A5100667792- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Renal cell carcinoma treatment
- Hepatitis B Virus Studies
- Intestinal Malrotation and Obstruction Disorders
- Congenital gastrointestinal and neural anomalies
- Hepatitis Viruses Studies and Epidemiology
- Infant Nutrition and Health
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Diet and metabolism studies
- Hepatitis C virus research
- Vascular Malformations and Hemangiomas
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal disorders and treatments
- Lymphatic Disorders and Treatments
- Tracheal and airway disorders
- Drug Transport and Resistance Mechanisms
- Respiratory viral infections research
- Urological Disorders and Treatments
XinHua Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2025
Hubei University of Arts and Science
2025
Xiangyang Central Hospital
2025
Neusoft (China)
2024
Xiamen University
2014-2024
Wujiang District People's Hospital
2019-2024
Academia Sinica
2022-2023
Institute of Medical Biology
2016-2023
Abstract NF-κB is constitutively activated in psoriatic epidermis. However, how promotes keratinocyte hyperproliferation psoriasis largely unknown. Here we report that the activation triggered by inflammatory cytokines induces transcription of microRNA (miRNA) miR-31, one most dynamic miRNAs identified skin patients and mouse models. The genetic deficiency miR-31 keratinocytes inhibits their hyperproliferation, decreases acanthosis reduces disease severity Furthermore, protein phosphatase 6...
This study aimed to evaluate the relationship between gut probiotic flora and nonalcoholic fatty liver disease in a diet-induced rat model, compare effects of two different strains on disease. Forty male Sprague-Dawley rats were randomized into 4 groups for 12 weeks: control (standard chow), model (fat-rich diet), Lactobacillus diet plus acidophilus), Bifidobacterium longum) groups. Probiotics provided drinking water (10(10)/ml). Gut bifidobacteria lactobacilli obviously lower at weeks 8 10,...
Abstract Peripherally derived regulatory T (pT reg ) cell generation requires T-cell receptor (TCR) signalling and the cytokines TGF-β1 IL-2. Here we show that TCR induces microRNA miR-31, which negatively regulates pT -cell generation. miR-31 conditional deletion results in enhanced induction of cells, decreased severity experimental autoimmune encephalomyelitis (EAE). Unexpectedly, identify Gprc5a as a direct target miR-31. is known retinoic acid-inducible protein 3, its deficiency leads...
Mitophagy is a major pathway for clearance of injured mitochondria. However, whether mitophagy involved in the cholestasis-induced damages hepatic mitochondria remains unknown. We here aimed to investigate molecular links between cholestasis and mitophagy. show that increased significantly livers biliary atresia (BA) cholestatic disease infants. The mitochondrial-toxicity bile acids treatment increases activities hepatocytes. Mechanistically, we find prohibitin 2 (PHB2) crucial...
Hepatitis E virus (HEV) is a serious public health problem. The commonly used tests that are specific for current HEV infection diagnosis include the detection of anti-HEV IgM and RNA. Here, we report an improved enzyme-linked immunosorbent assay (ELISA) method antigen with linear range equivalent to 6.3 × 10(3) 9.2 10(5) RNA copies per ml. monoclonal antibody (MAb) 12F12, high-ability MAb binds virus, was selected as capture from panel 95 MAbs. positive period antigenemia in infected...
Biliary atresia (BA) is a severe chronic cholestasis disorder of infants that leads to death if not treated on time. Neonatal hepatitis syndrome (NHS) another leading cause neonatal confounding the diagnosis BA. Recent studies indicate altered bile acid metabolism closely associated with liver injury and cholestasis. In this study, we systematically measured metabolome in plasma BA, NHS, healthy controls. Liver acids were also using biopsy samples from 48 BA 16 NHS undergoing operative...
Abstract Chronic hepatitis B (CHB) is a global epidemic disease that may progress to fibrosis, cirrhosis and hepatocellular carcinoma. The role of the liver‐bile acid‐microbiota axis in CHB remains unclear. aims this study are elucidate alteration gut microbiota its functions bile acid homeostasis patients with different degrees fibrosis. In present study, we evaluated serum faecal profiles healthy controls biopsy‐proven diagnosis: had stage 0‐1 fibrosis were classified as mild 2‐4...