A5068801234- Gut microbiota and health
- Diet and metabolism studies
- Carbon and Quantum Dots Applications
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Molecular Sensors and Ion Detection
- Nanocluster Synthesis and Applications
- Dietary Effects on Health
- Advanced Nanomaterials in Catalysis
- Cardiac Ischemia and Reperfusion
- Epigenetics and DNA Methylation
- Nitric Oxide and Endothelin Effects
- Luminescence and Fluorescent Materials
- Digestive system and related health
- Sperm and Testicular Function
- Advanced biosensing and bioanalysis techniques
- Phytoestrogen effects and research
- Amino Acid Enzymes and Metabolism
- Advanced MRI Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Circadian rhythm and melatonin
- Plant Stress Responses and Tolerance
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
Chinese Academy of Agricultural Sciences
2020-2025
University of Liège
2021-2025
Gembloux Agro-Bio Tech
2021-2025
Institute of Animal Sciences
2021-2025
Shanxi University
2018-2024
Shanxi University of Traditional Chinese Medicine
2018-2024
Hunan Agricultural University
2019-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Wenzhou Medical University
2024
Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals humans; however, it remains know whether melatonin prevents obesity through microbiota. Here, we found that high-fat diet promoted the accumulation intestinal dysbiosis mice, while oral supplementation alleviated reversed dysbiosis, including diversity of microbiota, relative abundances Bacteroides Alistipes, functional profiling microbial communities, such as energy metabolism, carbohydrate...
The construction of ratiometric fluorescence assay has displayed fantastic advantages in improving semi-quantitative visualization capability by presenting successive color changes. Herein, long-wavelength emission nitrogen-doped carbon dots (N-CDs) were developed for intrinsic detection silver ions (Ag+) and glutathione (GSH), accompanied variation orange green. label-free N-CDs favorably obtained through one-step hydrothermal synthesis single at 618 nm under the excitation wavelength 478...
The purpose of the current study was to investigate effect dietary dihydroquercetin (DHQ) supplementation on dextran sodium sulfate (DSS)-induced colitis in mice. Mice were given DHQ (3 g kg-1) throughout study, starting 14 days prior DSS treatment for 1 week followed by 2 without DSS. results showed that restored DSS-induced disease activity index (DAI), colon length and histopathology scores tissue. Additionally, with reduced pro-inflammatory cytokine levels, enhanced level IL-10 serum....
The goal of this study was to interrogate the role inducible NO synthase (iNOS) in late phase ischemic preconditioning (PC) vivo . A total 321 mice were used. Wild-type preconditioned 24 h earlier with six cycles 4-min coronary occlusion/4-min reperfusion exhibited a significant ( P < 0.05) increase myocardial iNOS protein content, activity (assessed as calcium-independent l -citrulline formation), and nitrite + nitrate tissue levels. In contrast, endothelial NOS content calcium-dependent...
Abstract —Although it is recognized that late preconditioning (PC) results from upregulation of cardioprotective genes, the specific transcription factor(s) govern this genetic adaptation remains unknown. The aim study was to test hypothesis development PC mediated by nuclear factor-κB (NF-κB) and elucidate mechanisms control activation NF-κB after an ischemic stimulus in vivo. A total 152 chronically instrumented, conscious rabbits were used. sequence six 4-minute coronary...
The goal of this study was to determine the role Janus tyrosine kinase (JAK)–signal transducers and activators transcription (STAT) pathway in late phase ischemic preconditioning (PC). A total 230 mice were used. At 5 min after PC (induced with six cycles 4-min coronary occlusion/4-min reperfusion), immunoprecipitation anti-phosphotyrosine (anti-pTyr) antibodies followed by immunoblotting anti-JAK revealed increased phosphorylation JAK1 (+257 ± 53%) JAK2 (+238 35%), indicating rapid...
Activating room-temperature phosphorescence (RTP) emission in aqueous environments is a challenging feat because of the releasing nonradiative decay pathways. Here, design strategy was presented that effectively promotes presence RTP carbon dots (CDs) solutions by utilizing CDs and melamine to construct hydrogen-bonded networks form polymer (M-CDs). The obtained M-CDs not only enjoy an ultralong lifetime 664 ms, but also relatively high quantum yield 25% environment at 468 nm excitation....
Our previous reports suggested that dietary supplementation with lysine influenced intestinal absorption and metabolism of amino acids. In this study, we further investigated the effect restriction (30%) on feed intake also tested hypothesis gut microbiome contributed to potential mechanism restriction-mediated feeding behavior. Here, profiled microbial communities by sequencing 16S ribosomal ribonucleic acid (rRNA) genes from samples as well growth performance, serum hormones, transport in...
The gut microbiota is strongly shaped by a high-fat diet, and obese humans animals are characterized low microbial diversity impaired compositions. Comprehensive data on mammalian metagenomes shows exhibit circadian rhythms, which disturbed diet. On the other hand, melatonin natural ubiquitous molecule showing multiple mechanisms of regulating clock lipid metabolism, while role in regulation diurnal patterns structure function not yet known. This study delineates an intricate picture...
A schematic illustration for assaying Cr(<sc>vi</sc>) and Cys activity by CDs with both fluorescent colorimetric readouts.
Novel orange-emitting N-doped carbon dots (N-CDs) were prepared as fluorescent and colorimetric dual-mode probes for sensing nitrite (NO2-). The obtained N-CDs possessed fantastic optical properties specific responses to NO2-. NO2- could induce the fluorescence static quenching of N-CDs, a linear relationship was in range from 2 60 μM with detection limit 0.35 μM. More interestingly, exhibited ratiometric absorption signals visible color conversion (red-purple), which allowed development...
Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” Chinese) Scutellaria baicalensis (“Huangqin” are two traditional Chinese medicinal plants rich polyphenols, such as chlorogenic acid (CGA) baicalin (BA), with effects of anti-inflammation antioxidation. However, it remains unknown whether extracts from L. S. (LSEs) could mitigate colonic inflammation. In present study, ICR mice (22.23 ± 1.65 g)...
Cyclooxygenase-2 (COX-2) is known to mediate the cardioprotective effects of late phase ischemic preconditioning (PC); however, signaling pathways involved in COX-2 induction following PC are unknown. In addition, although inducible nitric oxide synthase (iNOS) has been identified as a co-mediator together with COX-2, interaction between iNOS and heart Using conscious rabbits, we found that expression 24 hours after was blocked by pretreatment inhibitors protein kinase C (PKC), Src tyrosine...
In conscious rabbits, a sequence of six 4-min coronary occlusion/4-min reperfusion cycles, which elicits late preconditioning (PC), caused rapid activation calcium-dependent nitric oxide (NO) synthase (NOS) [cNOS; endothelial NOS (eNOS) and/or neuronal (nNOS)], whereas calcium-independent [inducible (iNOS)] activity remained unchanged. The enhanced cNOS was associated with increased myocardial levels NO 2 3 (NO x ). Twenty-four hours after ischemic PC induced, the opposite pattern observed,...
This study aimed to investigate the long-term effects of protein restriction from piglets finishing pigs for 16 weeks on meat quality, muscle amino acids, and acid transporters. Thirty-nine were randomly divided into three groups: a control (20-18-16% crude protein, CP) two restricted groups (17-15-13% CP 14-12-10% CP). The results showed that severe (14-12-10% inhibited feed intake body weight, while moderate had little effect growth performance in pigs. Meat quality (i.e., pH, color...
Lysine is a common limiting amino acid in human and animal diets plays an important role cell proliferation metabolism.
Obesity increases the risk of developing insulin resistance and diabetes is a major public health concern. Our previous study shows that dietary β-hydroxy-β-methylbutyrate (HMB) improves lipid metabolism in pig model. However, it remains unclear whether HMB blocks obesity through gut microbiota. In this study, we found reduced body weight, alleviated whitening brown adipose tissue, improved mice fed high-fat diet (HFD). High-throughput pyrosequencing 16S rRNA demonstrated administration...
Dysregulated lipid metabolism is a key pathology in metabolic diseases and the liver critical organ for metabolism. The gut microbiota has been shown to regulate hepatic host. However, underlying mechanism by which influences not elucidated. Here, depletion mouse model was constructed with an antibiotics cocktail (Abx) study through intestinal regulates high-fat diet (HFD)-fed mice. Our results showed that Abx treatment effectively eradicated these Microbiota reduced body weight fat...