A5020321600- Gut microbiota and health
- Animal Nutrition and Physiology
- Effects of Environmental Stressors on Livestock
- Digestive system and related health
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Sulfur Compounds in Biology
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Single-cell and spatial transcriptomics
- Moringa oleifera research and applications
- Air Quality and Health Impacts
- Rabbits: Nutrition, Reproduction, Health
- Genomics, phytochemicals, and oxidative stress
- Antimicrobial Peptides and Activities
- Livestock and Poultry Management
- Ginger and Zingiberaceae research
- Plant Stress Responses and Tolerance
- Plant responses to water stress
Chinese Academy of Agricultural Sciences
2013-2024
Institute of Animal Sciences
2019-2024
The purpose of the current study was to investigate effect dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ (3 g kg-1) throughout study, starting 14 days prior DSS treatment for 1 week followed by 2 without DSS. results showed that restored DSS-induced disease activity index (DAI), colon length and histopathology scores tissue. Additionally, with reduced pro-inflammatory cytokine levels, enhanced level IL-10 serum....
This study aimed to evaluate the individual and combined effects of chemically protected sodium butyrate (CSB) xylo-oligosaccharide (XOS) on performance, anti-inflammatory antioxidant capacity, intestinal morphology microbiota broilers. A total 280 one-day-old Arbor Acres broilers were randomly distributed into 5 treatments: basal diet (CON), supplemented with 100 mg/kg aureomycin 8 enramycin (ABX), 1000 CSB (CSB), XOS (XOS), mixture (MIX), respectively. On d 21, ABX, CSB, MIX decreased feed...
Pectin is a heteropolysaccharide that acts as an intestinal immunomodulator, promoting development and regulating flora in the gut. However, relevant mechanisms remain obscure. In this study, pigs were fed corn-soybean meal-based diet supplemented with either 5% microcrystalline cellulose (MCC) or pectin for 3 weeks, to investigate metabolites anti-inflammatory properties of jejunum.The results showed dietary supplementation improved integrity (Claudin-1, Occludin) inflammatory response...
Inflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells regulatory (Tregs) pivotal in pathogenesis progression IBD. This review summarizes role Th17/Treg equilibrium maintaining intestinal homeostasis, elucidating how its dysregulation contributes to development exacerbation It comprehensively synthesizes current understanding dietary...
Antibiotic related intestinal injury in early life affects subsequent health and susceptibility. Here, we employed weaned piglets as a model to investigate the protective effects of baicalin against early-life antibiotic exposure-induced microbial dysbiosis. Piglets exposed lincomycin showed marked reduction body weight (p < 0.05) deterioration jejunum morphology, alongside an increase antibiotic-resistant bacteria such Staphylococcus, Dolosicoccus, Escherichia-Shigella, Raoultella. In...
Inulin (INU) is a non-digestible carbohydrate, known for its beneficial properties in metabolic disorders. However, whether and how gut microbiota regulation contributes to host metabolism has yet be investigated. We conduct this study examine the possible associations between circulating microbiota–host co-metabolites induced by inulin interventions. Plasma intestinal site samples were collected from pigs that have consumed diet 60 days. High-throughput sequencing was adopted microbial...
Oxidative stress is a major pathogenic factor in many intestinal diseases, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Nrf2 signaling pathway mitophagy can reduce reactive oxygen species (ROS) alleviate oxidative stress, but their relationship unclear. Hydroxytyrosol (HT), polyphenolic compound abundant olive oil, has strong antioxidant activity may help treat these diseases. We used pigs model to investigate HT's effect on damage its mechanisms. Diquat (DQ)...
This study aimed to investigate whether dietary bile acid (BA) supplements can improve growth performance and lipid metabolism in heat-stressed broiler chickens. A total of 288 Arbor Acres broilers were blocked by BW then randomly allocated into 4 treatments at 21 days age. Birds reared under 32 °C had a higher cloacal temperature (p = 0.01), faster respiratory rate < 0.001), greatly reduced average daily feed intake (ADFI, p 0.016), gain (ADG, 0.006), final body weight (FBW, 0.008),...
Bile acids are critical for lipid absorption, however, their new roles in maintaining or regulating systemic metabolism irreplaceable. The negative impacts of heat stress (HS) on growth performance, metabolism, and antioxidant status have been reported, but it remains unknown whether the bile (BA) composition broiler chickens can be affected by HS. Therefore, this study aimed to investigate modulating effects environment dietary BA supplementation benefit heat-stressed chickens. A total 216...
Ammonia, an atmospheric pollutant in the air, jeopardizes immune function, and perturbs metabolism, especially lipid human animals. The roles of intestinal microbiota its metabolites maintaining or regulating function metabolism are irreplaceable. Therefore, this study aimed to investigate how aerial ammonia exposure influences hindgut a pig model. Twelve growing pigs were treated with without (35 mg/m 3 ) for 25 days, then microbial diversity microbiota-derived measured. results...
Although high temperatures influence gut health, data on underlying mechanisms remains scant. Using a pig model, this study performed global analysis how chronic heat stress affects the transport and immune function of through transcriptome, proteome, microbial diversity flow cytometry. A total 27 pigs with similar body weights were assigned into 3 groups, control (Con) group (23 °C), stressed (HS) (33 pair-fed (PF) group, in controlled environment for 21 days. Our results showed that HS had...
The use of prebiotics to regulate gut microbiota is a promising strategy improve health. Pectin (PEC) prebiotic carbohydrate that enhances the health by promoting growth beneficial microbes. These microbes produce metabolites are known mucosal immune responses. This study was conducted better understand effects PEC on microbiome and immunity in pigs. Pigs were fed two diets, with or without 5% apple PEC, for 72 days. Effects microbiota, cytokine expression, short-chain fatty acids (SCFAs)...
According to the Chinese encyclopedia “ Ben Cao Gang Mu ” (AD 1552–1578), Caprifoliaceae and Scutellaria baicalensis Georgi are used in traditional medicine clear heat, detoxify, treat wind-heat colds, upper respiratory tract infections, pneumonia. However, mechanism effects of compound extracts on intestinal health remain unclear. From perspective microbes, this study assessed antioxidant, anti-inflammatory, protective properties Georgi. Mice received diets with or without extractive (BCA)...
The adverse effects of short-term megadose antibiotics exposure on the gastrointestinal and liver tissue reactions in young children have been reported. Antibiotic-induced intestinal are usually unpredictable present a poorly understood pathogenesis. It is, therefore, necessary to develop strategies for reducing antibiotics. Studies harm rescue measures from perspective gut-liver system lacking. Here, we demonstrate that lincomycin reduced body weight, disrupted composition gut microbiota...
The neonatal period is a crucial time during development of the mammalian small intestine. Moreover, and maturation intestine are exceptionally important for early growth, successful weaning, postweaning growth development, in order to achieve species-specific milestones. Although several publications recently characterized intestinal epithelial cell diversity at single-cell level, it remains unclear how differentiation molecular interactions take place between types subtypes cells period. A...
Ammonia, an aerial pollutant in animal facilities, affects health. Recent studies showed that ammonia negatively impacts meat quality but the mechanism remains unknown. To understand how drives its adverse effects on pig quality, 18 crossbred gilts were exposed to 0, 10 or 25 mg/m3 for days. Ammonia exposure increased fat content Longissimus dorsi muscle, and color got lighter after exposure. Analysis of MyHC isoforms IIx decreased I Besides, muscular glutamine significantly as increased....