A5001512334- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Mycotoxins in Agriculture and Food
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- TGF-β signaling in diseases
- RNA modifications and cancer
- Cerebral Palsy and Movement Disorders
- Sulfur Compounds in Biology
- Selenium in Biological Systems
- Phytoestrogen effects and research
- Birth, Development, and Health
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
- Botulinum Toxin and Related Neurological Disorders
- Urinary Bladder and Prostate Research
- Circular RNAs in diseases
- Oral health in cancer treatment
- Reproductive Physiology in Livestock
- Acupuncture Treatment Research Studies
- Trace Elements in Health
Institute of Animal Sciences
2016-2025
Chinese Academy of Agricultural Sciences
2016-2025
Qingdao Agricultural University
2015-2024
Xian Central Hospital
2017-2024
Chinese Academy of Tropical Agricultural Sciences
2024
Yunnan Academy of Agricultural Sciences
2024
Beijing Children’s Hospital
2022-2024
Harbin Institute of Technology
2024
Chinese People's Liberation Army
2024
Murdoch University
2021-2023
Abstract Legumain is required for maintenance of normal kidney homeostasis. However, its role in acute injury (AKI) still unclear. Here, we induced AKI by bilateral ischemia-reperfusion (IRI) renal arteries or folic acid lgmn WT and KO mice. We assessed serum creatinine, blood urea nitrogen, histological indexes tubular injury, expression KIM-1 NGAL. Inflammatory infiltration was evaluated immunohistological staining CD3 F4/80, TNF-α, CCL-2, IL-33, IL-1α. Ferroptosis Acsl4, Cox-2, reactive...
Caffeic acid (CA) is one of the major phenolic acids coffee with multiple biological activities. Our previous study found that 500 mg/kg chlorogenic (CGA) had potential capacity alleviating colonic inflammation. Moreover, CGA can be degraded into caffeic by gut microbiota in colon. Therefore, we hypothesize CA exert protective effects on To test hypothesis, 251 was supplemented to DSS-induced colitis mice. The results showed treatment recovered disease activity index (DAI), colon length, and...
MicroRNAs (miRNAs) are a class of short noncoding RNAs that regulate protein-coding genes posttranscriptionally. In animals, most known miRNA targeting occurs within the 3'UTR mRNAs, but extent biologically relevant in ORF or 5'UTR mRNAs remains unknown. Here, we develop an algorithm (MinoTar-miRNA Targets) to identify conserved regulatory motifs regions and use it estimate number preferentially miRNA-target sites ORFs. We show that, Drosophila, ORFs is as widespread 3'UTRs while far less...
Arsenic is a well-recognized human carcinogen, yet the mechanism by which it causes cancer has not been elucidated. MicroRNAs (miRNAs) are big family of small noncoding RNAs and negatively regulate expression large number protein-coding genes. We investigated role miRNAs in arsenic-induced bronchial epithelial cell malignant transformation tumor formation. found that prolonged exposure immortalized p53-knocked down cells (p53lowHBECs) to low levels arsenite (NaAsO2, 2.5 μM) caused was...
Rationale: Busulfan is currently an indispensable anti-cancer drug, particularly for children, but the side effects on male reproduction are so serious that critical drug management needed to minimize any negative impact. Meanwhile, alginate oligosaccharides (AOS) natural products with many consequent advantages, have attracted a great deal of pharmaceutical attention. In current investigation, we performed single-cell RNA sequencing murine testes treated busulfan and/or AOS define...
Abstract Background The increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal microbiota transplantation (FMT) have been used to minimize mucositis. However, it is still unknown whether FMT from a donor with beneficial gut results in more effective function the recipient. Recently, we found that alginate oligosaccharides (AOS) benefit murine through “beneficial” microbes rescue busulfan Results In...
Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” Chinese) Scutellaria baicalensis (“Huangqin” are two traditional Chinese medicinal plants rich polyphenols, such as chlorogenic acid (CGA) baicalin (BA), with effects of anti-inflammation antioxidation. However, it remains unknown whether extracts from L. S. (LSEs) could mitigate colonic inflammation. In present study, ICR mice (22.23 ± 1.65 g)...
Abstract Background Clinical data suggest that male reproductive dysfunction especially infertility is a critical issue for type 1 diabetic patient (T1D) because most of them are at the age. Gut dysbiosis involved in T1D related infertility. However, improved gut microbiota can be used to boost spermatogenesis and fertility remains incompletely understood. Methods was established ICR (CD1) mice with streptozotocin. Alginate oligosaccharide (AOS) (fecal transplantation (FMT) from AOS...
Post-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The intestinal epithelial cells microbiota reciprocally regulate each other order to maintain homeostasis control inflammation. However, a relative paucity of research has been focused on the host-derived regulatory network that controls mucin O-glycans changes gut during infancy. At development stage just after birth, ontogeny epithelium, immune system, appear...
Young type 2 diabetes (T2D) affects 15% of the population, with a noted increase in cases, and T2D-related male infertility has become serious issue recent years. The current study aimed to explore improvements alginate oligosaccharide (AOS)-modified gut microbiota on semen quality T2D. T2D was established young mice 5 weeks age blood glucose level 21.2 ± 2.2 mmol/L, while 8.7 1.1 mM control animals. We discovered that fecal transplantation (FMT) AOS-improved (A10-FMT) significantly...
High-fat diet (HFD)-induced obesity is known to be associated with reduced male fertility and decreased semen quality in humans. HFD-related infertility a growing issue worldwide, it crucial overcome this problem ameliorate the distress of infertile couples. For first time, we discovered that fecal microbiota transplantation (FMT) alginate oligosaccharide (AOS)-improved gut (A10-FMT) ameliorated HFD-decreased (sperm concentration: 286.1 ± 14.1 versus 217.9 17.4 million/mL; sperm motility:...
Perfluorooctanoic acid (PFOA) is a synthetic, widely used perfluorinated carboxylic and persistent environmental pollutant. It an agonist of peroxisome proliferator–activated receptor α (PPARα). Studies have shown that PFOA causes hepatocellular hypertrophy, tumorigenesis, developmental toxicity in rodents, some its depends on the expression PPARα. Our recent study revealed stimulatory effect peripubertal treatment (5 mg/kg) mammary gland development C57Bl/6 mice. The present was designed to...
Zearalenone (ZEA), a metabolite of Fusarium fungi, is commonly found on moldy grains.Because it can competitively combine to estrogen receptor disrupt estrogenic signaling, has been reported have serious adverse effects animal reproduction systems.In order explore the genotoxic ZEA exposure ovarian somatic cells, porcine granulosa cells were exposed 10 μM and 30 for 24 or 72 h in vitro.The results showed that remarkably reduced proliferation dose-dependent manner as determined by MTT...
Abstract A number of emerging studies suggest that air pollutants such as hydrogen sulfide (H 2 S) and ammonia (NH 3 ) may cause a decline in spermatozoa motility. The impact underlying mechanisms are currently unknown. Boar ( vitro peripubertal male mice vivo were exposed to H S and/or NH evaluate the on Na 4 Cl reduced motility boar vitro. disrupted multiple signaling pathways including decreasing + /K ATPase activity protein kinase B (AKT) levels, activating Adenosine 5′-monophosphate...
Abstract A growing number of couples experience fertility issues with almost half being due to malefactors. The exposure toxic environmental contaminants, such as endocrine disruptors ( ED s), has been shown negatively affect male fertility. s are present in the environment, and these toxins results failure spermatogenesis. deleterious effects on spermatogenesis have well documented, whereas improvement infertility associated defects remains a great challenge. Herein, we report that vitro...
Zinc oxide nanoparticles (ZnO NPs) are used widely in consumer and industrial products, however, their influence on gut microbiota metabolism mutual interactions not fully understood. In this study, the effects of ZnO NPs ileal bacterial communities, plasma metabolites, correlations between them were investigated. Hens fed with different concentrations [based Zn; 0 mg/kg (control), 25 mg/kg, 50 100 mg/kg] for 9 weeks. Subsequently, digesta blood collected analysis microflora respectively....
It is generally accepted that significant germ cell loss occurs during the establishment of primordial follicle pool in most mammalian ovaries around time birth.However, underlying mechanisms responsible for these processes remain largely unknown.In this investigation, we explored role autophagy and found was active process.Our data suggested 17.5 dpc treated with rapamycin displayed a delay cyst breakdown resulting more oocytes at day 5 treatment, while, 3-MA showed opposite effect.We...