A5057106452- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Education
- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Retinal Development and Disorders
- Mobile Health and mHealth Applications
- Computational Drug Discovery Methods
- Urban Green Space and Health
- Adenosine and Purinergic Signaling
- Bone health and osteoporosis research
- RNA modifications and cancer
- Noise Effects and Management
- Physical Activity and Health
- Bone health and treatments
- Autophagy in Disease and Therapy
- Wildlife-Road Interactions and Conservation
- Adolescent and Pediatric Healthcare
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
Fujian Medical University
2025
Second Xiangya Hospital of Central South University
2016-2025
Central South University
2009-2025
Taiyuan University of Technology
2025
National Institute of Biological Sciences, Beijing
2009-2025
University of Waterloo
2024-2025
Nanjing Sport Institute
2025
City University of Hong Kong
2025
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2014-2024
Diabetes poses heavy social and economic burdens worldwide. management apps show great potential for diabetes self-management. However, the adoption of by patients is poor. The factors influencing patients' intention to use these are unclear. Understanding behavioral necessary support development promotion app use.This study aimed identify determinants based on an integrated theoretical model.The hypotheses our research model were developed extended Unified Theory Acceptance Use Technology...
The diabetes disease burden in China is heavy, and mobile apps have a great potential for management. However, there lack of investigation app use among Chinese patients diabetologists. perspectives attitudes diabetologists regarding are also unclear.Our objectives were to investigate patients' diabetologists' use, attitudes, perspectives, as well needs, with respect provide information the optimal design best strategies promote their use.Diabetes across surveyed on WeChat (Tencent Corp)...
The spike protein of SARS-CoV-2 has been a promising target for developing vaccines and therapeutics due to its crucial role in the viral entry process. Previously reported cryogenic electron microscopy (cryo-EM) structures have revealed that free fatty acids (FFA) bind with protein, stabilizing closed conformation reducing interaction host cell vitro. Inspired by these, we utilized structure-based virtual screening approach against conserved FFA-binding pocket identify small molecule...
Major depressive disorder (MDD) is a common complication of diabetes and often observed alongside diabetic neuropathic pain (DNP) as comorbidity in patients. Long non-coding RNA (lncRNA) plays an important role various pathophysiological processes. The P2X7 receptor responsible for triggering inflammatory responses, such pyroptosis, linked to depression. aim this study was investigate the effect lncRNA MSTRG.81401 on hippocampal pyroptosis induced by rats with DNP combined MDD (DNP + MDD)....
Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling. Increasing evidence indicates that endothelial-to-mesenchymal transition (EndMT) in artery endothelial cells (PAECs) pivotal trigger initiating this However, the regulatory mechanisms underlying EndMT PH are still not fully understood.
During programmed cell death, apoptotic cells are recognized and rapidly engulfed by phagocytes. Although a number of genes have been identified that promote corpse engulfment, it is not well understood how phagocytosis negatively regulated. Here we Caenorhabditis elegans myotubularin MTM-1 as negative regulator engulfment. Myotubularins (MTMs) constitute large, highly conserved family lipid phosphatases. MTM gene mutations associated with various human diseases, but the cellular functions...
The rational design of selective kinase inhibitors remains a great challenge. Here we describe physics-based approach to computationally modeling the inhibitor selectivity profile. We retrospectively assessed this protocol by computing binding profiles 17 well-known against 143 kinases. Next, predicted profile chemotherapy drug mitoxantrone, and chose top five targets for in vitro assays. Remarkably, mitoxantrone was shown possess low nanomolar inhibitory activity PIM1 inhibit PIM1-mediated...
Previous studies have demonstrated that activation of P2X7 receptors (P2X7R) results in the proliferation and migration some types tumor. Here, we asked whether how activated P2X7R contribute to human glioma cells. Results showed number positive cells was increasing with grade In U87 U251 cell lines, both expressed expression enhanced by 3'-O-(4-benzoylbenzoyl) ATP (BzATP), agonist P2X7R, siRNA. Our also 10 μM BzATP sufficient induce significantly, while reached peak 100 BzATP. Also,...
The conformation of a series zero-generation polyamidoamine dendrimers end-labeled with four 1-pyrene-butyroyl, -hexanoyl, -octanoyl, -decanoyl, and -dodecanoyl derivatives, referred to as the PyCX-PAMAM-G0 samples X = 4, 6, 8, 10, 12, respectively, was characterized in N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), aqueous solutions 50 mM sodium dodecyl sulfate (SDS) or dodecyltrimethylammonium bromide (DTAB). determined from global model-free analysis (MFA) fluorescence decays,...
Accurate building segmentation has become critical in various fields such as urban management, planning, mapping, and navigation. With the increasing diversity number, size, shape of buildings, convolutional neural networks have been used to segment extract buildings from images, resulting increased efficiency utilization image features. We propose a semantic method improve traditional Unet network by integrating attention mechanism boundary detection. The module combines channel spatial...
Objective The aim was to summarise the prenatal ultrasound characteristics, associated anomalies and pregnancy outcomes of fetal right aortic arch (RAA) discuss value diagnosis prognostic analysis. Methods We retrospectively analysed 157 cases RAA diagnosed via in our hospital from October 2017 2022. features were characterised by comparing data with anatomical casting results after termination or postnatal imaging surgical intervention analyse prognosis misdiagnoses RAA. Results Of cases,...
The hemoglobin glycation index (HGI) represents the discrepancy between glucose management indicator (GMI) based on mean blood levels and laboratory values of glycated (HbA1c). HGI is a promising for identifying individuals with excessive glycosylation, facilitating personalized evaluation prediction diabetic complications. However, factors influencing in patients type 1 diabetes (T1D) remain unclear. Autoimmune destruction pancreatic β cells central T1D pathogenesis, yet insulin resistance...
TBK1 is a crucial kinase involved in immunity, inflammation, and autophagy with dysregulation linked to various diseases, making it potential therapeutic target. In this study, we applied structure-based lead optimization approach design potent selective inhibitors. A focused virtual library containing over 5,000 compounds was constructed, sampled, refined within the binding site, followed by 10 ns molecular dynamics simulation for each modeled complex. Based on MM/PBSA free energies...
<title>Abstract</title> The REGULATION (EU) 2023/1542 OF THE EUROPEAN PARLIAMENT AND COUNCIL of 12 July 2023 (short as “EU Batteries Regulation”) presents both a challenge and an opportunity for battery manufacturers operators they must not only navigate market competition changes but also comply with new regulatory requirements. However, this to stimulate the growth industry foster sustainable development electric vehicle sector. This paper is one first attempts develop life cycle–based...
Genotoxic drug resistance is one of the major obstacles for cancer treatment. Our previous study demonstrates that cold shock domain containing E1 (CSDE1) associated with resistance. In this study, we aim to demonstrate CSDE1 regulates cellular response genotoxic drugs and investigate its mechanism action in Tissues blood samples from patients were used evaluate relationship between response. Comet immunofluorescence assays conducted role DNA damage repair. Systematic knockout mouse models...