Caffeic acid (CA) is one of the major phenolic acids coffee with multiple biological activities. Our previous study found that 500 mg/kg chlorogenic (CGA) had potential capacity alleviating colonic inflammation. Moreover, CGA can be degraded into caffeic by gut microbiota in colon. Therefore, we hypothesize CA exert protective effects on To test hypothesis, 251 was supplemented to DSS-induced colitis mice. The results showed treatment recovered disease activity index (DAI), colon length, and...

The purpose of the current study was to investigate effect dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ (3 g kg-1) throughout study, starting 14 days prior DSS treatment for 1 week followed by 2 without DSS. results showed that restored DSS-induced disease activity index (DAI), colon length and histopathology scores tissue. Additionally, with reduced pro-inflammatory cytokine levels, enhanced level IL-10 serum....

Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” Chinese) Scutellaria baicalensis (“Huangqin” are two traditional Chinese medicinal plants rich polyphenols, such as chlorogenic acid (CGA) baicalin (BA), with effects of anti-inflammation antioxidation. However, it remains unknown whether extracts from L. S. (LSEs) could mitigate colonic inflammation. In present study, ICR mice (22.23 ± 1.65 g)...

CA supplementation could enhance intestinal integrity and barrier function by modifying microbiota its metabolites, which lead to a reduction in inflammatory responses oxidative stress LPS-challenged piglets.

Alternatives to antibiotics for improving productivity and maintaining the health of livestock are urgently needed. The scope this research was conducted investigate effects two alternatives (Bacillus licheniformis Saccharomyces cerevisiae) monensin on growth performance, antioxidant capacity, immunity, ruminal fermentation microbial diversity fattening lambs. One hundred sixty Dorper × Thin-tailed Han sheep (32 ± 3.45 kg BW) were randomly assigned into 5 treatments n = 32 lambs/group. Lambs...

Oxidative stress, one of the most common biological dysfunctions, is usually associated with pathological conditions and multiple diseases in humans animals. Chinese olive fruit ( Canarium album L.) extracts (OE) are natural plant rich polyphenols (such as hydroxytyrosol, HT) antioxidant, anti-hyperlipidemia, anti-inflammatory potentials. This study was conducted to investigate antioxidant capacity OE supplementation its related molecular mechanism mice. Mice (25.46 ± 1.65 g) were treated...

Chemically protected sodium butyrate (CSB) is a new kind of butyrate. Our previous study found that 1,000 mg/kg CSB had the potential capacity improving growth performance and promoting early development small intestine in broilers. This aimed to investigate effect long-term antibiotics or supplementation for intestinal microflora dynamical regulation One hundred ninety-two 1-day-old Arbor Acres male broilers were randomly allocated into 3 dietary treatment (8 replicates per treatment) fed...

Oxidative stress is a major pathogenic factor in many intestinal diseases, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Nrf2 signaling pathway mitophagy can reduce reactive oxygen species (ROS) alleviate oxidative stress, but their relationship unclear. Hydroxytyrosol (HT), polyphenolic compound abundant olive oil, has strong antioxidant activity may help treat these diseases. We used pigs model to investigate HT's effect on damage its mechanisms. Diquat (DQ)...

Young animals are highly susceptible to intestinal damage due incomplete development, making them vulnerable external stimuli. Weaning stress in piglets, for instance, disrupts the balance of microbiota and metabolism, triggering inflammation resulting gut damage. Caffeic acid (CA), a plant polyphenol, can potentially improve health. Here, we evaluated effects dietary CA on barrier using lipopolysaccharide (LPS)-induced model. Eighteen piglets were divided into three groups: control group...

Introduction Cordyceps militaris extract (CME) and cordycepin (CPN) are biomolecules with a wide range of biological activities, including anti-inflammatory, antioxidant anti-tumour effects. The research objective wasto investigate the influences CME CPN on colonic morphology, microbiota composition metabolomics in lipopolysaccharide (LPS)-challenged piglets. Methods Twenty-four weaned castrated piglets were randomly divided into four groups: control group (fed basal diets), LPS CPN-LPS...

Chlorogenic acid (CGA) is an important source of phenolic acids with multiple health functions such as antioxidation, anti-inflammation, and free radical scavenging effects. This study aimed to investigate whether the nuclear factor erythroid 2-related 2 (Nrf-2)/HO-1 pathway played a role in CGA ameliorating DSS-induced colitis mice. 500 mg/kg (high chlorogenic acid, HCGA) 250 (low LCGA) supplementation could alleviate symptoms related mechanisms. qPCR results indicated that HCGA treatment...

Cordycepin is considered a major bioactive component in Cordyceps militaris extract. This study was performed to evaluate the ameliorative effect of extract (CME) and cordycepin (CPN) supplementation on intestinal damage LPS-challenged piglets. The results showed that CPN or CME significantly increased villus height (p < 0.01) height/crypt depth ratio 0.05) jejunum ileum piglets with LPS-induced inflammation. Meanwhile, alleviated oxidative stress inflammatory responses by reducing levels...

This study compared the growth performance, nutrient utilization, and slaughter traits of Dorper crossbred male lambs fed as per established nutrition recommendations for sheep, with an aim to verify efficacy different feeding standards. A total 576 (4 months age, 28.3 ± 0.86 kg BW) were randomly allotted 3 treatments 12 replicates treatment (16 replicate). The diets formulated according following nutritional systems: requirements by Chinese Academy Agricultural Sciences (CAAS), NRC...

The role of neutrophils in cancer has been the subject intense research recent years. One major theme that emerged is not all are equal field cancer. However, it remains unclear what induces protumorigenic or antitumorigenic phenotype predominate tumor. Therefore, this study aimed to investigate factors induce which these two phenotypes neutrophil OSCC and explore polarization on tumor.Immunofluorescence immunohistochemistry staining were used observe infiltration expression TGF-β1 IL-17A...

Colorectal cancer (CRC) is a prevalent and lethal tumor, with metastasis being the leading cause of mortality. Previous research has indicated that long non-coding RNA (lncRNA) CCAT2 involved in regulation various tumor progression mechanisms. However, precise role CRC proliferation remains ambiguous. This study seeks to elucidate mechanisms through which influences CRC. High-throughput sequencing RT-qPCR were used detect expression Functional analyses including CCK8, colony formation, wound...

The aim of the present study was to investigate effects transcription factor forkhead box P3 (FOXP3) in neutrophils on progression oral squamous cell carcinoma (OSCC). Cancer tissue samples and paracarcinoma tissues were collected from 23 patients with OSCC for current study. In addition, SCC‑9, a human tongue line, co‑cultured primary treated recombinant interleukin 8 (IL‑8). effect FOXP3 proliferation SCC‑9 cells analyzed using Cell Counting Kit assay. expression by quantitative PCR...

Dihydroquercetin (DHQ) is a natural flavonoid with multiple bioactivities, including hepatoprotective effects. This study aimed to investigate whether DHQ improved lipid dysmetabolism in the body, especially liver, and there relationship between hepatic metabolism altered gut flora high-fat diet (HFD)-induced mice. HFD-induced mice were given 50 mg/kg body weight intragastrically for 10 weeks. The data showed that reduced weight, of liver white adipose tissue as well serum leptin, LPS,...

Infants and young animals often suffer from intestinal damage caused by oxidative stress, which may adversely affect their overall health. Hydroxytyrosol, a plant polyphenol, has shown potential in decreasing but its application mechanism of action infants are still inadequately documented. This study selected piglets as model to investigate the alleviating effects hydroxytyrosol on stress induced diquat mechanism. Hydroxytyrosol improved morphology, characterized higher villus height...