A5100650392- Pneumonia and Respiratory Infections
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gastrointestinal motility and disorders
- Antibiotic Use and Resistance
- Bacterial Infections and Vaccines
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- Acupuncture Treatment Research Studies
- Patient-Provider Communication in Healthcare
- Functional Equations Stability Results
- Bacterial biofilms and quorum sensing
- Diagnosis and treatment of tuberculosis
- Spinal Fractures and Fixation Techniques
- Mathematical and Theoretical Analysis
- Healthcare Systems and Reforms
- Urinary Bladder and Prostate Research
- Natural Antidiabetic Agents Studies
- HIV/AIDS Research and Interventions
- Antimicrobial Resistance in Staphylococcus
- Curcumin's Biomedical Applications
- Sex work and related issues
- Nonlinear Differential Equations Analysis
- Sirtuins and Resveratrol in Medicine
Nanjing Medical University
2025
Nantong University
2025
Taizhou People's Hospital
2025
Army Medical University
2022-2025
Anhui Medical University
2022-2023
Southeast University
2023
Guangxi Zhuang Autonomous Region Brain Hospital
2013-2020
Heze Municipal Hospital
2019
Linyi University
2011
Beijing Center for Disease Prevention and Control
2008
Objective The aim of this study was to investigate inequalities in primary healthcare visits by using the Gini coefficients (GPVs) as derived from large-scale and region-wide electronic records explore estimation utility GPV. Design used a cross-sectional design. It first extracted random sample 7.09 million care 1 October 2019 31 December 2021. Then it developed logarithmic models GPVs different months performed descriptive generalised linear mixed-effects regression analyses for all-cause...
Parenteral subunit vaccines typically elicit systemic humoral immune responses but often struggle to induce mucosal immunity. Herein, we developed a promising adjuvant system, TB/P2C-NE, tamibarotene-loaded nanoemulsion incorporating the TLR2/6 agonist Pam2CSK4. Upon intramuscular vaccination, TB/P2C-NE promoted antigen-specific in gastrointestinal tract, accompanied by and cellular response. Mechanistically, tamibarotene upregulated intestinal homing molecule CCR9 on lymphocytes through...
As TLR2 agonists, several lipopeptides had been proved to be candidate vaccine adjuvants. In our previous study, mimicking N-terminal structures of the bacterial lipoproteins were also able promote antigen-specific immune response. However, structure-activity relationship as agonists is still unclear. Here, 23 synthetic with same lipid moiety but different peptide sequences synthesized, and their activities in vitro mucosal adjuvant effects OVA evaluated. LP1-14, LP1-30, LP1-34 LP2-2...
Abstract Background Long non‐coding RNA (lncRNA) small nucleolar host gene 17 (SNHG17) is a carcinogenic lncRNA in diverse cancers. The expression pattern and mechanisms of SNHG17 glioma still await verification. Methods Paired samples were enrolled. SNHG17, miR‐23b‐3p, zinc‐fingers homeoboxes 1 (ZHX1) mRNA examined by quantitative real‐time polymerase chain reaction (qRT‐PCR). short hairpin (shRNA) miR‐23b‐3p mimics transfected into LN229 U251 cell lines to repress up‐regulate expression,...
Two new oleanane triterpene glycosides were isolated from the n-BuOH extract of Gymnema inodorum. On basis spectroscopic evidences, their structures elucidated as 2α, 3β-dihydroxy-olean-12-ene-23, 28-dioic acid-3-O-β-D-glucopyrano-side and 3β, 15β-trihydroxy-olean-12-ene-23, acid-3-O-β-D-gluco-pyranoside.
In the past 10-15 years, government of China has made various efforts in tackling excessive antibiotics use. Yet, little is known about their effects at rural primary care settings. This study aimed to determine impact policies and COVID-19 pandemic on antibiotic prescribing practices such settings utilizing data from separate studies carried out pre- during pandemic, 2016 2021 Anhui province, China, using identical sampling survey approaches. Data prescribed, diagnosis, socio-demographic,...
Gastrointestinal symptoms (GISs) are caused by a combination of biopsychosocial factors and highly prevalent worldwide. Given their complex nature, coupled with ineffective communication diagnoses physicians, patients intimate GISs often feel stigmatized. This, in turn, can inhibit ability to express thoughts feelings adequately, leading them over- or underreport symptoms. Moreover, selective service-seeking for reporting have direct bearing on the stage disease at presentation and,...
Cationic nanostructures have emerged as an adjuvant and antigen delivery system that enhances dendritic cell maturation, ROS generation, uptake then promotes antigen-specific immune responses. In recent years, retinoic acid (RA) has received increasing attention due to its effect in activating the mucosal response; however, order use RA a adjuvant, it is necessary solve problem of dissolution, loading, delivery. Here, we describe cationic nanoemulsion-encapsulated (CNE-RA) composed lipid...
In this paper, we describe sex-related health risks among hostesses in two metropolises China based on data obtained from in-depth interviews. The show that hostesses, many engaging commercial sex, are vulnerable to HIV infection, unwanted pregnancies and reproductive tract infections. Nevertheless, obstacles still present hinder them safe sex. findings our study illustrate the need for targeted interventions order improve promote sex group.
Biomimetic nanoparticles obtained from bacteria or viruses have attracted substantial interest in vaccine research and development. Outer membrane vesicles (OMVs) are mainly secreted by gram-negative during average growth, with a nano-sized diameter self-adjuvant activity, which may be ideal for delivery. OMVs functioned as multifaceted delivery system proteins, nucleic acids, small molecules. To take full advantage of the biological characteristics OMVs, bioengineered Escherichia...
Biomimetic nanoparticles obtained from bacteria or viruses have attracted substantial interest in vaccine research and development. Outer membrane vesicles (OMVs) are mainly secreted by gram-negative during average growth, with a nano-sized diameter self-adjuvant activity, which may be ideal for delivery. OMVs functioned as multifaceted delivery system proteins, nucleic acids, small molecules. To take full advantage of the biological characteristics OMVs, bioengineered Escherichia...
The way to distinguish convergence or divergence of an infinite integral on non-negative continuous function is the important and difficult question in mathematical teaching all time. Using comparison integrands judge some exceptional integrals are hard even useless. In this paper, we establish exponential integrating factor negative function, present a new method test based its factor. These conclusions convenient valid additions previously known results.
Abstract Background To design a personalized dietary intervention package for hypertensive patients (PDIPH) and to assess its impact on the patient’s blood pressure knowledge-attitude-practice (KAP) score. Methods A randomized controlled trial of 3,005 from JieShou City were recruited used iFLYTEK intelligent voice sphygmomanometer. After excluding unqualified patients, there 1,190 1,202 randomly divided into control groups respectively. Patients in group received same health care as group,...
Abstract Background Antibiotics are over-used for patients with respiratory tract infections (RTIs) in primary care, especially the rural areas of China. Methods A cluster randomized controlled trial (RCT) will be carried out to estimate effectiveness a tailored message package educating reduce antibiotic use symptomatic (RTIs). In intervention group, receive 12 short messages consecutive days. The whole process design, modification, translation (of substitution variables), and sending...
Home blood pressure telemonitoring (HBPT) is witnessing rapid diffusion worldwide. Contemporary studies documented mainly short-term (6-12 months) effects of HBPT, and there are limited data about its uptake.The aim this study was to explore the 3-year use determinants interactions with systolic diastolic (SBP/DBP) overall (BP) control rate.HBPT records were obtained from a cohort 5658 patients hypertension in Jieshou, Anhui, China, structured household survey random sample (n=3005) cohort....
<sec> <title>BACKGROUND</title> Gastrointestinal symptoms (GISs) are caused by a combination of biopsychosocial factors and highly prevalent worldwide. Given their complex nature, coupled with ineffective communication diagnoses physicians, patients intimate GISs often feel stigmatized. This, in turn, can inhibit ability to express thoughts feelings adequately, leading them over- or underreport symptoms. Moreover, selective service-seeking for reporting have direct bearing on the stage...