A5100784581- Cancer and Skin Lesions
- Hair Growth and Disorders
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Genetic and rare skin diseases.
- Dermatology and Skin Diseases
- Nonmelanoma Skin Cancer Studies
- Dermatologic Treatments and Research
- Carbohydrate Chemistry and Synthesis
- Fungal Infections and Studies
- Tumors and Oncological Cases
- Psoriasis: Treatment and Pathogenesis
- Oral Health Pathology and Treatment
- melanin and skin pigmentation
- Bone fractures and treatments
- Advanced Biosensing Techniques and Applications
- Orthopaedic implants and arthroplasty
- Gold and Silver Nanoparticles Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Nanoparticle-Based Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Mast cells and histamine
- Cutaneous Melanoma Detection and Management
- Autoimmune and Inflammatory Disorders
Jeonbuk National University
2016-2025
Chonbuk National University Hospital
2015-2024
California State University, Fresno
2015-2024
Arizona State University
2012-2024
Mercy Fitzgerald Hospital
2024
King Abdullah University of Science and Technology
2024
Jeonju University
2013-2023
Hanyang University
2011-2023
Seoul National University Bundang Hospital
2014-2023
Hallym University
2022-2023
The principal challenge that the synthesis of oligosaccharides biological importance presents is development a general approach for stereoselective introduction glycosidic linkage. It shown here (1S)-phenyl-2-(phenylsulfanyl)ethyl moiety at C-2 glycosyl donor can perform neighboring group participation to give quasi-stable anomeric sulfonium ion. Due steric and electronic factors, ion formed as trans-decalin ring system. Displacement by hydroxyl leads formation α-glycosides. NMR experiments...
Individual microbial species are known to occupy distinct metabolic niches within multi-species communities. However, it has remained largely unclear whether specialization can similarly occur a clonal bacterial population. More specifically, is not clear what functions such could provide and how be coordinated dynamically. Here, we show that exponentially growing Bacillus subtilis cultures divide into interacting subpopulations, including one population produces acetate, another...
Up-to-date, accurate information on the disease burden of motor neuron (MND) is cornerstone for evidence-based resource allocation and healthcare planning. We aimed to estimate MND globally from 1990 2019, as part Global Burden Disease, Injuries Risk Factor (GBD) study. Amyotrophic lateral sclerosis, progressive muscular atrophy, primary pseudobulbar palsy, spinal atrophy hereditary spastic paraplegia- were included analysis MNDs. measured age-standardized incidence, prevalence, death,...
TMSOTf-promoted glycosylations of 2-azido-2-deoxy-glucosyl trichloroacetimidates provide excellent α-anomeric selectivities when performed at a relatively high reaction temperature in the presence PhSEt or thiophene. NMR and computation studies have shown that these proceed through an equatorial anomeric sulfonium ion, which upon displacement by sugar alcohol provides axial glycoside. Computational indicated steric factors determine selective formation β-anomeric ion.
The rapid rise in the incidence of type 1 diabetes (T1D) suggests involvement environmental factors including viral infections. We evaluated association between infections and T1D by profiling antiviral antibodies using a high-throughput immunoproteomics approach patients with new-onset T1D. constructed protein array comprising complete proteomes seven viruses associated open reading frames from other common viruses. Antibody responses to 646 antigens were assessed 42 age- sex-matched...
This cohort study examines the incidence, prevalence, and risk of alopecia areata after COVID-19.
Background Imidazole propionate (IMP) is a histidine metabolite produced by some gut microorganisms in the human colon. Increased levels of IMP are associated with intestinal inflammation and development progression cardiovascular disease diabetes. However, anti-inflammatory activity has not been investigated. This study aimed to elucidate role treating atopic dermatitis (AD). Methods To understand how mediates immunosuppression AD, was intraperitoneally injected into Dermatophagoides...
The purpose of this study was to compare the results between exchange nailing (EN) and augmentation plating (AP) with a nail left in situ for nonisthmal femoral shaft nonunion after nailing.: Retrospective data analysis, November 1996-March 2006.A level I trauma center.Eighteen patients 18 nonunions.Seven 7 fractures treated nonunions EN 11 AP combined bone grafting.Union complications.Five group failed achieve union (72% failure rate), whereas all pseudarthroses obtained osseous union....
Francisella tularensis, which is a Gram negative bacterium that causes tularemia, has been classified by the Center for Disease Control and Prevention (CDC) as category A bioweapon. The development of vaccines, immunotherapeutics, diagnostics F. tularensis requires detailed knowledge saccharide structures can be recognized protective antibodies. We have synthesized inner core region lipopolysaccharide (LPS) to probe antigenic responses elicited live subunit vaccine. successful preparation...
SeroNet institutions have developed or implemented 61 diverse COVID-19 serological assays and are collaboratively working to harmonize these using reference materials establish standardized reporting units. This will facilitate clinical interpretation of serology results cross-comparison research data.
Activation of a glycosyl donor protected with 2-O-(S)-(phenylthiomethyl)benzyl ether chiral auxiliary results in the formation an anomeric β-sulfonium ion, which can be displaced sugar alcohols to give corresponding α-glycosides. Sufficient deactivation such donors by electron-withdrawing protecting groups is, however, critical avoid glycosylation oxacarbenium ion intermediate. The latter type pathway also suppressed installing additional substituents auxiliary.
Background: Although nail exchange with a larger diameter after additional reaming is typically considered the gold standard for failed femoral nailing, some reports question role of nailing. The purpose this study was to evaluate risk factors affecting outcome nailing shaft nonunion initial Methods: Forty-one consecutive patients treated between November 1996 and March 2010 that initially managed an intramedullary were retrospectively reviewed. Possible (bony union) evaluated. Results: Of...
AMPylation (adenylylation) is a recently discovered mechanism employed by infectious bacteria to regulate host cell signaling. However, despite significant effort, only few targets have been identified, limiting our understanding of how these pathogens exploit this control cells. Accordingly, we developed novel nonradioactive screening platform using high-density cell-free protein microarrays displaying human proteins produced translational machinery. We screened 10,000 unique with Vibrio...
In the treatment of keloids, recurrence after surgical excision is relatively high. Various types adjuvant therapy such as radiotherapy and corticosteroid injection have been used to reduce recurrence.The aim this study was determine appropriate time for initiating postoperative analyze factors associated with occurrence keloids.Of these 37 lesions, 22 were located in ear lobe, 6 helix auricle, 4 on shoulder, 3 chest wall, 2 abdomen. Causative piercings (n=24), trauma (n=5), previous lesions...
Better and more diverse biomarkers for the development of simple point-of-care tests active tuberculosis (TB), a clinically heterogeneous disease, are urgently needed. We generated proteomic Mycobacterium (Mtb) High-Density Nucleic Acid Programmable Protein Array (HD-NAPPA) that used novel multiplexed strategy expedited high-throughput screening antibody responses to Mtb proteome. screened sera from HIV uninfected coinfected TB patients controls (n = 120) US South Africa (SA) using multiplex...