A5071924167- Sex work and related issues
- Reproductive tract infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Traditional Chinese Medicine Studies
- interferon and immune responses
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Sexual function and dysfunction studies
- Ultrasound and Hyperthermia Applications
- Pelvic floor disorders treatments
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Cancer-related molecular mechanisms research
- Ultrasound Imaging and Elastography
- Sirtuins and Resveratrol in Medicine
- Advanced biosensing and bioanalysis techniques
- Nursing Diagnosis and Documentation
- Hydrogen's biological and therapeutic effects
Zhongda Hospital Southeast University
2013-2024
Wenzhou Medical University
2024
The Central Hospital of Shaoyang
2015-2024
Guangzhou University of Chinese Medicine
2018-2021
Southeast University
2013-2021
Shanghai Jiao Tong University
2012-2021
Shanghai Institute of Hematology
2020
Shanghai Mental Health Center
2012
Changsha University
2011
Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading frames (sORFs), but the coding capacities of these sORFs and functions resulting micropeptides remain elusive. Here, we report that human lncRNA MIR155HG encodes a 17-amino acid micropeptide, which termed miPEP155 (P155). is highly expressed by inflamed antigen-presenting cells, leading to discovery P155 interacts with adenosine 5'-triphosphate binding domain heat shock cognate protein 70 (HSC70), chaperone...
Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1–3 and individuals COVID-19 have symptoms that can be asymptomatic, mild, moderate or severe4,5. In the early phase of infection, T- B-cell counts are substantially decreased6,7; however, IgM8–11 IgG12–14 detectable within 14 d after symptom onset. COVID-19-convalescent individuals, spike-specific neutralizing antibodies variable3,15,16. No specific drug vaccine...
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Some evidence suggests that dysbiosis gut microbiota could be associated with PCOS clinical parameters, but little known for association between vaginal microbiome and PCOS.To determine differences healthy control women.In this case-control study, newly diagnosed (n = 39) controls 40) were included from hospital maternal child health centre, respectively. The swabs collected, structures...
Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious that has spread worldwide. Methods: This was a retrospective case series involving 218 patients admitted to three tertiary hospitals in the Loudi, Shaoyang, and Xiangtan areas of China from January 21 June 27, 2020, who were confirmed by RT-PCR have SARS-CoV-2 infection. The patients' clinical characteristics, laboratory results, treatments, prognoses based on classification recorded. Poor outcome defined as admission...
Abstract Background Azvudine has clinical benefits and acceptable safety against COVID-19, including in patients with comorbidities, but there is a lack of available data for its use older adult patients. This study explored the effectiveness azvudine adults mild or moderate COVID-19. Methods retrospective cohort included aged ≥80 diagnosed COVID-19 at Central Hospital Shaoyang between October November 2022. According to therapies they received, eligible were divided into azvudine,...
Previous studies suggest that the vaginal microbiome is associated with polycystic ovary syndrome (PCOS). However, clinical manifestations of PCOS are heterogeneous. Whether related different symptoms was unknown.
Melanoma is a life-threatening cancer with limited treatments. Retinoic acid-inducible gene I (RIG-I) cytosolic pattern recognition receptor (PRR) crucial to RNA virus sensing, interferon production, and tumor suppression. Quercetin, natural flavonoid, has particularly therapeutic interests prevent treat cancer, for its pharmacological effects against oxidant, inflammation, angiogenesis. Quercetin was investigated anti-melanoma activity potential mechanisms in this study. We found that...
The application of serum biomarker to ovarian tumors for early stage detection and clinical diagnosis is a rapidly expanding research area. problem with conventional markers that they are often released too late or at low level be detected in time trigger effective treatment. Ultrasound has been used influence bio-effects living cells, but there only one reported case the use ultrasound enhance release (Carcinoembryonic antigen CEA). In this study we report combination cancer biomarkers...
Abstract Background Insulin resistance (IR) induces hyperinsulinemia, which activates downstream signaling pathways such as the phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathway, ultimately leading to abnormal proliferation and apoptosis of endometrial cells. This is thought be a key pathogenic mechanism underlying development polyps (EP). study aims investigate relationship between IR EP, expression levels molecules, including PI3K AKT, related laboratory parameters were...
SHR-1222, a novel humanized monoclonal antibody targeting sclerostin, has been shown to induce bone formation and decrease resorption at single dose ranging 50–400 mg in our previous phase 1 trial. This study was randomized, double-blind, placebo-controlled, dose-escalation trial, which further investigated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity of multiple ascending doses SHR-1222 women with postmenopausal osteoporosis (POP). A total 105 POP...
The purpose of the study was to form a questionnaire expert consensus about phlegm turbidity syndrome coronary heart disease (CHD) using literature method and Delphi method, which could provide objective evidences for clinical diagnosis treatment CHD.The CBM, CNKI, VIP, PubMed were searched. articles CHD with definite related four diagnostic data included. Based on results two rounds conducted. TCM experts enrolled. Concentration coordination index used select items.Literature method: A...
In this manuscript we constructed a dual-responsive nano-drug delivery system for matrix metalloproteinases and ATP in ovarian cancer microenvironment. The nanomicelle PCL-DNA/DOX-Peptide-PEG was prepared by intercalating doxorubicin hydrochloride between C G base pairs of DNA double helix structure. Another ATP-responsive PCL-DNA/DOX-PEG prepared. Then analyzed the characterization nanomicelles (particle size, potential, surface morphology, etc.) drug loading binding release behavior....
Urinary Incontinence was acknowledged in 1998 by World Health Organization as a disease, to raise the awareness of condition . Literature suggests that 50% incontinent women would be less than 50 years age. Despite great evolution area gynecology, incontinence remains real problem for number around world. In some embarrassing nature urinary has lead hide existence syndromes. Most will seek health care at late stage, when there is little or nothing do. Alternative opportunity surgery reveal...
Female sex workers (FSWs) are key groups in the transmission of sexual transmitted infections (STI), and vaginal microbiome variations play an important role transmission. We aimed to explore characteristics among FSWs. A total 24 cross-border FSWs were randomly selected from a cross-sectional survey for female southwest China. Thirty-seven non-sex (FNSWs) gynecology clinic health examination center. Vaginal swabs collected, bacterial DNA extracted 16S rRNA genes sequenced. Differences...
Background . The aim was to develop a diagnostic questionnaire for damp phlegm pattern and blood stasis in coronary heart disease patients (CHD-DPBSPQ). Methods standard procedures of development were carried out assess CHD-DPBSPQ. assessed using the CHD-DPBSPQ, CHD-DPPQ, CHD-BSPQ. Four methods used select items on CHD-DPBSPQ pilot study based data from Guizhou tertiary grade A hospital. Cronbach’s alpha split-half reliability, test-retest content validity, criterion construct convergent...
Summary Seroconversion appeared early after COVID-19 onset, and convalescent sera therapy benefit some critical patients. However, neutralizing antibody (nAb) in convalescents is largely unknown. We found that 97.01% (65/67) of maintained IgG antibodies with high binding avidity to SARS-CoV-2 spike subunits S1 S2, 95.52% (64/67) had neutralization activity against pesudovirus, one month discharge (median ID 50 , 2.75; IQR, 2.34-3.08). Some exhibited cross-neutralization SARS-CoV (76.12%),...
IL-17-secreting Th17 cells play an important role in the pathogenesis of various inflammatory and autoimmune diseases. IL-17-targeted biologics small molecules are becoming promising treatments for these In this study, we report that SZB120, a derivative natural compound 3-acetyl-β-boswellic acid, inhibits murine cell differentiation by interacting with α-subunit eukaryotic initiation factor 2 (eIF2α). We showed SZB120 directly interacts eIF2α contributes to serine 51 phosphorylation eIF2α....