A5103285060- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Gastrointestinal motility and disorders
- Lung Cancer Research Studies
- Phytochemical Studies and Bioactivities
- Pharmacological Effects of Natural Compounds
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Gut microbiota and health
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Exercise and Physiological Responses
- Reproductive Biology and Fertility
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
- Antibiotics Pharmacokinetics and Efficacy
Hunan Cancer Hospital
2025
Central South University
2025
National Cancer Center
2022-2024
CHA Bundang Medical Center
2024
CHA University
2024
Pusan National University
2017-2023
National Cancer Center
2022-2023
Korea Disease Control and Prevention Agency
2022-2023
Northeast Agricultural University
2023
Yantaishan Hospital
2020-2023
Context: Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, prevention histamine release and modulation CaCC chloride channel.Objective: We investigated laxative effect action mechanism QCT in Lop-induced constipation model.Materials methods: Constipation SD rats was induced by subcutaneous injection loperamide (Lop) (4 mg/kg weight) 0.5% Tween 20 twice day three days. After 24 h, group...
Obesity increases the risk of developing insulin resistance and diabetes is a major public health concern. Our previous study shows that dietary β-hydroxy-β-methylbutyrate (HMB) improves lipid metabolism in pig model. However, it remains unclear whether HMB blocks obesity through gut microbiota. In this study, we found reduced body weight, alleviated whitening brown adipose tissue, improved mice fed high-fat diet (HFD). High-throughput pyrosequencing 16S rRNA demonstrated administration...
This study aims to compare the meat quality of Shaziling and Yorkshire pigs find potential indicator in serum for superior quality. Six at 30, 60, 90, 150, 210, 300 d age were selected examine carcass traits, quality, metabolome. The results showed that body weight, length, loin eye area significantly lower than those (P < 0.05). 150 had backfat thickness Compared with pigs, all 6 ages a lean percentage higher fat At age, post-mortem pH-decline, b∗ value (yellowness), drip loss Moreover, a∗...
The therapeutic effects of mulberry (Morus alba) leaves on lipid metabolism, including lipogenesis, lipolysis and hyperlipidemia are widely known, although their fermented products yet to be applied. To investigate the a novel extract with Cordyceps militaris (EMfC) profile serum, accumulation, lipolytic activity lipogenesis regulation were measured in high fat diet (HFD)‑induced obese C57BL/6 mice treated EMfC for 12 weeks. Briefly, concentrations low‑density lipoprotein, triglyceride,...
The objective of the study is to evaluate and compare effects betaine or glycine on carcass trait, meat quality lipid metabolism finishing Huan Jiang mini-pigs. Betaine called trimethylglycine a methyl derivative glycine, but few researches were conducted impact dietary pigs. One hundred forty-four mini-pigs (body weight = 10.55 ± 0.15 kg; 70 d) randomly divided 3 treatment groups (basal diet, betaine). Results indicated that increased average daily gain (ADG) final (P < 0.05). Dietary...
A pharmacogenomic platform using patient-derived cells (PDCs) was established to identify the underlying resistance mechanisms and tailored treatment for patients with advanced or refractory lung cancer.Drug sensitivity screening multi-omics datasets were acquired from cancer PDCs (n = 102). Integrative analysis performed explore drug candidates according genetic variants, gene expression, clinical profiles.PDCs had genomic characteristics resembled those of solid tissues. PDC molecular...
The aims were to examine whether oral sodium propionate supplementation regulate lipid metabolism through modulating gut microbiota.ICR male mice (26·98 ± 0·30 g) randomly assigned three groups (n = 10) and fed control diet (Con), high-fat (HFD) HFD plus (Pro) respectively. In this study, we found that increased the weight of final body, inguinal white adipose tissues (iWAT), epididymal tissue (eWAT) perirenal (pWAT), as well adipocyte mean area iWAT eWAT in (P < 0·05), whereas treatment...
Here, we investigated the roles and mechanisms of flavonoids from mulberry leaves (FML) on lipid metabolism in high fat diet (HFD)-fed mice. ICR mice were fed either a control (Con) or HFD with without FML (240 mg/kg/day) by oral gavage for six weeks. administration improved accumulation, alleviated liver steatosis whitening brown adipose tissue, gut microbiota composition HFD-fed Microbiota transplantation FML-treated HFD-induced metabolic disorders. Moreover, restored production acetic...
Aims Leucine supplementation promotes intestinal health, but the mechanism is largely unknown. This study aimed to elucidate mechanisms underlying beneficial effects of leucine on homeostasis. Methods and Results Female ICR mice (6-week-old) were randomly assigned into three groups: (i) received a basal diet; (ii) dietary 0·5% crystalline l-leucine supplementation; (iii) 1·0% supplementation. Our results showed that stimulated secretion SIgA in ileum expression cytokines related production....
Hepatitis B virus (HBV) is a top contributor to hepatoma. Circular RNAs (circRNAs) have been elucidated close connection with HBV-induced This study aimed explore the role of circRNA BTB domain and CNC homolog 1 (circBACH1) in HBV replication hepatoma progression, as well potential mechanistic pathway.Quantitative real-time polymerase chain reaction (qRT-PCR) assay was performed assess expression circBACH1, microRNA (miR)-200a-3p, mitogen-activated protein kinase 2 (MAP3K2). determined by...
Abstract Isoniazid and ethambutol are commonly used in various combination treatments for tuberculosis, this reason a rapid sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed validated simultaneous quantification of these two drugs human plasma. After simple protein precipitation using methanol, the analytes internal standard metformin were chromatographed on C 18 column detected by MS/MS. An atmospheric pressure chemical ionization interface chosen to...
Positive physiological benefits of several plant oils on the UV-induced photoaging have been reported in some cell lines and model mice, but perilla oil collected from seeds Perilla frutescens L. has not investigated this context. To study therapeutic effects cold-pressed (CPO) vitro vivo, cellular damage cutaneous were assessed normal human dermal fibroblasts (NHDFs) HR-1 hairless mice. CPO contained five major fatty acids including linolenic acid (64.11%), oleic (16.34%), linoleic...
Mesenchymal stem cells-derived exosomes (MSC-Exo) are considered to have great potential in the treatment of human diseases. However, role MSC-Exo process diabetes with sepsis and underlying molecular mechanism remain unclear. Human pulmonary microvascular endothelial cells (HPMECs) were treated high glucose (HG) lipopolysaccharide (LPS). Cell viability, migration, angiogenesis analyzed by cell counting kit 8 assay, transwell assay tube formation assay. Transmembrane electrical resistance...
Background Although constipation has been researched in various neurological disorders, including Parkinson's disease (PD) and spinal cord injury (SCI), the pathological mechanism of this symptom not investigated Alzheimer's (AD) associated with loss nerve cells brain. This study was undertaken to gain scientific evidences for a molecular correlation between AD. Methods To understand etiology, we measured alterations parameters, muscarinic acetylcholine receptors (mAChRs) endoplasmic...
The aim of this study was to investigate the effects dietary β-hydroxy-β-methylbutyrate (HMB) on lipopolysaccharide (LPS)-induced muscle atrophy and mechanisms involved. Sixty pigs (21 ± 2 days old, 5.86 0.18 kg body weight) were used in a × 3 factorial design main factors included diet (0, 0.60%, or 1.20% HMB) immunological challenge (LPS saline). After 15 d treatment with LPS and/or HMB, growth performance, blood parameters, protein degradation rate measured. results showed that...
This study aimed to explore the effects of beta-hydroxy-beta-methyl butyrate (HMB) on serum metabolic profiles and meat quality muscles in Wenshi broiler chickens. Birds were fed a basal diet with an additional 0, 0.05, 0.10, or 0.15% HMB, respectively. Results showed that dietary HMB quadratically increased average daily gain ( P = 0.058) decreased feed:gain &lt; 0.05) mainly starter phase. At 51 days age, birds receiving 0.10% exhibited less abdominal fat more breast yield than control...
Although molecular subtypes of small-cell lung cancer (SCLC) have been proposed, their clinical relevance and therapeutic implications are not fully understood. Thus, we aimed to refine uncover targets. We classified the based on gene expression (n = 81) validated them in our samples 87). Non-SCLC were compared with SCLC identify early development stage SCLC. Single-cell transcriptome analysis was applied dissect TME bulk samples. Finally, overcome platinum resistance, performed drug...
Roots of Asparagus cochinchinesis have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain although the effects their fermented products not assessed until now. To investigate anti-inflammatory on macrophages a butanol extract from A. cochinchinensis roots with Weissella cibaria (BAW), alterations in inducible nitric oxide synthase (iNOS)-mediated cyclooxygenase-2 (COX-2) induction pathway cytokine expression were measured lipopolysaccharide...
Introduction: Roots of Asparagus cochinchinensis, which have pharmacologically active ingredients, received great attention because they show good therapeutic effects for various inflammatory diseases without specific toxicity. This study investigated the anti-asthmatic a butanol extract cochinchinensis roots that had been fermented with Weissella cibaria (BAW) and its possible underlying cholinergic regulation. Methods: Alterations markers molecular response factors were measured in an...