Caffeic acid (CA) is one of the major phenolic acids coffee with multiple biological activities. Our previous study found that 500 mg/kg chlorogenic (CGA) had potential capacity alleviating colonic inflammation. Moreover, CGA can be degraded into caffeic by gut microbiota in colon. Therefore, we hypothesize CA exert protective effects on To test hypothesis, 251 was supplemented to DSS-induced colitis mice. The results showed treatment recovered disease activity index (DAI), colon length, and...

The purpose of the current study was to investigate effect dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ (3 g kg-1) throughout study, starting 14 days prior DSS treatment for 1 week followed by 2 without DSS. results showed that restored DSS-induced disease activity index (DAI), colon length and histopathology scores tissue. Additionally, with reduced pro-inflammatory cytokine levels, enhanced level IL-10 serum....

Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” Chinese) Scutellaria baicalensis (“Huangqin” are two traditional Chinese medicinal plants rich polyphenols, such as chlorogenic acid (CGA) baicalin (BA), with effects of anti-inflammation antioxidation. However, it remains unknown whether extracts from L. S. (LSEs) could mitigate colonic inflammation. In present study, ICR mice (22.23 ± 1.65 g)...

Xylo-oligosaccharides (XOS) is a well-known kind of oligosaccharide and extensively applied as prebiotic. The objective this study was to investigate the effect XOS supplementation substituting chlortetracycline (CTC) on growth, gut morphology, microbiota, hindgut short chain fatty acid (SCFA) contents weaning piglets. A total 180 weaned piglets were randomly allocated three treatments for 28 days, follows: control group (basal diet, CON), basal diet with 500 mg/kg (XOS500) XOS, positive 100...

Abstract Background Clinical data suggest that male reproductive dysfunction especially infertility is a critical issue for type 1 diabetic patient (T1D) because most of them are at the age. Gut dysbiosis involved in T1D related infertility. However, improved gut microbiota can be used to boost spermatogenesis and fertility remains incompletely understood. Methods was established ICR (CD1) mice with streptozotocin. Alginate oligosaccharide (AOS) (fecal transplantation (FMT) from AOS...

Post-weaning diarrhea in piglets reduces growth performance and increases mortality, thereby causing serious economic losses. The intestinal epithelial cells microbiota reciprocally regulate each other order to maintain homeostasis control inflammation. However, a relative paucity of research has been focused on the host-derived regulatory network that controls mucin O-glycans changes gut during infancy. At development stage just after birth, ontogeny epithelium, immune system, appear...

High-fat diet (HFD)-induced obesity is known to be associated with reduced male fertility and decreased semen quality in humans. HFD-related infertility a growing issue worldwide, it crucial overcome this problem ameliorate the distress of infertile couples. For first time, we discovered that fecal microbiota transplantation (FMT) alginate oligosaccharide (AOS)-improved gut (A10-FMT) ameliorated HFD-decreased (sperm concentration: 286.1 ± 14.1 versus 217.9 17.4 million/mL; sperm motility:...

Young type 2 diabetes (T2D) affects 15% of the population, with a noted increase in cases, and T2D-related male infertility has become serious issue recent years. The current study aimed to explore improvements alginate oligosaccharide (AOS)-modified gut microbiota on semen quality T2D. T2D was established young mice 5 weeks age blood glucose level 21.2 ± 2.2 mmol/L, while 8.7 1.1 mM control animals. We discovered that fecal transplantation (FMT) AOS-improved (A10-FMT) significantly...

This study aimed to evaluate the individual and combined effects of chemically protected sodium butyrate (CSB) xylo-oligosaccharide (XOS) on performance, anti-inflammatory antioxidant capacity, intestinal morphology microbiota broilers. A total 280 one-day-old Arbor Acres broilers were randomly distributed into 5 treatments: basal diet (CON), supplemented with 100 mg/kg aureomycin 8 enramycin (ABX), 1000 CSB (CSB), XOS (XOS), mixture (MIX), respectively. On d 21, ABX, CSB, MIX decreased feed...

CA supplementation could enhance intestinal integrity and barrier function by modifying microbiota its metabolites, which lead to a reduction in inflammatory responses oxidative stress LPS-challenged piglets.

Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator, promoting development and regulating flora in the gut. However, relevant mechanisms remain obscure. In this study, pigs were fed corn-soybean meal-based diet supplemented with either 5% microcrystalline cellulose (MCC) or pectin for 3 weeks, to investigate metabolites anti-inflammatory properties of jejunum.The results showed dietary supplementation improved integrity (Claudin-1, Occludin) inflammatory response...

Inflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells regulatory (Tregs) pivotal in pathogenesis progression IBD. This review summarizes role Th17/Treg equilibrium maintaining intestinal homeostasis, elucidating how its dysregulation contributes to development exacerbation It comprehensively synthesizes current understanding dietary...

Antibiotic related intestinal injury in early life affects subsequent health and susceptibility. Here, we employed weaned piglets as a model to investigate the protective effects of baicalin against early-life antibiotic exposure-induced microbial dysbiosis. Piglets exposed lincomycin showed marked reduction body weight (p < 0.05) deterioration jejunum morphology, alongside an increase antibiotic-resistant bacteria such Staphylococcus, Dolosicoccus, Escherichia-Shigella, Raoultella. In...

Oxidative stress, one of the most common biological dysfunctions, is usually associated with pathological conditions and multiple diseases in humans animals. Chinese olive fruit ( Canarium album L.) extracts (OE) are natural plant rich polyphenols (such as hydroxytyrosol, HT) antioxidant, anti-hyperlipidemia, anti-inflammatory potentials. This study was conducted to investigate antioxidant capacity OE supplementation its related molecular mechanism mice. Mice (25.46 ± 1.65 g) were treated...

Dysregulated lipid metabolism is a key pathology in metabolic diseases and the liver critical organ for metabolism. The gut microbiota has been shown to regulate hepatic host. However, underlying mechanism by which influences not elucidated. Here, depletion mouse model was constructed with an antibiotics cocktail (Abx) study through intestinal regulates high-fat diet (HFD)-fed mice. Our results showed that Abx treatment effectively eradicated these Microbiota reduced body weight fat...

The purpose of this study was to investigate the effects chemically protected sodium butyrate (CSB) on growth performance and early development function small intestine in broilers as one potential substitute for antibiotics. A total 192 one-day-old Arbor Acres male were randomly assigned into three dietary treatment groups (eight replicates per treatment): control (CON) diet; ANT diet, CON diet supplemented with antibiotics (enramycin, 8 mg/kg aureomycin, 100 mg/kg); CSB 1000 CSB,...

Oxidative stress is a major pathogenic factor in many intestinal diseases, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Nrf2 signaling pathway mitophagy can reduce reactive oxygen species (ROS) alleviate oxidative stress, but their relationship unclear. Hydroxytyrosol (HT), polyphenolic compound abundant olive oil, has strong antioxidant activity may help treat these diseases. We used pigs model to investigate HT's effect on damage its mechanisms. Diquat (DQ)...

Tibetan pigs were thought to have good performances of rough feeding tolerance, which may be related the gut microbiota. This study was conducted investigate changes colonic microbiota contribute fiber utilization in fed alfalfa supplementation diet compared with basal diet, and verified whether microbial community beneficial utilize using vitro fermentation. A total 40 allocated into two groups a corn-soybean meal (CD) or 50% (AD) for 42d. Our results showed CD improved carcass weight AD (p...