A5083402816- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Hepatitis B Virus Studies
- Inflammatory Bowel Disease
- Intraperitoneal and Appendiceal Malignancies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Genetic factors in colorectal cancer
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- Milk Quality and Mastitis in Dairy Cows
- Peptidase Inhibition and Analysis
- Appendicitis Diagnosis and Management
- Biosensors and Analytical Detection
- Liver Disease and Transplantation
- Listeria monocytogenes in Food Safety
- Advanced Nanomaterials in Catalysis
- Reproductive Physiology in Livestock
- Intestinal and Peritoneal Adhesions
- Genetic and phenotypic traits in livestock
- Ovarian cancer diagnosis and treatment
- Cardiac Structural Anomalies and Repair
- Marine animal studies overview
- Biomedical Ethics and Regulation
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2024
Sun Yat-sen University
2017-2024
Key Laboratory of Guangdong Province
2023
Nanjing Drum Tower Hospital
2022
Southeast University
2022
Chinese University of Hong Kong
2019-2022
Sun Yat-sen University Cancer Center
2017-2018
State Key Laboratory of Oncology in South China
2017
Yonsei University
2015
Heilongjiang Bayi Agricultural University
2011-2014
Proteus spp, Gram-negative facultative anaerobic bacilli, have recently been associated with Crohn's disease (CD) recurrence after intestinal resection. We investigated the genomic and functional role of as a gut pathogen in CD.Proteus spp abundance was assessed by ure gene-specific polymerase chain 54 pairs fecal samples 101 biopsies from patients CD healthy controls. The adherence, invasion, intracellular presence 2 distinct isolates mirabilis epithelial cells were evaluated using...
Abstract Manipulation of gut microbiota by bacterial metabolites has shown protective effects against colitis; while the efficacy is strictly limited poor oral delivery efficiency and single drug usage. Here, a novel prebiotics postbiotics synergistic microcapsule composed indole‐3‐propionic acid (IPA) postbiotic three including alginate sodium, resistant starch (RS), chitosan via microfluidic electrospray for preventing treating colitis are proposed. It found that administration IPA...
Developing advanced biocompatibility materials is of critical importance in biomedical engineering. Polyhydroxyalkanoates (PHA), being famous for its flexible mechanical properties, thermal biocompatibility, and biodegradability, has been widely used wound dressings, artificial blood vessels, heart valves, nerve conduits, bone cartilage scaffolds, surgical sutures, other fields. However, reports on the application PHA tissue repair regeneration are often lacking systematics. Here, a...
The aim of this study was to inactivation different pathogenic bacteria on agar model surface using TiO2-UV photocatalysis (TUVP).A unified food simulated Bacto(™) agar, a routinely used microbial medium. foodborne Escherichia coli K12 (as surrogate for E. O157:H7), Salmonella Typhimurium, Staphylococcus aureus and Listeria monocytogenes were inoculated onto the surface, followed by investigation TUVP-assisted morphological changes in bacterial cells. TUVP process showed higher inactivation,...
The primary objective of this study is to develop a prediction model for peritoneal metastasis (PM) in colorectal cancer by integrating the genomic features cancer, along with clinicopathological features. Concurrently, we aim identify potential target implicated dissemination through bioinformatics exploration and experimental validation. By analyzing landscape from 363 metastatic patients, identified 22 differently distributed variables, which were used subsequent LASSO regression...
For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify survival benefits safety of versus TACE HCC MaVI. The PubMed, Cochrane Library Web Science databases were searched for eligible studies. There no prospective studies identified. 8...
Abstract Ventral hernia is a public health issue and millions of meshes are used to repair abdominal wall defects every year. Polypropylene‐based composite represent an important class materials for intraperitoneal repair, but the generally give rise infection, seroma, migration, adhesion, leading severe consequence or even reoperation. Here, facile versatile one‐way fabrication lightweight, highly permeable, biocompatible with superior antiadhesion properties proposed by modifying...
The aim of this study was to investigate the effects low-level laser therapy (LLLT) on a rat model lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms. induced by inoculation LPS through canals mammary gland. results showed that LPS-induced secretion IL-1β IL-8 significantly decreased after LLLT (650 nm, 2.5 mW, 30 mW/cm2). also inhibited intercellular adhesion molecule-1 (ICAM-1) expression attenuated decrease CD62L increase CD11b. Moreover, suppressed...
Fluid and electrolyte disturbance, which impairs renal function, has been reported in patients with temporary ileostomy. However, the dynamic changes serum electrolytes function rectal cancer ileostomy have not well described. In present study, we aimed to evaluate alterations undergoing creation closure.The levels of potassium, sodium, blood urea nitrogen, creatinine estimated glomerular filtration rate (eGFR) were analyzed 320 including 156 an (the group) 164 without control group).After...
Purpose The prognostic value of desmoplastic reaction (DR) has not been investigated in colorectal cancer (CRC) patients with synchronous peritoneal metastasis (SPM). present study aimed to identify whether DR can predict overall survival (OS) and develop a novel nomogram. Methods CRC SPM were enrolled from single center between July 2007 2019. patterns primary tumors classified as mature, intermediate, or immature according the existence absence keloid-like collagen myxoid stroma. Cox...
To study the liver histopathological features that are distinctive between chronic hepatitis B virus (HBV) infection patients who have normal serum alanine aminotransferase (ALT)/asparatate (AST) and those with mildly elevated ALT/AST. One-hundred-and-thrity-four HBV ALT/AST 165 were included in study. Liver biopsies performed used to assess histological changes by hematoxylin-eosin reticular fiber staining; mild severe scoring for inflammation was made as grade G0-G4 fibrosis stage S0-S4....
Although hepatitis B virus (HBV) is still one of the most common etiological factors for hepatocellular carcinoma (HCC), association between HBV mutations and clinical characteristics prognosis HBV-related HCC patients (HBV-HCC) after surgical resection remains largely unknown.A cohort 131 consecutive who received hepatectomy HBV-HCC were retrospectively enrolled. The genotype 14 genomic mutations, which have been reported to relate in liver samples, sequenced. associations outcomes...
<h3>Background</h3> Obesity is associated with altered gut microbiota. Archaeome an important part in intestinal microbiota, however, the role of archaea obesity remains unknown. We aimed to delineate alterations subjects and explore effect bariatric surgery-associated weight loss intervention modulating archaeal composition. <h3>Methods</h3> A total 231 obese 184 lean controls shotgun metagenomic sequencing available were retracted from three public cohorts. Of which, 23 undergone surgery...
Abstract Background Colorectal cancer is the third-most common type of cancer. When peritoneal metastasis (PM) develops, diagnosing metastatic lesions difficult and prognosis poor. This study aimed to compare value fluorine-18 fibroblast activation protein-specific inhibitor (18F-FAPI-42) fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting PM colorectal guide clinical decision-making. Methods Forty-eight patients with who underwent both...
Adherent invasive Escherichia Coli (AIEC) invades gut epithelium and colonise the mucosa of patients with Crohn’s disease (CD). Despite increasing use faecal microbiota transplantation (FMT) to treat inflammatory bowel (IBD), mechanisms factors affecting treatment outcome is unclear. This study aims assess whether AIEC affects efficacy FMT explore underlying success. C57BL/6 wild-type mice were colonised an strain (AIEC62d; 109 CFU) recently isolated from a patient in Hong Kong or...
<h3>Background</h3> Adherent-invasive <i>Escherichia Coli</i> (AIEC) colonizes mucosa of patients with Crohn's disease (CD). Fecal microbiota transplantation (FMT) has been reported to be effective in treating CD but the response rates are variable. We investigated prevalence AIEC Chinese population and explored impact on FMT efficacy. <h3>Methods</h3> strains were isolated from ileal tissues (n=64) healthy subjects (n=53) by selection culture protection assay Intestine-407 cell lines their...