS oral health manifestations
King Saud bin Abdulaziz University for Health Sciences
2021-2024
King Abdullah International Medical Research Center
2021-2024
National Guard Health Affairs
2023-2024
King Abdulaziz Medical City
2023-2024
King Fahd Medical City
2024
Boston Children's Museum
2020-2022
Boston Children's Hospital
2019-2022
Harvard University
2016-2022
Odontogenic tumors (OTs) are distinct conditions that develop in the jawbones, exhibiting diverse histopathological features and variable clinical behaviors. Unfortunately, literature on this subject Saudi Arabia remains sparse, indicating a pressing need for more comprehensive data concerning frequency, demographics, treatment modalities, outcomes of OTs. Objectives: The study aims to evaluate demographic features, treatment, OTs across three tertiary medical centers. Methods Material: OT...
Aims Primordial odontogenic tumour ( POT ) is a rare mixed neoplasm that composed of primitive ectomesenchyme resembling dental papilla, surfaced by epithelium inner enamel epithelium, without hard tissue formation. Most reported cases have presented in the posterior mandible as well‐demarcated radiolucency associated with an unerupted tooth first two decades life. The aim this report to describe clinicopathological features more . Methods and results Each asymptomatic well‐delineated...
Odontogenic cysts (OCs) are etiologically diverse conditions with a shared origin in the jaws. Unfortunately, there is scarcity of published data regarding OC frequency, treatment, and follow-up information Saudi Arabia, especially from tertiary centers. Objectives: The study aims to assess relative clinicopathological features, OCs three medical Methods Material: were identified King Abdulaziz Medical City, Fahad Prince Sultan Military City January 2010 December 2021. Results: Three hundred...
Abstract Background Warthin tumor (WT) is a common benign salivary of the parotid gland. Clinically, it occurs in men their fifth to seventh decades who typically smoke cigarettes. WTs have been reported with different head and neck neoplasms other gland tumors within same or another Kimura disease (KD) rare chronic inflammatory unknown etiology affecting young middle-aged Asian men. KD presents as an asymptomatic nodule area, regional lymphadenopathy involvement. Case presentation A...
Benign fibroosseous lesions (BFOLs) encompass a heterogenous collection of bone conditions characterized by replacing normal with fibro-collagenous tissue osteoid or woven bone, and cementicles. Despite their clinical significance, the frequency BFOLs in Saudi Arabia still needs to be assessed. This retrospective study investigated demographics Riyadh, Arabia, retrieving all cases recorded between January 1984 2013 from single Oral Pathology Laboratory archive. A total 64 were classified as...
Background and Objectives: Salivary gland tumors (SGTs) are diverse lesions with varying morphological clinical characteristics. Limited data exist on the distribution of SGTs in Saudi Arabia. We aimed to fill this gap by examining across four tertiary hospitals Riyadh. Materials Methods: A retrospective analysis was conducted SGT cases diagnosed from January 2010 December 2022 investigate clinicopathological features (tumor location, patient sex, age). Histological slides were evaluated two...
The lymphatic system is essential in mediating tissue fluid balance. Lymphatic diseases including lymphedema occur as a result of dysfunctional networks and are significant public health issue with no known cure. Our long‐term goal to understand the cellular molecular processes that control function order better treat diseases. Some primary patients have mutations neuropilin‐2 gene ( NRP2 ). transmembrane receptor found endothelial cells (LEC) unique its ability transmit both...
The Semaphorin‐3F ( Sema3F ) gene was originally isolated from chromosome 3p21 in a region commonly deleted small cell lung cancer and subsequently shown to act as tumor suppressor. is expressed epithelial cells ligand of the Neuropilin‐2 (Nrp2) receptor. We have previously that normal lack Nrp2, but upregulate this receptor during dysplastic stage carcinogenesis. Nearly all cancers oral cavity are squamous carcinomas (OSCC) which highly express Nrp2. Preclinical trials performed our...
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The majority of oral malignancies (90%) are squamous cell carcinoma (OSCC), and two‐thirds OSCC patients present at diagnosis with disseminated disease. can develop from pre‐cancerous lesions known as dysplasia. Early detection these leads to better management outcome. We investigated the role Neuropilin‐2 (NRP2) surface receptor in dysplasia OSCC. NRP2 is regarded an important mediator angiogenesis lymphangiogenesis, but its epithelial cells less understood. bind VEGFA a complex VEGFR2 or...
Oral squamous cell carcinoma (OSCC) accounts for the majority of all oral malignancies. The overall survival rate patients diagnosed with advanced‐stage OSCC (with metastasis) is only 39%, and prognosis these has not improved dramatically despite advances in chemotherapeutic, radiotherapeutic, surgical protocols. As such, there remains an urgent need to develop new therapies improve outcome. Recently, our laboratory identified Neuropilin‐2 (NRP2) transmembrane receptor as a novel target its...
Testing novel anti‐cancer drugs requires preclinical cancer trials, often performed in mice. The host tumor microenvironment (TME), defined as the cells surrounding or infiltrating such stromal and immune well their secreted proteome, may affect tumorigenicity progression. Most experimental models are cutaneously. skin is largest organ body undergoes morphological cellular changes during each phase of hair cycle: anagen (growth), catagen (regression), telogen (resting). rodent cycle differs...
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide. The majority (67%) of patients with this aggressive already exhibit local or distant metastases at time initial diagnosis. Understanding molecular mechanisms that regulate OSCC progression and metastasis paramount to developing novel therapeutic strategies for disease. Enhanced tumor‐associated lymphangiogenesis correlates increased lymph node adversely affects prognosis in OSCC. Neuropilin 2 (NRP2) an endothelial...
Dysfunctional lymphatic networks can lead to diseases such as lymphedema well aggravate cardiovascular atherosclerosis and hypertension. Some primary patients have mutations in the Neuropilin 2 ( NRP2 ) gene, which encodes a transmembrane receptor that acts with VEGFR3 for ligands VEGF-C VEGF-D. Nrp2 has been shown be key regulator of vessel development neonate global -deficient mice suffer from reduced density. However, protein expression is dramatically downregulated after birth its role...