A5052122028- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Inflammation biomarkers and pathways
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- FOXO transcription factor regulation
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Multiple Myeloma Research and Treatments
- interferon and immune responses
- Neonatal Respiratory Health Research
- Chronic Lymphocytic Leukemia Research
Hunan Cancer Hospital
2022-2025
Central South University
2022-2025
Abstract Immune evasion contributes to cancer growth and progression. Cancer cells have the ability activate different immune checkpoint pathways that harbor immunosuppressive functions. The programmed death protein 1 (PD-1) cell ligands (PD-Ls) are considered be major molecules. interaction of PD-1 PD-L1 negatively regulates adaptive response mainly by inhibiting activity effector T while enhancing function regulatory (Tregs), largely contributing maintenance homeostasis prevents...
Cisplatin (DDP)-based chemoradiotherapy is one of the standard treatments for nasopharyngeal carcinoma (NPC). However, sensitivity and side effects DDP to patients remain major obstacles NPC treatment. This research aimed study regulated by cancer-associated fibroblasts (CAFs) through modulating ferroptosis. We demonstrated that triggered ferroptosis in cells, it inhibited tumor growth via inducing xenograft model. CAFs secreted high level FGF5, thus inhibiting DDP-induced cells....
Acute myeloid leukemia (AML) is a major with high mortality. Ferroptosis an important regulator of cancers. However, the role ferroptosis and its regulatory mechanisms in AML remain largely unknown. In this study, we reported elevated brain muscle ARNT-Like protein-1 (Bmal1) expression patients cell lines, upregulation indicated poor survival patients. The correlation analysis showed that Bmal1 was closely correlated cytogenetics French-American-British subtypes, but not age, gender white...
Abstract Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce anticancer immunity. However, the regulatory mechanisms macrophage polarization and its functional roles in nasopharyngeal carcinoma (NPC) progression need be further explored. Here we found that SPLUNC1 was highly expressed responsible for polarization. JAK/STATs pathway activation involved SPLUNC1-mediated Importantly, regulation affected CM-mediated influence on NPC cell proliferation migration....
Nasopharyngeal carcinoma (NPC) is the most common cancer originating in nasopharynx. Metabolic reprogramming plays a critical role tumor progression. Exploring mechanisms underlying metabolic contributes to deeper understanding of NPC pathogenesis. Here, we found downregulation RORA and SPLUNC1 NPC, indicates poor prognosis. binds promoter induce its transcription, overexpression inhibits cell proliferation glycolysis by directly upregulating SPLUNC1. UBR5 via promoting ubiquitination...
Venetoclax is a BCL2-targeted drug employed in treating various cancers, particularly hematologic malignancies. combination therapies are increasingly recognized as promising treatment strategies for acute myeloid leukemia (AML). In this study, we conducted an unbiased screen and identified anlotinib, multi-targeted receptor tyrosine kinase inhibitor with oral activity currently utilized the of solid tumor, potent enhancer venetoclax's anticancer AML. Our investigation encompassed AML cell...
Background Nasopharyngeal carcinoma (NPC) is a distinct subtype of head and neck cancer which prevalent in south China southeastern Asia. Consistent activation interferon (IFN) signaling, impairment T cell mediated antitumor immunity frequent NPC. Forkhead box A1 (FOXA1) one the earliest discovered pioneer factors, can open up compact chromatin structures to facilitate binding other proteins chromatin. Methods By using RNA sequencing, it was that FOXA1 suppresses signaling pathway expression...
The prognosis of children with refractory acute myeloid leukemia (AML) is poor. Complete remission (CR) not always achieved current salvage chemotherapy regimens before transplantation, and some patients have no chance transplantation. Here, we aimed to describe a new regimen conventional drugs (homoharringtonine, cladribine , aclarubicin (HCA)) for AML its mechanism in vitro. We retrospectively collected the clinical data 5 primary using HCA as reinduction chemotherapy, CR rates, adverse...
Abstract Background: Nasopharyngeal carcinoma (NPC) is one of the aggressive malignant tumors with high mortality, and proliferation myeloid-derived suppressor cells (MDSCs) could promote metastasis NPC through inhibiting function T cells. Meanwhile, SPLUNC1 was known to inhibit behavior cells, while detailed in LPS-modified immune microenvironment remains unclear. Methods: To assess impact during progression NPC, were exposed LPS then co-cultured MDSCs for 48 h. RT-qPCR western blot...