A5081494208- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Genomics, phytochemicals, and oxidative stress
- Hormonal and reproductive studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Cancer-related molecular mechanisms research
- Anesthesia and Sedative Agents
- Mitochondrial Function and Pathology
- Respiratory Support and Mechanisms
- Molecular Biology Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Reproductive tract infections research
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Elbow and Forearm Trauma Treatment
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Pain Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Glutathione Transferases and Polymorphisms
- Mycotoxins in Agriculture and Food
Hubei University of Technology
2025
Hebei Medical University
2015-2024
Qingdao Agricultural University
2017-2024
Beijing Technology and Business University
2024
Northwest A&F University
2017-2023
Inner Mongolia Medical University
2021-2023
Tengzhou Central People's Hospital
2023
Sunonwealth Electric Machine Industry (Taiwan)
2023
Putian University
2023
Huawei Technologies (China)
2021
To evaluate clinically and radiographically an alveolar ridge, preservation technique with deproteinized bovine bone graft absorbable collagen membrane then restoration delayed implants were done. The study included 30 patients. trial group's sockets filled (Bio-Oss) covered (Bio-Gide). control healed without any treatment. Panoramic radiograph computed tomography taken immediately after 3 6 months later to the height, width, volume change of ridge bone. Dental inserted in all at months,...
With global carbon emissions continuing to rise and urban energy demands growing steadily, understanding how block morphology impacts building photovoltaic (PV) efficiency consumption has become crucial for sustainable development climate change mitigation. Current research primarily focuses on individual optimization, while block-scale coupling relationships between PV utilization remain underexplored. This study developed an integrated prediction optimization tool using deep learning...
Testosterone deficiency, as a potential risk factor for aging and aging-related neurodegenerative disorders, might induce mitochondrial dysfunction facilitate the declines of nigrostriatal dopaminergic system by exacerbating defects increasing oxidative damage. Thus, how testosterone levels influence function in substantia nigra was investigated study. The present studies showed that deficiency impaired induced damage to well deficits system. Of four respiratory chain complexes, castration...
Alzheimer's disease (AD) is a common chronic progressive neurodegenerative disorder, and curative treatment has not been developed. The objective of this study was to investigate the potential effects hydralazine (Hyd, hypertension drug) on development process AD its mechanisms. We treated 6-month-old male APP/PS1 mice with Hyd for 5 weeks, measured changes in behavior pathological status, analyzed differences gene expression by RNA sequencing. results demonstrated that improved cognitive...
Abstract Androgen plays a pivotal role in the progression of renal fibrosis. However, whether exogenous androgen treatment to aged male rats can improve age-related fibrosis was not explored. In our study, changes morphological structure, fibrosis, ultrastructure and function, expressions extracellular matrix (ECM), metalloproteinases (MMPs) its tissue inhibitors (TIMPs), tumor growth factor β1 (TGF-β1)/Smad signaling oxidative stress parameters as well nuclear erythroid 2-related...
A recent cluster of pneumonia cases in Wuhan (China) is known to be caused by a novel beta-coronavirus named the corona virus disease 2019 (COVID-19) and can spread through human-to-human transmission.Data 21 patients with laboratory-confirmed COVID-19 84 suspected were analyzed RT-PCR. The epidemiologic clinical features as well outcomes compared between confirmed cases.Altogether 105 had been enrolled this study February 15, 2020 north Shanghai, including COVID-19. incubation period these...
Background Recent studies show testosterone (T) deficiency worsens cognitive impairment in Alzheimer’s disease (AD) patients. Mitochondrial dysfunction, as an early event of AD, is becoming critical hallmark AD pathogenesis. However, currently, whether T exacerbates mitochondrial dysfunction men with remains unclear. Objective The purpose this study to explore the effects on male mouse models and its potential mechanisms. Methods animal model was performed by castration 3-month-old APP/PS1...
Abstract Low sperm motility is a significant contributor to male infertility. beta-defensins have been implicated in host defence and the acquisition of motility; however, regulatory mechanisms governing their gene expression patterns functions remain poorly understood. In this study, we performed single-cell RNA spatial transcriptome sequencing investigate cellular composition testicular epididymal tissues examined characteristics. epididymis, found that epithelial cells display region...
Currently, there are no effective therapeutic agents available to treat Alzheimer's disease (AD). However, edaravone dexborneol (EDB), a novel composite agent used acute ischemic stroke, has recently been shown exert efficacious neuroprotective effects. whether EDB can ameliorate cognitive deficits in AD currently remains unclear. To this end, we explored the effects of on and its potential mechanisms using an animal model (male APP/PS1 mice) treated with for 10 weeks starting at 6 months...
Zearalenone (ZEA) is a natural contaminant of various food and feed products representing significant problem worldwide. Since the occurrence ZEA in grains feeds frequent, present study was carried out to evaluate possible effects on steroid production gene expression porcine granulosa cells, using RNA-seq analysis. Porcine cells were administered 10 μM 30 during 72 h culture vitro. Following treatment profile control exposed compared The results showed that significantly altered transcript...
Postmenopausal osteoporosis (PMOP), as well its associated increased risk for fragility fracture, is one of the most disabling consequences aging in women. This present study aimed to identify candidate genes that involve pathogenesis PMOP and therapeutic mechanism Liuweidihuang (LWDH) pills on PMOP. We integrated microarray datasets derived from Gene Expression Omnibus (GEO) screen differentially expressed (DEGs) between normal controls patients with after treatment LWDH pills. GO KEGG...
Brain mitochondrial dysfunction and reduced testosterone levels are common features of aging in men. Although evidence suggests that the two phenomena interrelated, it is unclear whether supplementation ameliorates male brain. Here, we show significantly alleviates exploratory behavioral deficits oxidative damage substantia nigra hippocampus rats. These effects were consistent with improved function, reflected by testosterone-induced increases membrane potential (MMP), antioxidant enzyme...
Abstract The present study aimed to evaluate the protective efficacy of testosterone propionate (TP) on age-related liver changes via activation nuclear factor erythroid 2-related 2-antioxidant response element (Nrf2-ARE) pathway in aged rats. Aged rats received subcutaneous injections TP (2 mg/kg/d, 84 days). Oxidative stress parameters and expression levels signal transducer activator transcription 5b (STAT5b), Kelch-like ECH associating protein-1 (Keap1), Nrf2, haem oxygenase-1 (HO-1)...
There is a controversy over the effects of testosterone supplements on dopaminergic function. Both neuroprotective and toxic are reported. The status oxidative stress seems to explain or properties testosterone. To determine efficacy in different stress, present studies analyzed dopamine (DA)-related behaviors neurochemical indices, as well markers nigrostriatal (NSDA) system reserpine-treated aged male rats followed by propionate (TP) supplements. experimental animals was evaluated...
Deficits in coordinated motor behavior and mitochondrial complex V activity have been observed aged males.Testosterone supplementation can improve males.We investigated the effects of testosterone on function substantia nigra (a brain region that regulates activity) male rats.These rats exhibited diminished ATP levels, attenuated activity, reduced expression 3 17 subunits (ATP6, ATP8 ATP5C1) nigra.Testosterone increased ATP6, ATP5C1 rats.Conversely, orchiectomy downregulated ATP6 expression,...
Pentoxifylline (PTX) is a non-specific phosphodiesterase inhibitor with pleiotropic effects that routinely used to treat peripheral vascular disease. In this study, we tested whether PTX could also counteract the detrimental of aging in brain. To accomplish that, treated aged rats and measured resulting behavioral alterations as well changes dopaminergic neurochemical levels, oxidative balance markers, mitochondrial function, nuclear factor erythroid 2-related 2 (Nrf2), peroxisome...