A5081057167- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiovascular Health and Risk Factors
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Gut microbiota and health
- Extracellular vesicles in disease
- Cancer therapeutics and mechanisms
- Analytical Chemistry and Sensors
- Multiple and Secondary Primary Cancers
- Circular RNAs in diseases
- Ophthalmology and Visual Health Research
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Advanced biosensing and bioanalysis techniques
- Diet, Metabolism, and Disease
- Photoacoustic and Ultrasonic Imaging
- Environmental Impact and Sustainability
Tongji University
2018-2024
Shanghai Pulmonary Hospital
2018-2024
Soochow University
2020-2023
Yangpu Hospital of Tongji University
2020
Gyeongju University
2016
Huazhong University of Science and Technology
2015
Renji Hospital
2009-2011
Shanghai Jiao Tong University
2011
This study aimed to evaluate the relationship between gut probiotic flora and nonalcoholic fatty liver disease in a diet-induced rat model, compare effects of two different strains on disease. Forty male Sprague-Dawley rats were randomized into 4 groups for 12 weeks: control (standard chow), model (fat-rich diet), Lactobacillus diet plus acidophilus), Bifidobacterium longum) groups. Probiotics provided drinking water (10(10)/ml). Gut bifidobacteria lactobacilli obviously lower at weeks 8 10,...
Abstract Though immunotherapy has to some extent improved the prognosis of patients with advanced non‐small cell lung cancer (NSCLC), only a few benefit. Furthermore, efficacy is affected by inflammatory and nutritional status patients. To investigate whether dynamics indexes were associated prognosis, 223 analysed retrospectively. The interest neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR) systemic immune‐inflammation index (SII) while prognostic (PNI) haemoglobin,...
Acquired resistance of osimertinib is encountered in clinic treatment non-small cell lung cancer (NSCLC).However, the molecular mechanisms are not fully revealed.This study aimed to investigate roles exosomes delivering NSCLC.Exosomes were successfully isolated.LncRNA sequencing identified a total 123 differentially expressed lncRNAs, including 45 upregulated lncRNAs and 78 downregulated lncRNAs.The relative expression level lncRNA MSTRG.292666.16 was significantly osimertinibresistant...
Abstract Exploiting photothermal agents with second‐near‐infrared (NIR‐II, 1000−1700 nm) emission and a high conversion efficiency (PCE) is an appealing challenging task. Herein, by simultaneously tailoring the D−A interaction planarity in fluorophores, two donor‐acceptor (D−A) −type semiconducting polymers (SPs), T‐BTP B‐BTP, are constructed. Compared T‐BTP, B‐BTP shows increased intramolecular interactions improved molecular planarity, leading to bathochromic‐shift absorption, NIR‐II...
Background Immunotherapies may prolong the survival of patients with small-cell lung cancer (SCLC) to some extent. The role forkhead box protein P3 (FOXP3) in tumor microenvironment (TME) remains controversial. We aimed examine FOXP3-related expression characteristics and prognostic values develop a clinically relevant predictive system for SCLC. Methods enrolled 102 histologically confirmed SCLC at stages I–III. Through immunohistochemistry, we determined pattern FOXP3 its association other...
Background: Conventional analysis of single-plex chromogenic immunohistochemistry (IHC) focused on quantitative but spatial analysis. How immune checkpoints localization related to non-small cell lung cancer (NSCLC) prognosis remained unclear.Methods: Here, we analyzed ten 1,859 tumor microarrays (TMAs) from 121 NSCLC patients and recruited an external cohort 30 with 214 whole-slide IHC. EfficientUnet was applied segment cells (TCs) tumor-infiltrating lymphocytes (TILs), while ResNet...
Circulating extracellular vesicle (EV) PD-L1 is correlated with the occurrence and progression of lung cancer has great potential as a valuable diagnostic immunotherapy predictive biomarker. In this work, we propose fluorescent biosensing method for sensitive accurate determination circulating EV PD-L1. Specifically, after phosphatidylserine-targeting peptide-assisted magnetic enrichment, programmable DNA circuit designed to translate presence appearance numerous duplex probes on surface....
Gefitinib is a potent inhibitor of EGFR and represents the front-line treatment for non-small cell lung cancer (NSCLC) therapeutics.However, NSCLC patients are prone to develop acquired resistance through as yet, undefined mechanisms resistance.Here, we investigated role COX-2 during gefitinib in cells revealed its underlying mechanism(s) action.We report upregulation gefitinib-resistant tissues cells, which associated with poor prognosis.In vitro assays (PC9/GR) showed that facilitates...
PurposeAlthough many studies have reported on the resistance mechanism of first-generation EGFR TKIs (1st TKIs) treatment, large-scale dynamic ctDNA mutation analysis based liquid biopsy for non-small cell lung cancer (NSCLC) in Chinese population is rare. Using in-depth integration and genomic data clinical at multiple time points during treatment 53 NSCLC patients, we described mechanisms 1st more comprehensively dynamically. The resulting profile polyclonal competitive evolution tumor...
Next-generation sequencing (NGS) and digital polymerase chain reaction (PCR) based platforms have been used to detect EGFR mutations in plasma circulating tumor DNA (ctDNA) with high accuracy. Generally, molecular testing is performed after histopathological analysis. However, many patients suspected advanced nonsmall cell lung cancer are unable undergo biopsy thus forgoing potential treatment highly effective tyrosine kinase inhibitors (TKIs) sensitizing mutations. We examined the utility...
Non-small cell lung cancer (NSCLC) represents the leading cause of cancer-related mortality worldwide. More and more reports have identified important roles for long noncoding RNAs (lncRNAs) in development. ENST457720 expression was upregulated adenocarcinoma a microarray-based lncRNA screen. We determined levels NSCLC tissues with quantitative real-time PCR then studied their clinical significance. explored biological significance gain- loss-of-function analyses vitro vivo. In this study,...
Nowadays, immune checkpoint blockades (ICBs) have been extensively applied in non-small cell lung cancer (NSCLC) treatment. However, the outcome of anti-program death-1/program death ligand-1 (anti-PD-1/PD-L1) therapy is not satisfying EGFR-mutant adenocarcinoma (LUAD) patients and its exact mechanisms fully understood. Since tumor mutation burden (TMB) phenotype had thought as potential predictors for efficacy ICBs, we further studied TMB LUAD to explore poor ICBs EGFR positive mutated find...
Interventional bronchoscopy exhibits substantial effects for patients with malignant airway obstruction (MAO), while little information is available regarding the potential prognostic factors these patients.Between October 31, 2016, and July 2019, a total of 150 undergoing interventional histologically-confirmed MAO were collected, in which 112 eligible participants formed cohort survival study. External validation from another independent institution comprised 33 therapeutic bronchoscopy....
Chemotherapy remains the basis of treatment lung cancer, and screening biomarkers with predictive value for chemotherapy is great interest. The present study focused on status genes methylation in NSCLC patients receiving pemetrexed- or gemcitabine-based chemotherapy.Promoter Ras association domain family (RASSF1A) short stature homeobox 2 (SHOX2) was examined bronchoalveolar lavage (BAL) from 117 treated chemotherapy. Multivariate analysis used to identify gene methylation. Progression-free...
Despite the benefit of adjuvant systemic therapy for patients with resected non-small cell lung cancer (NSCLC), risk postoperative recurrence remains high. Our objective was to characterize temporal genetic heterogeneity between primary and recurrent tumors, its impact on treatment outcomes. In this study, next-generation sequencing (NGS) testing performed tissue specimens circulating tumor DNA (ctDNA) collected at recurrence, results were compared genotypes initial surgical specimens. Of...
Objective To compare the prevalence rates of metabolic syndrome(MS)in obese children,according to three commonly used 'Pediatric MS definitions':(1)the International Diabetes Federation(IDF),(2)Cook,et al,and(3)da Silva,et al,in order choose an appropriate one for Chinese children.It was also intended assess variances American or cutoff values on prevalence.Methods A retrospective study performed in children from Obesity Outpatient Service Program January 2004 December 2008.Subjects were...
Abstract Background Considering the pivotal role of BIRC5 in tumorigenesis, recurrence, and chemoresistance, this study aimed to investigate its impact on clinical tumor microenvironmental features lung adenocarcinoma (LUAD), together with predictive prognostic values. Methods Clinical transcriptomic data 535 LUAD samples, 59 normal lung, 54 patients non-small-cell cancer (NSCLC) received immune checkpoint blockades (ICB) were analyzed. Deconvolution analysis was conducted uncover...
Low baseline prognostic nutritional index (PNI) scores are associated with poor survival for various malignancies; however, they vary based on the cohort and time resulting in inaccurate results. We determined predictive value of PNI score variations addition to patients advanced non-small cell lung cancer (NSCLC) who received programmed death protein 1 (PD-1) inhibitor.We retrospectively analysed 115 NSCLC PD-1 inhibitor. The median follow-up period was 28 months. Patients were clustered...