A5100413377- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Genetic Syndromes and Imprinting
- S100 Proteins and Annexins
- Cancer Immunotherapy and Biomarkers
- Genomics and Phylogenetic Studies
- Nicotinic Acetylcholine Receptors Study
- MicroRNA in disease regulation
- Dysphagia Assessment and Management
- Head and Neck Cancer Studies
- Olfactory and Sensory Function Studies
- Gut microbiota and health
- Single-cell and spatial transcriptomics
- Adipose Tissue and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Inflammation biomarkers and pathways
- Lipid metabolism and biosynthesis
- Plant tissue culture and regeneration
- Colorectal Cancer Treatments and Studies
Lanzhou University
2025
Lanzhou University Second Hospital
2025
China Medical University
2025
First Hospital of China Medical University
2025
Renji Hospital
2025
Shanghai Jiao Tong University
2022-2025
First Affiliated Hospital of Henan University
2022-2024
First Affiliated Hospital Zhejiang University
2024
Zhejiang University
2014-2024
University of Missouri Health System
2024
CBX3, namely chromobox protein homolog 3, a member of the heterochomatin 1 (HP1) family, has been shown to be associated with tumorigenesis various types cancer. The aim present study was assess biological role and clinicopathological importance CBX3 in osteosarcoma. Oncomine database utilized determine expression sarcoma patients. A retrospective cohort conducted evaluate prognostic value expression. In addition, correlations between features osteosarcoma patients were assessed involved...
Polycomb repressive complex 2 (PRC2) is responsible for depositing H3K27me3 and plays essential roles in gene silencing during development cancer. Meanwhile, the nuclear exosome targeting (NEXT) facilitates degradation of numerous noncoding RNAs nucleoplasm. Here we find that functional deficiency NEXT leads to an overall decrease levels. Specifically, ZCCHC8 depletion results significant upregulation nascent long (lncRNAs) containing G-quadruplex (G4) U-Rich motifs (G4/U-Rich lncRNAs). The...
Acetyl-CoA acyltransferase 1 ( ACAA1 ) functions as a key regulator of fatty acid β-oxidation in peroxisomes by catalyzing the cleavage 3-ketoacyl-CoA to acetyl-CoA and acyl-CoA, which participate extension degradation acids. Thus, is an important lipid metabolism plays essential role oxidation metabolism. Our previous study findings revealed that closely associated with peroxisome proliferator-activated receptor PPAR signaling pathways, are involved fat deposition sheep, leading our...
Colorectal melanoma (CRM) is a rare malignant tumor with severe complications, and there currently lack of systematic research. We conducted study that combined proteomics mutation data CRM from cohort three centers over 16-years period (2005–2021). The patients were divided into training set consisting two testing comprising the other center. Unsupervised clustering was on to form molecular subtypes for clinical characterization functional analysis. used validate survival differences...
<i>Aims:</i> Emerging evidence suggests that the urinary excretion of cytokines is associated with progression chronic kidney disease (CKD). However, detection in high throughput still a problem clinical practice. In this cross-sectional study, we applied novel proteomic technology, antibody array, to analyze cytokine profiles patients CKD. <i>Methods:</i> A total 10 subjects including 7 CKD and 3 normal controls were studied. These divided into two groups according...
To develop potent and environment-friendly insecticides, novel N-pyridylpyrazole amide derivatives containing a phthalimide were designed synthesized. The preliminary bioassay results showed that most of the target compounds exhibited good insecticidal activities. For oriental armyworm (Mythimna separata), E5, E29, E30, E33 displayed higher than 90% lethal rates at 25 mg L-1. In particular, compound 60% mortality lower concentration 6.25 Besides, also 30% rate 5 L-1 against diamondback moth...
In our previous taste-masking study, we found that Acesulfame K (AK) had a better effect than other high-efficiency sweeteners for several representative bitter natural drugs in aqueous decoction. Furthermore, performed preliminary study of AK API Berberine Hydrochloride (BH) and it good effect. We also flocculent precipitation was generated the BH solution, but not clear whether related to This conducted explore mechanism on BH.The evaluated based Traditional Human Taste Panel Method...
The monoterpenes linalool and its oxides are the key aroma-active compounds in Osmanthus fragrans Lour. flowers. glycosides of these accumulate throughout flowering, leading to considerable storage potential aroma constituents that account for majority non-volatile compounds. However, UDP-glycosyltransferase (UGT) responsible glycosylation has not been clarified. Four candidate OfUGTs (UGT85A82, UGT85A83, UGT85AF3, UGT85A84) with high homology known terpenoid UGTs were screened by...
Abstract To determine the optimal embryogenic capacity (somatic embryo production) of selected elite nematode-resistant genotypes Pinus thunbergii , variables such as tissue (ET) morphology, maternal genotype, proliferation rate and age were analyzed. ET morphology histological evaluation stage showed a decrease in filamentous clump protuberant surfaces decline acetocarmine-staining area, which indicates somatic production (SEP). Variations cell physiology during that SEP was positively...
Denoising diffusion models have emerged as one of the most powerful generative in recent years. They achieved remarkable success many fields, such computer vision, natural language processing (NLP), and bioinformatics. Although there are a few excellent reviews on their applications vision NLP, is lack an overview This review aims to provide rather thorough bioinformatics aid further development computational biology. We start with introduction key concepts theoretical foundations three...
The genome-wide single-cell chromosome conformation capture technique, i.e. Hi-C (ScHi-C), was recently developed to interrogate the of genome individual cells. However, data are much sparser than bulk a population cells, and noise in makes it difficult apply analyze them biological research. Here, we first generative diffusion models (HiCDiff) denoise form chromosomal contact matrices. HiCDiff uses deep residual network remove reverse process can be trained both unsupervised supervised...
Postmenopausal osteoporosis (PMOP), as well its associated increased risk for fragility fracture, is one of the most disabling consequences aging in women. This present study aimed to identify candidate genes that involve pathogenesis PMOP and therapeutic mechanism Liuweidihuang (LWDH) pills on PMOP. We integrated microarray datasets derived from Gene Expression Omnibus (GEO) screen differentially expressed (DEGs) between normal controls patients with after treatment LWDH pills. GO KEGG...
The Tsc1-mTOR signaling pathway is often related to obesity, and epigenetic modification may lead expression changes of obesity-related gene. Therefore, we aim investigate the methylation in regulation obesity susceptibility. Wistar rats were fed a normal diet or high-fat develop animal models. Protein mRNA levels hypothalamus determined by Western blot quantitative real-time PCR. Methylation Tsc1 gene promoter was detected bisulfite genomic sequence. Both protein DIO group lower; mTOR its...
Endometrial carcinoma is one of the most common gynecologic malignancies. Estrogen plays a critical role in its pathogenesis, but underlying mechanism not clear. Nucleophosmin 1 (NPM1), multifunctional protein involved many cellular activities, has been implicated tumorigenesis processes. However, NPM1 endometrial carcinogenesis remains to be elucidated. The present study was aimed elucidate different clinical stages human and action.The distribution expression normal endometrium, FIGO I IV...
Objective To explore the relationships between swallowing functional outcomes and nutritional status in patients with head neck cancer undergoing radiotherapy (RT). Methods This longitudinal study included 122 patients. Data were collected at three time points: baseline (T 1 ), third week of RT 2 ) completion 3 ). The Common Terminology Criteria for Adverse Events was used to assess symptom dysphagia other toxicities; MD Anderson Dysphagia Inventory (MDADI) patient-perceived outcomes;...
In this study, clinical biochemistry, hematology, histopathology and (1)H nuclear magnetic resonance spectroscopy-based metabonomic approaches were applied to investigate the toxicological effects of Shuanghuanglian (SHL) injection after intravenous administration (dosed at 4, 12 36 mL stock/kg) in Beagle dogs for 30 d. Decreases red blood cells, hemoglobin, mean cell volume, corpuscular hemoglobin concentration observed high-dose group. Elevated reticulocytes, total bilirubin direct also...
Long-chain fatty acyl-CoA synthetase (ACSLs) is an essential enzyme for the synthesis of acyl-CoA. ACSL1 plays a key role in triglycerides, phospholipids, and cholesterol esters. Background: In current study, triglyceride content did not increase after overexpression gene. Methods: RNA-seq lipid metabolome profiling were performed to determine why levels change with overexpression. Results: Fatty produced by was determined be involved diglyceride pathway, significantly increased when...
Abstract In this article, bulk copolymerization of methyl methacrylate (MMA) with ethyl (EMA) and n ‐butyl ( ‐BMA) was carried out at 60°C. The monomer reactivity ratios obtained by nonlinear fitting Mayo‐Lewis equation were as follows: r MMA = 0.93 ± 0.03, EMA 0.96 0.03 for the MMA/EMA, 0.99 0.05, ‐BMA 1.11 0.06 MMA/ series. A new proposed in view bond rotation flexibility (Liu et al., J Phys Chem B 2008, 112, 93), which contains mole fractions triads T g 's corresponding periodic...