A5014572717- Cardiac pacing and defibrillation studies
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Metabolism and Genetic Disorders
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Diet and metabolism studies
- Immune Response and Inflammation
- Immune responses and vaccinations
- Advanced Glycation End Products research
- Cardiovascular Function and Risk Factors
- Mesenchymal stem cell research
- Alcoholism and Thiamine Deficiency
- Salivary Gland Disorders and Functions
- Inflammasome and immune disorders
- interferon and immune responses
- Circadian rhythm and melatonin
- Antifungal resistance and susceptibility
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Hepatobiliary Diseases and Treatments
- Neurological Disorders and Treatments
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- Nephrotoxicity and Medicinal Plants
- Glaucoma and retinal disorders
Punan Hospital
2024-2025
Children's Hospital of Fudan University
2024
Chongqing Cancer Hospital
2024
Chongqing University
2024
Harvard University
2020-2023
Ultragenyx Pharmaceutical (United States)
2020-2023
Massachusetts General Hospital
2023
Mass General Brigham
2023
Tianjin Medical University
2016-2022
Tianjin Medical University Eye Hospital
2016-2022
Endoscopic ultrasound-guided biliary drainage using electrocautery-enhanced (ECE) delivery of lumen-apposing metal stent (LAMS) is gradually being recognized as a viable palliative technique for malignant obstruction after endoscopic retrograde cholangiopancreatography (ERCP) failure. However, most the studies that have assessed its efficacy and safety were small heterogeneous. Prior meta-analyses six or fewer published 2 years ago therefore underpowered to yield convincing evidence.
Posaconazole (PCZ), approved for prophylaxis against invasive fungal disease in high-risk patients, is commercially available orally as a suspension formulation (PCZ-susp) and delayed-release tablet (PCZ-tab). We evaluated the serum steady-state concentrations (Css) of PCZ stratified by administered antifungal patients with myeloid malignancies (n = 150). The primary outcome was attainment rate target Css ≥700 ng/ml. Secondary outcomes included toxicity assessment (hepatotoxicity corrected...
Purpose. This study aims to evaluate dry eye and ocular surface conditions of myopic teenagers by using questionnaire clinical examinations. Methods. A total 496 eyes from 248 (7-18 years old) were studied. We administered Ocular Surface Disease Index (OSDI) questionnaire, slit-lamp examination, Keratograph 5M. The patients divided into 2 groups based on OSDI standard, their surfaces meibomian gland evaluated. Results. tear meniscus heights the normal in range. Corneal fluorescein scores...
Abstract Long‐chain fatty acid oxidation disorders (LC‐FAOD) are autosomal recessive conditions that impair conversion of long‐chain acids into energy, leading to significant clinical symptoms. Triheptanoin is a highly purified, 7‐carbon chain triglyceride approved in the United States as source calories and for treatment pediatric adult patients with molecularly confirmed LC‐FAOD. CL202 an open‐label, long‐term extension study evaluating triheptanoin (Dojolvi) safety efficacy Patients...
Rationale: Corneal transplantation is an effective treatment to corneal blindness. However, the immune rejection imperils allograft survival. An interventional modality urgently needed inhibit and promote In our previous study, subconjunctival injections of bone marrow-derived mesenchymal stem cells (BM-MSCs) into a rat model extended survival for 2 d. this we sought generate IL-10-overexpressing BM-MSCs, aiming boost survival-promoting effects BM-MSCs on allografts explore molecular...
Long-chain fatty acid oxidation disorders (LC-FAODs) result in life-threatening energy metabolism deficiencies/energy source depletion. Triheptanoin is an odd-carbon, medium chain triglyceride (that anaplerotic substrate of calories and acids) for treating pediatric adult patients with LC-FAODs. Study CL202 (NCT02214160), open-label extension study CL201 (NCT01886378), evaluated the long-term safety/efficacy triheptanoin LC-FAODs (N = 94), including cohorts who were naïve (n 33) or had...
Purpose: To investigate the immunoregulatory roles of adipose-derived mesenchymal stem cells (ADSCs) in autoimmune dacryoadenitis. Methods: Rabbits were treated with ADSCs or phosphate-buffered solution on days 1, 3, 5, 7, and 9 after injection activated peripheral blood lymphocytes, clinical scores determined by assessing tear production, break-up time, fluorescein hematoxylin eosin staining. Inflammatory response was measuring expression different mediators inflammation lacrimal glands....
Posaconazole (PCZ) is frequently used for prophylaxis against invasive fungal infections (IFI) in patients undergoing induction chemotherapy acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). commercially available as an oral suspension (PCZ-susp) and a delayed-release tablet (PCZ-tab). Differences absorption bioavailability between these formulations may result variability serum posaconazole concentrations. The primary objective of this retrospective analysis was to compare...
BackgroundCardiac resynchronization therapy (CRT) reduces mortality and improves outcomes in appropriately selected patients with heart failure (HF); however, response may vary.ObjectiveWe sought to correlate 6-month CRT assessed by clinical composite score (CCS) left ventricular end-systolic volume index (LVESVi) longer-term HF-related hospitalizations.MethodsIndividual patient data from 5 prospective studies—Multicenter InSync Randomized Clinical Evaluation (MIRACLE), Multicenter ICD...
Purpose . To observe ocular surface changes in Type II diabetic patients with different disease durations and to understand the correlations between clinical parameters durations. Methods In this cross-sectional, prospective study, 51 healthy controls 91 diabetes were enrolled. The diabetics divided into 3 subgroups according duration, including duration <10 y group, 10 20 ≥21 group. All subjects underwent examinations, lipid layer thickness (LLT), blinking rate, tear meniscus height...
Abstract An important mechanism involved in dry eye (DE) is the association between tear hyperosmolarity and inflammation severity. Inflammation DE might be mediated by NLRP3 inflammasome, which activated exposure to reactive oxygen species (ROS). A combination of carboxymethylcellulose (CMC) α-melanocyte stimulating hormone (α-MSH) may influence through this mechanism, thus avoiding defects signal drug. In study, we assessed whether treatment comprising CMC combined with α-MSH could...
The bactericidal function of neutrophils is dependent on a myriad intrinsic and extrinsic stimuli. Using systems immunology approaches we identify microbiome- infection-induced changes in neutrophils. We focus investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function. Murine human Pcyox1l proteins share ninety four percent aminoacid homology revealing significant evolutionary conservation implicating mediating important biological functions. Here show that loss results...